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Article: Vertebral bone mineral density, marrow perfusion, and fat content in healthy men and men with osteoporosis: Dynamic contrast-enhanced MR imaging and MR spectroscopy

TitleVertebral bone mineral density, marrow perfusion, and fat content in healthy men and men with osteoporosis: Dynamic contrast-enhanced MR imaging and MR spectroscopy
Authors
Issue Date2005
PublisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.org
Citation
Radiology, 2005, v. 236 n. 3, p. 945-951 How to Cite?
AbstractPURPOSE: To prospectively use hydrogen 1 ( 1H) magnetic resonance (MR) spectroscopy and dynamic contrast material-enhanced MR imaging to measure vertebral body marrow fat content and bone marrow perfusion in older men with varying bone mineral densities as documented with dual x-ray absorptiometry (DXA). MATERIALS AND METHODS: This study had institutional review board approval, and all participants provided informed consent. DXA, 1H MR spectroscopy, and dynamic contrast-enhanced MR imaging of the lumbar spine were performed in 90 men (mean age, 73 years; range, 67-101 years). Vertebral marrow fat content and perfusion (maximum enhancement and enhancement slope) were compared for subject groups with differing bone densities (normal, osteopenic, and osteoporotic). The t test was used for comparisons between groups, and the Pearson test was used to determine correlation between marrow fat content and perfusion indexes. RESULTS: Eight subjects were excluded, yielding a final cohort of 82 subjects (mean age, 73 years; range, 67-101 years) that included 42 subjects with normal bone density (mean T score, 0.8 ± 1.1 [standard deviation]), 23 subjects with osteopenia (mean T score, -1.6 ± 0.4), and 17 subjects with osteoporosis (mean T score, -3.2 ± 0.5). Vertebral marrow fat content was significantly increased in subjects with osteoporosis (mean fat content, 58.23% ± 7.8) (P = .002) or osteopenia (mean fat content, 55.68% ± 10.2) (P = .034) compared with that in subjects with normal bone density (50.45% ± 8.7). Vertebral marrow perfusion indexes were significantly decreased in osteoporotic subjects (mean enhancement slope, 0.78%/ sec ± 0.3) compared with those in osteopenic subjects (mean enhancement slope, 1.15%/sec ± 0.6) (P = .007) and those in subjects with normal bone density (mean enhancement slope, 1.48%/sec ± 0.7) (P < .001). CONCLUSION: Subjects with osteoporosis have decreased vertebral marrow perfusion and increased marrow fat compared with these parameters in subjects with osteopenia. Similarly, subjects with osteopenia have decreased vertebral marrow perfusion and increased marrow fat compared with these parameters in subjects with normal bone density. © RSNA, 2005.
Persistent Identifierhttp://hdl.handle.net/10722/178278
ISSN
2015 Impact Factor: 6.798
2015 SCImago Journal Rankings: 3.414
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGriffith, JFen_US
dc.contributor.authorYeung, DKWen_US
dc.contributor.authorAntonio, GEen_US
dc.contributor.authorLee, FKHen_US
dc.contributor.authorHong, AWLen_US
dc.contributor.authorWong, SYSen_US
dc.contributor.authorLau, EMCen_US
dc.contributor.authorLeung, PCen_US
dc.date.accessioned2012-12-19T09:44:59Z-
dc.date.available2012-12-19T09:44:59Z-
dc.date.issued2005en_US
dc.identifier.citationRadiology, 2005, v. 236 n. 3, p. 945-951en_US
dc.identifier.issn0033-8419en_US
dc.identifier.urihttp://hdl.handle.net/10722/178278-
