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Article: Purified chicken growth hormone (GH) and a human pancreatic GH-releasing hormone increase body weight gain in chickens

TitlePurified chicken growth hormone (GH) and a human pancreatic GH-releasing hormone increase body weight gain in chickens
Authors
Issue Date1986
PublisherThe Endocrine Society. The Journal's web site is located at http://endo.endojournals.org
Citation
Endocrinology, 1986, v. 118 n. 5, p. 1961-1965 How to Cite?
AbstractPurified chicken GH (cGH) and a synthetic human GH-releasing hormone (hpGRF) were tested for the ability to improve growth performance in chickens. Purified cGH was given to 4-week-old cockerels at 5, 10, and 50 μg/day for 14 days via daily iv injection. Body weights of chickens receiving 5 and 10 μg/day cGH were significantly increased at 6 days by 13.5% and 11.2%, respectively, relative to control values. At 14 days, body weights averaged 8.1% and 7.7% greater than controls, but these values were not statistically significant. There was a slight stimulation of body weight gain in chickens receiving 50 μg/day cGH. In general, cGH produces a transient stimulation of body weight gain in chickens. hpGRF was also given to 4-week-old cockerels for 14 days via daily iv injection at 0.1, 1.0, and 10.0 μg/day. hpGRF at 0.1 μg/bird daily increased body weight on day 14 (9.1% over the control value). The stimulating effects of hpGRF on body weight are also transient. The effects of cGH on serum somatomedin-C (SM-C) were examined. Serum SM-C concentrations were significantly elevated 24 and 36 h after injection of cGH. In conclusion, purified cGH and hpGRF appear to have some growth-promoting activity. The stimulatory effect of hpGRF on weight gain may be mediated via GH, and the stimulatory effect on cGH could be mediated through SM-C.
Persistent Identifierhttp://hdl.handle.net/10722/178448
ISSN
2015 Impact Factor: 4.159
2015 SCImago Journal Rankings: 2.363
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, FCen_US
dc.contributor.authorTaylor, JEen_US
dc.contributor.authorWien, Sen_US
dc.contributor.authorVan Iderstine, Aen_US
dc.date.accessioned2012-12-19T09:47:45Z-
dc.date.available2012-12-19T09:47:45Z-
dc.date.issued1986en_US
dc.identifier.citationEndocrinology, 1986, v. 118 n. 5, p. 1961-1965en_US
dc.identifier.issn0013-7227en_US
dc.identifier.urihttp://hdl.handle.net/10722/178448-
dc.description.abstractPurified chicken GH (cGH) and a synthetic human GH-releasing hormone (hpGRF) were tested for the ability to improve growth performance in chickens. Purified cGH was given to 4-week-old cockerels at 5, 10, and 50 μg/day for 14 days via daily iv injection. Body weights of chickens receiving 5 and 10 μg/day cGH were significantly increased at 6 days by 13.5% and 11.2%, respectively, relative to control values. At 14 days, body weights averaged 8.1% and 7.7% greater than controls, but these values were not statistically significant. There was a slight stimulation of body weight gain in chickens receiving 50 μg/day cGH. In general, cGH produces a transient stimulation of body weight gain in chickens. hpGRF was also given to 4-week-old cockerels for 14 days via daily iv injection at 0.1, 1.0, and 10.0 μg/day. hpGRF at 0.1 μg/bird daily increased body weight on day 14 (9.1% over the control value). The stimulating effects of hpGRF on body weight are also transient. The effects of cGH on serum somatomedin-C (SM-C) were examined. Serum SM-C concentrations were significantly elevated 24 and 36 h after injection of cGH. In conclusion, purified cGH and hpGRF appear to have some growth-promoting activity. The stimulatory effect of hpGRF on weight gain may be mediated via GH, and the stimulatory effect on cGH could be mediated through SM-C.en_US
dc.languageengen_US
dc.publisherThe Endocrine Society. The Journal's web site is located at http://endo.endojournals.orgen_US
dc.relation.ispartofEndocrinologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBody Weight - Drug Effectsen_US
dc.subject.meshChickens - Growth & Developmenten_US
dc.subject.meshGrowth Hormone - Metabolism - Pharmacologyen_US
dc.subject.meshGrowth Hormone-Releasing Hormone - Pharmacologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInsulin-Like Growth Factor I - Blooden_US
dc.subject.meshLiver - Drug Effects - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshPancreas - Analysisen_US
dc.titlePurified chicken growth hormone (GH) and a human pancreatic GH-releasing hormone increase body weight gain in chickensen_US
dc.typeArticleen_US
dc.identifier.emailLeung, FC: fcleung@hkucc.hku.hken_US
dc.identifier.authorityLeung, FC=rp00731en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1210/endo-118-5-1961-
dc.identifier.pmid3084211-
dc.identifier.scopuseid_2-s2.0-0022647670en_US
dc.identifier.volume118en_US
dc.identifier.issue5en_US
dc.identifier.spage1961en_US
dc.identifier.epage1965en_US
dc.identifier.isiWOS:A1986C003400032-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLeung, FC=7103078633en_US
dc.identifier.scopusauthoridTaylor, JE=7405405625en_US
dc.identifier.scopusauthoridWien, S=55317365000en_US
dc.identifier.scopusauthoridVan Iderstine, A=6602377005en_US

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