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Article: In vivo and in vitro stimulation of growth hormone release in chickens by synthetic human pancreatic growth hormone releasing factor (hpGRFs)

TitleIn vivo and in vitro stimulation of growth hormone release in chickens by synthetic human pancreatic growth hormone releasing factor (hpGRFs)
Authors
Issue Date1983
PublisherThe Endocrine Society. The Journal's web site is located at http://endo.endojournals.org
Citation
Endocrinology, 1983, v. 113 n. 5, p. 1913-1915 How to Cite?
AbstractThe effect of the synthetic human pancreatic GH releasing factors (hpGRFs, hpGRF44 and hpGRF40) on GH release was studied both in vivo and in vitro. Four-week-old cockerels were injected iv with hpGRFs at 0.1 μg, 1.0 μg, and 10.0 μg/bird. The 0.1 μg dose of hpGRFs had no effect on plasma GH levels, but the 1.0 μg and 10.0 μg doses of hpGRFs caused a dose-dependent elevation of plasma GH. Plasma GH levels returned to basal 60 min after injection. hpGRFs, thyrotropin releasing hormone (TRH) and somatostatin (SRIF) were examined in a chicken in vitro pituitary cell culture system. In vitro hpGRFs and TRH caused a significant dose-dependent release of chicken GH, and the ability to stimulate GH was additive when hpGRF44 and TRH were added together in the culture medium. SRIF showed no consistent effect on the release of chicken GH, but it inhibited the stimulatory effect of hpGRF44 on chicken GH release. We conclude that hpGRF is a potent releaser of chicken GH in vivo and in vitro.
Persistent Identifierhttp://hdl.handle.net/10722/178420
ISSN
2015 Impact Factor: 4.159
2015 SCImago Journal Rankings: 2.363
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, FCen_US
dc.contributor.authorTaylor, JEen_US
dc.date.accessioned2012-12-19T09:47:37Z-
dc.date.available2012-12-19T09:47:37Z-
dc.date.issued1983en_US
dc.identifier.citationEndocrinology, 1983, v. 113 n. 5, p. 1913-1915en_US
dc.identifier.issn0013-7227en_US
dc.identifier.urihttp://hdl.handle.net/10722/178420-
dc.description.abstractThe effect of the synthetic human pancreatic GH releasing factors (hpGRFs, hpGRF44 and hpGRF40) on GH release was studied both in vivo and in vitro. Four-week-old cockerels were injected iv with hpGRFs at 0.1 μg, 1.0 μg, and 10.0 μg/bird. The 0.1 μg dose of hpGRFs had no effect on plasma GH levels, but the 1.0 μg and 10.0 μg doses of hpGRFs caused a dose-dependent elevation of plasma GH. Plasma GH levels returned to basal 60 min after injection. hpGRFs, thyrotropin releasing hormone (TRH) and somatostatin (SRIF) were examined in a chicken in vitro pituitary cell culture system. In vitro hpGRFs and TRH caused a significant dose-dependent release of chicken GH, and the ability to stimulate GH was additive when hpGRF44 and TRH were added together in the culture medium. SRIF showed no consistent effect on the release of chicken GH, but it inhibited the stimulatory effect of hpGRF44 on chicken GH release. We conclude that hpGRF is a potent releaser of chicken GH in vivo and in vitro.en_US
dc.languageengen_US
dc.publisherThe Endocrine Society. The Journal's web site is located at http://endo.endojournals.orgen_US
dc.relation.ispartofEndocrinologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChickensen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshGrowth Hormone - Metabolismen_US
dc.subject.meshGrowth Hormone-Releasing Hormone - Pharmacologyen_US
dc.subject.meshPancreatic Neoplasms - Analysisen_US
dc.subject.meshPituitary Gland - Drug Effectsen_US
dc.subject.meshSomatostatin - Pharmacologyen_US
dc.subject.meshThyrotropin-Releasing Hormone - Pharmacologyen_US
dc.titleIn vivo and in vitro stimulation of growth hormone release in chickens by synthetic human pancreatic growth hormone releasing factor (hpGRFs)en_US
dc.typeArticleen_US
dc.identifier.emailLeung, FC: fcleung@hkucc.hku.hken_US
dc.identifier.authorityLeung, FC=rp00731en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1210/endo-113-5-1913-
dc.identifier.pmid6138249-
dc.identifier.scopuseid_2-s2.0-0020571127en_US
dc.identifier.volume113en_US
dc.identifier.issue5en_US
dc.identifier.spage1913en_US
dc.identifier.epage1915en_US
dc.identifier.isiWOS:A1983RN22300056-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLeung, FC=7103078633en_US
dc.identifier.scopusauthoridTaylor, JE=7405405625en_US

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