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Article: 5-Hydroxytryptamine: A modulator of food composition but not quantity?

Title5-Hydroxytryptamine: A modulator of food composition but not quantity?
Authors
Issue Date1984
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 1984, v. 34 n. 25, p. 2453-2460 How to Cite?
AbstractAfter a meal of protein, in contrast to a meal of carbohydrate (CHO) at 1915 hr, rats allowed to choose from high carbohydrate and high protein diets during 2000-2100 hr prefer CHO (1). Thus the hypothesis that this regulation of macronutrient selection involves brain 5-hydroxytryptamine (5-HT) metabolism was tested. Compared to three baseline days during which rats (250-300 g) consumed 1 g CHO, rats fed tryptophan (TRP, 5-HT precursor; 15 mg in 1 g CHO) selected meals higher in protein concentration (35.4% vs 46.6%, F (1,12)=20.05, p<0.001) from 10% and 60% casein diets during 2000-2100 hr. Associated with the higher protein selection was an elevated brain 5-HT turnover in rats killed 30 minutes after consuming CHO + TRP. Pretreating rats with p-chlorophenylalanine, an inhibitor of TRP hydroxylase, blocked this effect of TRP (36.3% vs 37.0%). Fenfluramine (1 and 2 mg/kg i.p. at 1945 hr), which transiently enhances neuronal 5-HT release, increased the rat's relative preference for protein from 28.8% to 37.5% (2 mg/kg, t=3.21, p<0.025) during 200-2100 hr. These rats, also exhibited a selective preference for CHO between 3-12 hrs post injection which paralleled the known subsequent depletion of 5-HT by fenfluramine. We conclude that the relative proportion of protein and carbohydrate selected in a meal is controlled, at lest in part, by prior food effects on brain 5-HT metabolism.
Persistent Identifierhttp://hdl.handle.net/10722/178425
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, ETSen_US
dc.contributor.authorAnderson, GHen_US
dc.date.accessioned2012-12-19T09:47:38Z-
dc.date.available2012-12-19T09:47:38Z-
dc.date.issued1984en_US
dc.identifier.citationLife Sciences, 1984, v. 34 n. 25, p. 2453-2460en_US
dc.identifier.issn0024-3205en_US
dc.identifier.urihttp://hdl.handle.net/10722/178425-
dc.description.abstractAfter a meal of protein, in contrast to a meal of carbohydrate (CHO) at 1915 hr, rats allowed to choose from high carbohydrate and high protein diets during 2000-2100 hr prefer CHO (1). Thus the hypothesis that this regulation of macronutrient selection involves brain 5-hydroxytryptamine (5-HT) metabolism was tested. Compared to three baseline days during which rats (250-300 g) consumed 1 g CHO, rats fed tryptophan (TRP, 5-HT precursor; 15 mg in 1 g CHO) selected meals higher in protein concentration (35.4% vs 46.6%, F (1,12)=20.05, p<0.001) from 10% and 60% casein diets during 2000-2100 hr. Associated with the higher protein selection was an elevated brain 5-HT turnover in rats killed 30 minutes after consuming CHO + TRP. Pretreating rats with p-chlorophenylalanine, an inhibitor of TRP hydroxylase, blocked this effect of TRP (36.3% vs 37.0%). Fenfluramine (1 and 2 mg/kg i.p. at 1945 hr), which transiently enhances neuronal 5-HT release, increased the rat's relative preference for protein from 28.8% to 37.5% (2 mg/kg, t=3.21, p<0.025) during 200-2100 hr. These rats, also exhibited a selective preference for CHO between 3-12 hrs post injection which paralleled the known subsequent depletion of 5-HT by fenfluramine. We conclude that the relative proportion of protein and carbohydrate selected in a meal is controlled, at lest in part, by prior food effects on brain 5-HT metabolism.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_US
dc.relation.ispartofLife Sciencesen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrain Chemistry - Drug Effectsen_US
dc.subject.meshDietary Carbohydratesen_US
dc.subject.meshDietary Proteinsen_US
dc.subject.meshFenclonine - Pharmacologyen_US
dc.subject.meshFenfluramine - Pharmacologyen_US
dc.subject.meshFood Preferencesen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshSerotonin - Analysis - Physiologyen_US
dc.subject.meshTryptophan - Pharmacologyen_US
dc.title5-Hydroxytryptamine: A modulator of food composition but not quantity?en_US
dc.typeArticleen_US
dc.identifier.emailLi, ETS: etsli@hku.hken_US
dc.identifier.authorityLi, ETS=rp00737en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0024-3205(84)90281-9en_US
dc.identifier.pmid6233467-
dc.identifier.scopuseid_2-s2.0-0021274898en_US
dc.identifier.volume34en_US
dc.identifier.issue25en_US
dc.identifier.spage2453en_US
dc.identifier.epage2460en_US
dc.identifier.isiWOS:A1984ST14300003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLi, ETS=14018169600en_US
dc.identifier.scopusauthoridAnderson, GH=7404223441en_US

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