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Article: Delay of the denervation process in skeletal muscle by sensory ganglion graft and its clinical application

TitleDelay of the denervation process in skeletal muscle by sensory ganglion graft and its clinical application
Authors
Issue Date1996
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.plasreconsurg.com
Citation
Plastic And Reconstructive Surgery, 1996, v. 97 n. 3, p. 577-586 How to Cite?
AbstractWe examined the effects of dorsal root ganglion isografts on the denervation process of skeletal muscle. A segment of sciatic nerve was removed from each of 25 inbred Wistar-Kyoto rats. Fifteen were set aside as controls. In the remaining 10 rats, isogeneic cervical dorsal root ganglia were grafted to the severed distal stump of the common peroneal nerve. Between day 72 and day 286 postoperatively, both controls and recipients were killed after twitch and tetanic tension recording of the extensor digitorum longus was performed. The wet muscle weight and the twitch and tetanic tensions of the denervated extensor digitorum longus in the graft group were significantly greater than those in the control group. The mean area of the denervated tibialis anterior muscle fibers in the graft group also was significantly larger than that in the control group. In electron and light microscopic images, nerve cells along the periphery of each dorsal root ganglion were found surviving with regenerating axons throughout the experimental period. Numerous myelinated axons were observed in the common peroneal nerve of the graft group, and there were significantly more axonal branches in the extensor digitorum longus of the graft group than in the extensor digitorum longus of the control group. Thus sensory nerve fibers from the grafted dorsal root ganglia had certain beneficial effects to slow the denervation process, presumably secreting trophic factors into the denervated muscle. Clinically, we have transferred avulsed dorsal root ganglia in cases of total brachial plexus avulsion directly into denervated skeletal muscle. This procedure, accompanied by nerve crossing procedures, will probably keep denervated skeletal muscle in a better condition until regenerating motor axons from the repair site reach their target muscle.
Persistent Identifierhttp://hdl.handle.net/10722/178209
ISSN
2015 Impact Factor: 3.087
2015 SCImago Journal Rankings: 1.986
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorOchi, Men_US
dc.contributor.authorKwong, WHen_US
dc.contributor.authorKimori, Ken_US
dc.contributor.authorTakemoto, Sen_US
dc.contributor.authorChow, SPen_US
dc.contributor.authorIkuta, Yen_US
dc.date.accessioned2012-12-19T09:43:27Z-
dc.date.available2012-12-19T09:43:27Z-
dc.date.issued1996en_US
dc.identifier.citationPlastic And Reconstructive Surgery, 1996, v. 97 n. 3, p. 577-586en_US
dc.identifier.issn0032-1052en_US
dc.identifier.urihttp://hdl.handle.net/10722/178209-
dc.description.abstractWe examined the effects of dorsal root ganglion isografts on the denervation process of skeletal muscle. A segment of sciatic nerve was removed from each of 25 inbred Wistar-Kyoto rats. Fifteen were set aside as controls. In the remaining 10 rats, isogeneic cervical dorsal root ganglia were grafted to the severed distal stump of the common peroneal nerve. Between day 72 and day 286 postoperatively, both controls and recipients were killed after twitch and tetanic tension recording of the extensor digitorum longus was performed. The wet muscle weight and the twitch and tetanic tensions of the denervated extensor digitorum longus in the graft group were significantly greater than those in the control group. The mean area of the denervated tibialis anterior muscle fibers in the graft group also was significantly larger than that in the control group. In electron and light microscopic images, nerve cells along the periphery of each dorsal root ganglion were found surviving with regenerating axons throughout the experimental period. Numerous myelinated axons were observed in the common peroneal nerve of the graft group, and there were significantly more axonal branches in the extensor digitorum longus of the graft group than in the extensor digitorum longus of the control group. Thus sensory nerve fibers from the grafted dorsal root ganglia had certain beneficial effects to slow the denervation process, presumably secreting trophic factors into the denervated muscle. Clinically, we have transferred avulsed dorsal root ganglia in cases of total brachial plexus avulsion directly into denervated skeletal muscle. This procedure, accompanied by nerve crossing procedures, will probably keep denervated skeletal muscle in a better condition until regenerating motor axons from the repair site reach their target muscle.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.plasreconsurg.comen_US
dc.relation.ispartofPlastic and Reconstructive Surgeryen_US
dc.subject.meshAnimalsen_US
dc.subject.meshGanglia, Spinal - Anatomy & Histology - Transplantationen_US
dc.subject.meshHumansen_US
dc.subject.meshMuscle Denervationen_US
dc.subject.meshMuscle Tonusen_US
dc.subject.meshMuscle, Skeletal - Innervation - Physiology - Surgeryen_US
dc.subject.meshPeroneal Nerve - Surgeryen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Wkyen_US
dc.subject.meshSciatic Nerve - Surgeryen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTransplantation, Isogeneicen_US
dc.titleDelay of the denervation process in skeletal muscle by sensory ganglion graft and its clinical applicationen_US
dc.typeArticleen_US
dc.identifier.emailChow, SP: spchow@hku.hken_US
dc.identifier.authorityChow, SP=rp00064en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00006534-199603000-00014en_US
dc.identifier.pmid8596789-
dc.identifier.scopuseid_2-s2.0-0030046174en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030046174&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume97en_US
dc.identifier.issue3en_US
dc.identifier.spage577en_US
dc.identifier.epage586en_US
dc.identifier.isiWOS:A1996TX71400014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridOchi, M=7201374971en_US
dc.identifier.scopusauthoridKwong, WH=35587275800en_US
dc.identifier.scopusauthoridKimori, K=6603288198en_US
dc.identifier.scopusauthoridTakemoto, S=16748149000en_US
dc.identifier.scopusauthoridChow, SP=7201828376en_US
dc.identifier.scopusauthoridIkuta, Y=16072878200en_US

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