dc.description.abstractPURPOSE: To prospectively use hydrogen 1 ( 1H) magnetic resonance (MR) spectroscopy and dynamic contrast material-enhanced MR imaging to measure vertebral body marrow fat content and bone marrow perfusion in older men with varying bone mineral densities as documented with dual x-ray absorptiometry (DXA). MATERIALS AND METHODS: This study had institutional review board approval, and all participants provided informed consent. DXA, 1H MR spectroscopy, and dynamic contrast-enhanced MR imaging of the lumbar spine were performed in 90 men (mean age, 73 years; range, 67-101 years). Vertebral marrow fat content and perfusion (maximum enhancement and enhancement slope) were compared for subject groups with differing bone densities (normal, osteopenic, and osteoporotic). The t test was used for comparisons between groups, and the Pearson test was used to determine correlation between marrow fat content and perfusion indexes. RESULTS: Eight subjects were excluded, yielding a final cohort of 82 subjects (mean age, 73 years; range, 67-101 years) that included 42 subjects with normal bone density (mean T score, 0.8 ± 1.1 [standard deviation]), 23 subjects with osteopenia (mean T score, -1.6 ± 0.4), and 17 subjects with osteoporosis (mean T score, -3.2 ± 0.5). Vertebral marrow fat content was significantly increased in subjects with osteoporosis (mean fat content, 58.23% ± 7.8) (P = .002) or osteopenia (mean fat content, 55.68% ± 10.2) (P = .034) compared with that in subjects with normal bone density (50.45% ± 8.7). Vertebral marrow perfusion indexes were significantly decreased in osteoporotic subjects (mean enhancement slope, 0.78%/ sec ± 0.3) compared with those in osteopenic subjects (mean enhancement slope, 1.15%/sec ± 0.6) (P = .007) and those in subjects with normal bone density (mean enhancement slope, 1.48%/sec ± 0.7) (P < .001). CONCLUSION: Subjects with osteoporosis have decreased vertebral marrow perfusion and increased marrow fat compared with these parameters in subjects with osteopenia. Similarly, subjects with osteopenia have decreased vertebral marrow perfusion and increased marrow fat compared with these parameters in subjects with normal bone density. © RSNA, 2005.en_US
dc.languageengen_US
dc.publisherRadiological Society of North America, Inc. The Journal's web site is located at http://radiology.rsnajnls.orgen_US
dc.relation.ispartofRadiologyen_US
dc.subject.meshAbsorptiometry, Photonen_US
dc.subject.meshAdipose Tissue - Pathologyen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshBone Densityen_US
dc.subject.meshBone Marrow - Blood Supply - Pathologyen_US
dc.subject.meshContrast Mediaen_US
dc.subject.meshHumansen_US
dc.subject.meshImage Processing, Computer-Assisteden_US
dc.subject.meshMagnetic Resonance Imaging - Methodsen_US
dc.subject.meshMagnetic Resonance Spectroscopy - Methodsen_US
dc.subject.meshMaleen_US
dc.subject.meshOsteoporosis - Pathologyen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshSpine - Pathologyen_US
dc.titleVertebral bone mineral density, marrow perfusion, and fat content in healthy men and men with osteoporosis: Dynamic contrast-enhanced MR imaging and MR spectroscopyen_US
dc.typeArticleen_US
dc.identifier.emailHong, AWL: athenawl@hkucc.hku.hken_US
dc.identifier.authorityHong, AWL=rp00255en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1148/radiol.2363041425en_US
dc.identifier.pmid16055699-
dc.identifier.scopuseid_2-s2.0-23844554138en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-23844554138&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume236en_US
dc.identifier.issue3en_US
dc.identifier.spage945en_US
dc.identifier.epage951en_US
dc.identifier.isiWOS:000231412600027-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridGriffith, JF=7401497231en_US
dc.identifier.scopusauthoridYeung, DKW=35290812300en_US
dc.identifier.scopusauthoridAntonio, GE=7003714763en_US
dc.identifier.scopusauthoridLee, FKH=8687147400en_US
dc.identifier.scopusauthoridHong, AWL=8687147500en_US
dc.identifier.scopusauthoridWong, SYS=7404590959en_US
dc.identifier.scopusauthoridLau, EMC=7103086055en_US
dc.identifier.scopusauthoridLeung, PC=7401747829en_US

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