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Article: Diminished hepatic growth hormone receptor binding in sex-linked dwarf broiler and leghorn chickens (42473)

TitleDiminished hepatic growth hormone receptor binding in sex-linked dwarf broiler and leghorn chickens (42473)
Authors
Issue Date1987
PublisherSociety for Experimental Biology and Medicine. The Journal's web site is located at http://www.ebmonline.org/
Citation
Proceedings Of The Society For Experimental Biology And Medicine, 1987, v. 184 n. 2, p. 234-238 How to Cite?
AbstractHepatic growth hormone (GH) receptor binding was compared in normal and sex-linked dwarfs (SLD) from both Hubbard and Cornell strain chickens. At 6, 8, and 20 weeks of age, hepatic GH receptor binding in the Hubbard SLD chickens was significantly lower than that of normal fast-growing birds. At 20 weeks of age, only 2 of 22 SLD chickens in the Hubbard broiler strain showed positive binding at a high enough level to allow for Scatchard analysis. The affinity constants and binding capacities of these two SLD chickens were numerically (but not significantly) lower than those of the normal fast-growing birds. We further examined hepatic GH receptor binding in two closely related White Leghorn strains of chickens that have been maintained as closed breeding populations for many years. We observed no detectable hepatic GH binding in the Cornell SLD chickens (N=20), as compared to the normal-growing control strain (K strain). In both SLD strains, pretreatment with 4 M MgCl2 did not enhance GH binding, suggesting that there was no endogenous GH binding to the receptor. Based on these data, we suggest that the lack, or greatly reduced number, of GH receptors may be a major contributing factor to the dwarfism observed in these strains.
Persistent Identifierhttp://hdl.handle.net/10722/178456
ISSN
2002 Impact Factor: 2.714
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, FCen_US
dc.contributor.authorStyles, WJen_US
dc.contributor.authorRosenblum, CIen_US
dc.date.accessioned2012-12-19T09:47:47Z-
dc.date.available2012-12-19T09:47:47Z-
dc.date.issued1987en_US
dc.identifier.citationProceedings Of The Society For Experimental Biology And Medicine, 1987, v. 184 n. 2, p. 234-238en_US
dc.identifier.issn0037-9727en_US
dc.identifier.urihttp://hdl.handle.net/10722/178456-
dc.description.abstractHepatic growth hormone (GH) receptor binding was compared in normal and sex-linked dwarfs (SLD) from both Hubbard and Cornell strain chickens. At 6, 8, and 20 weeks of age, hepatic GH receptor binding in the Hubbard SLD chickens was significantly lower than that of normal fast-growing birds. At 20 weeks of age, only 2 of 22 SLD chickens in the Hubbard broiler strain showed positive binding at a high enough level to allow for Scatchard analysis. The affinity constants and binding capacities of these two SLD chickens were numerically (but not significantly) lower than those of the normal fast-growing birds. We further examined hepatic GH receptor binding in two closely related White Leghorn strains of chickens that have been maintained as closed breeding populations for many years. We observed no detectable hepatic GH binding in the Cornell SLD chickens (N=20), as compared to the normal-growing control strain (K strain). In both SLD strains, pretreatment with 4 M MgCl2 did not enhance GH binding, suggesting that there was no endogenous GH binding to the receptor. Based on these data, we suggest that the lack, or greatly reduced number, of GH receptors may be a major contributing factor to the dwarfism observed in these strains.en_US
dc.languageengen_US
dc.publisherSociety for Experimental Biology and Medicine. The Journal's web site is located at http://www.ebmonline.org/en_US
dc.relation.ispartofProceedings of the Society for Experimental Biology and Medicineen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChickensen_US
dc.subject.meshDwarfism - Genetics - Metabolism - Veterinaryen_US
dc.subject.meshLiver - Metabolismen_US
dc.subject.meshMagnesium - Pharmacologyen_US
dc.subject.meshMagnesium Chlorideen_US
dc.subject.meshPoultry Diseases - Genetics - Metabolismen_US
dc.subject.meshReceptors, Somatotropin - Drug Effects - Metabolismen_US
dc.subject.meshSex Factorsen_US
dc.subject.meshSpecies Specificityen_US
dc.titleDiminished hepatic growth hormone receptor binding in sex-linked dwarf broiler and leghorn chickens (42473)en_US
dc.typeArticleen_US
dc.identifier.emailLeung, FC: fcleung@hkucc.hku.hken_US
dc.identifier.authorityLeung, FC=rp00731en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3809176-
dc.identifier.scopuseid_2-s2.0-0023107133en_US
dc.identifier.volume184en_US
dc.identifier.issue2en_US
dc.identifier.spage234en_US
dc.identifier.epage238en_US
dc.identifier.isiWOS:A1987F949700018-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLeung, FC=7103078633en_US
dc.identifier.scopusauthoridStyles, WJ=6603625839en_US
dc.identifier.scopusauthoridRosenblum, CI=6701587112en_US

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