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Article: Increasing insulin resistance contributes to worsening glycaemic and lipid profiles in older Chinese subjects

TitleIncreasing insulin resistance contributes to worsening glycaemic and lipid profiles in older Chinese subjects
Authors
Issue Date2004
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/diabres
Citation
Diabetes Research And Clinical Practice, 2004, v. 64 n. 2, p. 123-128 How to Cite?
AbstractObjective: To investigate the impact of insulin resistance on cardiovascular risk factors in the elderly. Research design and methods: A cross-sectional, community-based study of 225 older Chinese participants (65-74 years, 55.6% female) recruited from community centres for the elderly in Shatin. Anthropometric measures and DXA body fat, blood pressure, insulin sensitivity (fasting insulin, fasting insulin-glucose product, short insulin tolerance test (SITT)), glycaemic (fasting glucose, glycated haemoglobin A1c) and lipid (total, HDL-, and LDL-cholesterol, triglycerides) indices and albuminuria (24h albumin-to-creatinine ratio) were measured. Results: There was a close correlation between the SITT and insulin-glucose product indices of insulin resistance. Decreasing tertiles of insulin sensitivity were associated with increasing indices of glycaemic control, and general and central obesity, including DXA lean and fat mass, albuminuria, and triglycerides, with decreasing HDL-cholesterol. There were no differences in blood pressure or electrolyte levels between these tertile groups. These subjects were more insulin resistant than a group of younger diabetics. Conclusions: Insulin resistance was associated with indices of obesity and an atherogenic lipid and hyperglycaemic profile and may in part contribute to the high frequency of metabolic syndrome components in these older Chinese subjects. © 2003 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/178275
ISSN
2015 Impact Factor: 3.045
2015 SCImago Journal Rankings: 1.338
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorThomas, GNen_US
dc.contributor.authorHong, AWLen_US
dc.contributor.authorTomlinson, Ben_US
dc.contributor.authorLam, CWKen_US
dc.contributor.authorCritchley, JAJHen_US
dc.contributor.authorSanderson, JEen_US
dc.contributor.authorWoo, Jen_US
dc.contributor.authorLau, Een_US
dc.date.accessioned2012-12-19T09:44:57Z-
dc.date.available2012-12-19T09:44:57Z-
dc.date.issued2004en_US
dc.identifier.citationDiabetes Research And Clinical Practice, 2004, v. 64 n. 2, p. 123-128en_US
dc.identifier.issn0168-8227en_US
dc.identifier.urihttp://hdl.handle.net/10722/178275-
dc.description.abstractObjective: To investigate the impact of insulin resistance on cardiovascular risk factors in the elderly. Research design and methods: A cross-sectional, community-based study of 225 older Chinese participants (65-74 years, 55.6% female) recruited from community centres for the elderly in Shatin. Anthropometric measures and DXA body fat, blood pressure, insulin sensitivity (fasting insulin, fasting insulin-glucose product, short insulin tolerance test (SITT)), glycaemic (fasting glucose, glycated haemoglobin A1c) and lipid (total, HDL-, and LDL-cholesterol, triglycerides) indices and albuminuria (24h albumin-to-creatinine ratio) were measured. Results: There was a close correlation between the SITT and insulin-glucose product indices of insulin resistance. Decreasing tertiles of insulin sensitivity were associated with increasing indices of glycaemic control, and general and central obesity, including DXA lean and fat mass, albuminuria, and triglycerides, with decreasing HDL-cholesterol. There were no differences in blood pressure or electrolyte levels between these tertile groups. These subjects were more insulin resistant than a group of younger diabetics. Conclusions: Insulin resistance was associated with indices of obesity and an atherogenic lipid and hyperglycaemic profile and may in part contribute to the high frequency of metabolic syndrome components in these older Chinese subjects. © 2003 Elsevier Ireland Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/diabresen_US
dc.relation.ispartofDiabetes Research and Clinical Practiceen_US
dc.subject.meshAgeden_US
dc.subject.meshAging - Blooden_US
dc.subject.meshAlbuminuriaen_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshCholesterol, Hdl - Blooden_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHyperglycemia - Etiologyen_US
dc.subject.meshHyperlipidemias - Etiologyen_US
dc.subject.meshInsulin Resistanceen_US
dc.subject.meshMaleen_US
dc.subject.meshObesity - Etiologyen_US
dc.subject.meshTriglycerides - Blooden_US
dc.titleIncreasing insulin resistance contributes to worsening glycaemic and lipid profiles in older Chinese subjectsen_US
dc.typeArticleen_US
dc.identifier.emailHong, AWL: athenawl@hkucc.hku.hken_US
dc.identifier.authorityHong, AWL=rp00255en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.diabres.2003.10.015en_US
dc.identifier.pmid15063605en_US
dc.identifier.scopuseid_2-s2.0-1842559842en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1842559842&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume64en_US
dc.identifier.issue2en_US
dc.identifier.spage123en_US
dc.identifier.epage128en_US
dc.identifier.isiWOS:000220938600007-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridThomas, GN=35465269900en_US
dc.identifier.scopusauthoridHong, AWL=8687147500en_US
dc.identifier.scopusauthoridTomlinson, B=16423466900en_US
dc.identifier.scopusauthoridLam, CWK=8531362100en_US
dc.identifier.scopusauthoridCritchley, JAJH=7102824658en_US
dc.identifier.scopusauthoridSanderson, JE=7202371250en_US
dc.identifier.scopusauthoridWoo, J=36040369400en_US
dc.identifier.scopusauthoridLau, E=7103086055en_US

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