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Article: Advanced coronary atherosclerosis in swine produced by combination of balloon catheter injury and cholesterol feeding

TitleAdvanced coronary atherosclerosis in swine produced by combination of balloon catheter injury and cholesterol feeding
Authors
Issue Date1975
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexmp
Citation
Experimental And Molecular Pathology, 1975, v. 23 n. 3, p. 491-499 How to Cite?
AbstractThere has been a constant demand for an animal model of advanced coronary atherosclerosis produced in a short period. It was known that mild atherosclerosis could be produced in various vascular beds by high cholesterol diets. However, it requires considerable time to produce advanced atherosclerotic lesions by diets alone. The current study was designed to investigate effects of combination of a balloon denudation procedure and high cholesterol diet in swine. The authors could produce advanced atherosclerotic lesions in coronary arteries in cholesterol fed swine within a short period of time by inserting a balloon catheter via carotid artery into the coronary artery, inflating it so as to distend the lumen, and pulling it back quickly, which resulted in extensive denudation of the endothelium of coronary arteries. An atherosclerosis like lesion develops at the site with eventual narrowing of the lumen leading to myocardial ischemia, myocardial infarction, and occasionally sudden death, thus resembling in many aspects human coronary artery disease. Among 22 swine studied, 10 had severe atherosclerosis with virtual occlusion of proximal portion of either or both coronary arteries and developed myocardial infarction within 2-3 months. Seven of these died suddenly, probably due to arrhythmia. This model should be appropriate for studies where advanced coronary atherosclerosis with its complications is needed.
Persistent Identifierhttp://hdl.handle.net/10722/178398
ISSN
2015 Impact Factor: 2.638
2015 SCImago Journal Rankings: 1.130
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, WMen_US
dc.contributor.authorLee, KTen_US
dc.date.accessioned2012-12-19T09:47:28Z-
dc.date.available2012-12-19T09:47:28Z-
dc.date.issued1975en_US
dc.identifier.citationExperimental And Molecular Pathology, 1975, v. 23 n. 3, p. 491-499en_US
dc.identifier.issn0014-4800en_US
dc.identifier.urihttp://hdl.handle.net/10722/178398-
dc.description.abstractThere has been a constant demand for an animal model of advanced coronary atherosclerosis produced in a short period. It was known that mild atherosclerosis could be produced in various vascular beds by high cholesterol diets. However, it requires considerable time to produce advanced atherosclerotic lesions by diets alone. The current study was designed to investigate effects of combination of a balloon denudation procedure and high cholesterol diet in swine. The authors could produce advanced atherosclerotic lesions in coronary arteries in cholesterol fed swine within a short period of time by inserting a balloon catheter via carotid artery into the coronary artery, inflating it so as to distend the lumen, and pulling it back quickly, which resulted in extensive denudation of the endothelium of coronary arteries. An atherosclerosis like lesion develops at the site with eventual narrowing of the lumen leading to myocardial ischemia, myocardial infarction, and occasionally sudden death, thus resembling in many aspects human coronary artery disease. Among 22 swine studied, 10 had severe atherosclerosis with virtual occlusion of proximal portion of either or both coronary arteries and developed myocardial infarction within 2-3 months. Seven of these died suddenly, probably due to arrhythmia. This model should be appropriate for studies where advanced coronary atherosclerosis with its complications is needed.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexmpen_US
dc.relation.ispartofExperimental and Molecular Pathologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCholesterol, Dietaryen_US
dc.subject.meshCoronary Disease - Complications - Pathologyen_US
dc.subject.meshDisease Models, Animal - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMyocardial Infarction - Etiology - Pathologyen_US
dc.subject.meshSwineen_US
dc.subject.meshSwine Diseases - Pathologyen_US
dc.titleAdvanced coronary atherosclerosis in swine produced by combination of balloon catheter injury and cholesterol feedingen_US
dc.typeArticleen_US
dc.identifier.emailLee, WM: hrszlwm@hku.hken_US
dc.identifier.authorityLee, WM=rp00728en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0014-4800(75)90039-8-
dc.identifier.pmid1193215-
dc.identifier.scopuseid_2-s2.0-0016757960en_US
dc.identifier.volume23en_US
dc.identifier.issue3en_US
dc.identifier.spage491en_US
dc.identifier.epage499en_US
dc.identifier.isiWOS:A1975AZ68500010-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLee, WM=24799156600en_US
dc.identifier.scopusauthoridLee, KT=8054054000en_US

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