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Article: Effects of naproxen and methotrexate on the extent of aortic lesions and cholesterol concentrations in cholesterol-fed rabbits

TitleEffects of naproxen and methotrexate on the extent of aortic lesions and cholesterol concentrations in cholesterol-fed rabbits
Authors
Issue Date1980
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexmp
Citation
Experimental And Molecular Pathology, 1980, v. 33 n. 3, p. 349-352 How to Cite?
AbstractIn this study rabbits were fed a hypercholesterolemic diet for 8 weeks with and without drug additives. Extent of aortic lesions was determined by planimetry and cholesterol concentrations by chemical analysis. Results in the naproxen-treated group were not significantly different from those in the untreated group. Methotrexate, a DNA synthesis inhibitor, resulted in significantly less extensive lesions and in lower aortic cholesterol concentrations. We have previously shown that two other compounds, hydroxyurea and mercaptopurine, that interfere with DNA synthesis have a similar beneficial effect. Aortic tissue cholesterol and extent of lesions were shown in this study (and previously) to be significantly correlated. Since drugs frequently have multiple metabolic effects these drugs might produce their effects on the lesion by retarding cholesterol accumulation in the aorta. However, it seems more likely that the effect was produced by retardation of proliferation of smooth muscle cells (either by preventing entry into the DNA synthesis phase or by death in the peridivision phase). The lower cholesterol accumulation in the aorta could be secondary perhaps because fewer cells were present that were susceptible to excessive cholesterol accumulation.
Persistent Identifierhttp://hdl.handle.net/10722/178413
ISSN
2015 Impact Factor: 2.638
2015 SCImago Journal Rankings: 1.130
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, WMen_US
dc.contributor.authorLee, KTen_US
dc.contributor.authorReiner, JMen_US
dc.date.accessioned2012-12-19T09:47:35Z-
dc.date.available2012-12-19T09:47:35Z-
dc.date.issued1980en_US
dc.identifier.citationExperimental And Molecular Pathology, 1980, v. 33 n. 3, p. 349-352en_US
dc.identifier.issn0014-4800en_US
dc.identifier.urihttp://hdl.handle.net/10722/178413-
dc.description.abstractIn this study rabbits were fed a hypercholesterolemic diet for 8 weeks with and without drug additives. Extent of aortic lesions was determined by planimetry and cholesterol concentrations by chemical analysis. Results in the naproxen-treated group were not significantly different from those in the untreated group. Methotrexate, a DNA synthesis inhibitor, resulted in significantly less extensive lesions and in lower aortic cholesterol concentrations. We have previously shown that two other compounds, hydroxyurea and mercaptopurine, that interfere with DNA synthesis have a similar beneficial effect. Aortic tissue cholesterol and extent of lesions were shown in this study (and previously) to be significantly correlated. Since drugs frequently have multiple metabolic effects these drugs might produce their effects on the lesion by retarding cholesterol accumulation in the aorta. However, it seems more likely that the effect was produced by retardation of proliferation of smooth muscle cells (either by preventing entry into the DNA synthesis phase or by death in the peridivision phase). The lower cholesterol accumulation in the aorta could be secondary perhaps because fewer cells were present that were susceptible to excessive cholesterol accumulation.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexmpen_US
dc.relation.ispartofExperimental and Molecular Pathologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAorta - Pathologyen_US
dc.subject.meshArteriosclerosis - Prevention & Controlen_US
dc.subject.meshBody Weight - Drug Effectsen_US
dc.subject.meshCell Division - Drug Effectsen_US
dc.subject.meshCholesterol - Blooden_US
dc.subject.meshDiet, Atherogenicen_US
dc.subject.meshMaleen_US
dc.subject.meshMethotrexate - Pharmacologyen_US
dc.subject.meshNaproxen - Pharmacologyen_US
dc.subject.meshRabbitsen_US
dc.titleEffects of naproxen and methotrexate on the extent of aortic lesions and cholesterol concentrations in cholesterol-fed rabbitsen_US
dc.typeArticleen_US
dc.identifier.emailLee, WM: hrszlwm@hku.hken_US
dc.identifier.authorityLee, WM=rp00728en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0014-4800(80)90033-7-
dc.identifier.pmid7449930-
dc.identifier.scopuseid_2-s2.0-0019186679en_US
dc.identifier.volume33en_US
dc.identifier.issue3en_US
dc.identifier.spage349en_US
dc.identifier.epage352en_US
dc.identifier.isiWOS:A1980KW27900010-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLee, WM=24799156600en_US
dc.identifier.scopusauthoridLee, KT=8054054000en_US
dc.identifier.scopusauthoridReiner, JM=7102726225en_US

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