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Article: FEV 3, FEV 6 and their derivatives for detecting airflow obstruction in adult Chinese

TitleFEV 3, FEV 6 and their derivatives for detecting airflow obstruction in adult Chinese
Authors
KeywordsAirflow Obstruction
Chronic Obstructive Pulmonary Disease
Spirometry
Issue Date2012
PublisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.html
Citation
International Journal Of Tuberculosis And Lung Disease, 2012, v. 16 n. 5, p. 681-686 How to Cite?
AbstractBACKGROUND: Forced expiratory volume in 3 seconds (FEV 3) and 6 seconds (FEV 6) could complement FEV 1and forced vital capacity (FVC) for detecting airflow obstruction. OBJECTIVE: To compare FEV 1/FEV 6 and FEV 3/FVC with FEV 1/FVC in the detection of airflow obstruction. METHOD: Previous lung function data were re-analysed to establish reference values for FEV 3 and FEV 6. Data from a separate cohort of male smokers were used as test set. FEV 1, FEV 3, FEV 6, FVC, FEV 1/FVC, FEV 1/FEV 6 and FEV 3/FVC were regressed against age, standing height, weight and body mass index, and the mean and 95% confidence intervals for the lower limit of normal (LLN) values for these parameters were determined. RESULTS: The percentage of smokers with airflow obstruction in the test population using FEV 1/FVC < LLN was 15.0%, while using FEV 1/FEV 6 < LLN and FEV 3/FVC < LLN they were respectively 18.5% and 18.1%. Using FEV 1/FVC < LLN as reference, the sensitivity and specificity of FEV 1/FEV 6 < LLN in identifying airflow obstruction were 82.3% and 92.8%, while those for FEV 3/FVC < LLN were 78.5% and 92.6%; the positive and negative predictive values were 67% and 96.7% for FEV 1/FEV 6 < LLN and 65.3% and 96% for FEV 3/FVC < LLN. CONCLUSION: FEV 3/FVC < LLN and FEV 1/FEV 6 < LLN are comparable to FEV 1/FVC < LLN for detecting airflow obstruction. FEV 3/FVC < LLN could be useful in screening for airflow obstruction, while FEV 1/FEV 6 < LLN is useful in detecting airflow limitation in the elderly or in subjects with severe airflow obstruction. © 2012 The Union.
Persistent Identifierhttp://hdl.handle.net/10722/178313
ISSN
2015 Impact Factor: 2.148
2015 SCImago Journal Rankings: 1.381
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, CLDen_US
dc.contributor.authorFong, DYTen_US
dc.contributor.authorYu, WCen_US
dc.contributor.authorKo, FWSen_US
dc.contributor.authorLau, ACWen_US
dc.contributor.authorChan, JWMen_US
dc.contributor.authorChoo, KLen_US
dc.contributor.authorMok, TYWen_US
dc.contributor.authorTam, CYen_US
dc.contributor.authorIp, MSMen_US
dc.contributor.authorChanYeung, MMWen_US
dc.date.accessioned2012-12-19T09:45:13Z-
dc.date.available2012-12-19T09:45:13Z-
dc.date.issued2012en_US
dc.identifier.citationInternational Journal Of Tuberculosis And Lung Disease, 2012, v. 16 n. 5, p. 681-686en_US
dc.identifier.issn1027-3719en_US
dc.identifier.urihttp://hdl.handle.net/10722/178313-
dc.description.abstractBACKGROUND: Forced expiratory volume in 3 seconds (FEV 3) and 6 seconds (FEV 6) could complement FEV 1and forced vital capacity (FVC) for detecting airflow obstruction. OBJECTIVE: To compare FEV 1/FEV 6 and FEV 3/FVC with FEV 1/FVC in the detection of airflow obstruction. METHOD: Previous lung function data were re-analysed to establish reference values for FEV 3 and FEV 6. Data from a separate cohort of male smokers were used as test set. FEV 1, FEV 3, FEV 6, FVC, FEV 1/FVC, FEV 1/FEV 6 and FEV 3/FVC were regressed against age, standing height, weight and body mass index, and the mean and 95% confidence intervals for the lower limit of normal (LLN) values for these parameters were determined. RESULTS: The percentage of smokers with airflow obstruction in the test population using FEV 1/FVC < LLN was 15.0%, while using FEV 1/FEV 6 < LLN and FEV 3/FVC < LLN they were respectively 18.5% and 18.1%. Using FEV 1/FVC < LLN as reference, the sensitivity and specificity of FEV 1/FEV 6 < LLN in identifying airflow obstruction were 82.3% and 92.8%, while those for FEV 3/FVC < LLN were 78.5% and 92.6%; the positive and negative predictive values were 67% and 96.7% for FEV 1/FEV 6 < LLN and 65.3% and 96% for FEV 3/FVC < LLN. CONCLUSION: FEV 3/FVC < LLN and FEV 1/FEV 6 < LLN are comparable to FEV 1/FVC < LLN for detecting airflow obstruction. FEV 3/FVC < LLN could be useful in screening for airflow obstruction, while FEV 1/FEV 6 < LLN is useful in detecting airflow limitation in the elderly or in subjects with severe airflow obstruction. © 2012 The Union.en_US
dc.languageengen_US
dc.publisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.htmlen_US
dc.relation.ispartofInternational Journal of Tuberculosis and Lung Diseaseen_US
dc.subjectAirflow Obstructionen_US
dc.subjectChronic Obstructive Pulmonary Diseaseen_US
dc.subjectSpirometryen_US
dc.titleFEV 3, FEV 6 and their derivatives for detecting airflow obstruction in adult Chineseen_US
dc.typeArticleen_US
dc.identifier.emailFong, DYT: dytfong@hku.hken_US
dc.identifier.emailIp, MSM: msmip@hku.hken_US
dc.identifier.authorityFong, DYT=rp00253en_US
dc.identifier.authorityIp, MSM=rp00347en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.5588/ijtld.11.0283en_US
dc.identifier.pmid22507932-
dc.identifier.scopuseid_2-s2.0-84859729501en_US
dc.identifier.hkuros202202-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84859729501&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume16en_US
dc.identifier.issue5en_US
dc.identifier.spage681en_US
dc.identifier.epage686en_US
dc.identifier.eissn1815-7920-
dc.identifier.isiWOS:000303700600024-
dc.publisher.placeFranceen_US
dc.identifier.scopusauthoridLam, DCL=54896046800en_US
dc.identifier.scopusauthoridFong, DYT=35261710300en_US
dc.identifier.scopusauthoridYu, WC=7403914214en_US
dc.identifier.scopusauthoridKo, FWS=7103224911en_US
dc.identifier.scopusauthoridLau, ACW=7202626205en_US
dc.identifier.scopusauthoridChan, JWM=34967874700en_US
dc.identifier.scopusauthoridChoo, KL=23391819100en_US
dc.identifier.scopusauthoridMok, TYW=8706357200en_US
dc.identifier.scopusauthoridTam, CY=25423001100en_US
dc.identifier.scopusauthoridIp, MSM=7102423259en_US
dc.identifier.scopusauthoridChanYeung, MMW=54790582200en_US

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