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Conference Paper: A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels

TitleA single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels
Authors
KeywordsCardiovascular disease
Issue Date2012
PublisherHong Kong College of Cardiology. The Journal's web site is located at http://www.hkcchk.com/journals.php#3
Citation
The 16th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM), Hong Kong, 17 November 2012. In Journal of the Hong Kong College of Cardiology, 2012, v. 20 n. 2, p. 56, abstract no. P02 How to Cite?
AbstractOBJECTIVE: Plasma adrenomedullin (ADM) level is elevated in inflammation and is associated with cardiovascular diseases. Single nucleotide polymorphisms (SNPs) in the ADM gene have been found to be associated with ADM level. The 5'-flanking region of ADM is known to contain a consensus sequence of the binding site for the nuclear factor for interleukin-6 (IL-6). Therefore, we investigated if plasma ADM level is related to SNPs in the IL6 gene. METHODS: Plasma ADM level was measured in 476 subjects (236 men, 240 women; mean age 50.9±10.8 years) in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISP2). The subjects were genotyped for three tagging SNPs in the IL-6 gene. RESULTS: The minor allele frequencies of the IL-6 SNPs rs17147230, rs1800796 and rs2069837 were 41.8%, 20.0% and 15.4% respectively. The SNP rs17147230, was associated with plasma ADM level after adjusting for age and sex (β=-0.096, P=0.034). The association was significant in women (β=-0.115, P=0.021) but not in men. Amongst all subjects, plasma ADM level decreased with an increasing number of minor alleles of rs17147230 in multivariate analysis (P=0.034). Compared to subjects with AA genotype, subjects with TT genotype had a plasma ADM level 12.8% lower (95% CI: 0.6%-23.5%, P=0.041). CONCLUSION: Plasma ADM level is related to the SNP rs17147230 in IL-6 gene, and the association appears stronger in women. The effect of the polymorphism on inflammation and cardiovascular disease remains to be determined.
DescriptionPosters
Persistent Identifierhttp://hdl.handle.net/10722/177426
ISSN
2015 SCImago Journal Rankings: 0.102

 

DC FieldValueLanguage
dc.contributor.authorWong, HKen_US
dc.contributor.authorOng, KLen_US
dc.contributor.authorLeung, RYHen_US
dc.contributor.authorLam, THen_US
dc.contributor.authorThomas, GNen_US
dc.contributor.authorLam, KSLen_US
dc.contributor.authorCheung, BMYen_US
dc.date.accessioned2012-12-18T05:10:29Z-
dc.date.available2012-12-18T05:10:29Z-
dc.date.issued2012en_US
dc.identifier.citationThe 16th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM), Hong Kong, 17 November 2012. In Journal of the Hong Kong College of Cardiology, 2012, v. 20 n. 2, p. 56, abstract no. P02en_US
dc.identifier.issn1027-7811-
dc.identifier.urihttp://hdl.handle.net/10722/177426-
dc.descriptionPosters-
dc.description.abstractOBJECTIVE: Plasma adrenomedullin (ADM) level is elevated in inflammation and is associated with cardiovascular diseases. Single nucleotide polymorphisms (SNPs) in the ADM gene have been found to be associated with ADM level. The 5'-flanking region of ADM is known to contain a consensus sequence of the binding site for the nuclear factor for interleukin-6 (IL-6). Therefore, we investigated if plasma ADM level is related to SNPs in the IL6 gene. METHODS: Plasma ADM level was measured in 476 subjects (236 men, 240 women; mean age 50.9±10.8 years) in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISP2). The subjects were genotyped for three tagging SNPs in the IL-6 gene. RESULTS: The minor allele frequencies of the IL-6 SNPs rs17147230, rs1800796 and rs2069837 were 41.8%, 20.0% and 15.4% respectively. The SNP rs17147230, was associated with plasma ADM level after adjusting for age and sex (β=-0.096, P=0.034). The association was significant in women (β=-0.115, P=0.021) but not in men. Amongst all subjects, plasma ADM level decreased with an increasing number of minor alleles of rs17147230 in multivariate analysis (P=0.034). Compared to subjects with AA genotype, subjects with TT genotype had a plasma ADM level 12.8% lower (95% CI: 0.6%-23.5%, P=0.041). CONCLUSION: Plasma ADM level is related to the SNP rs17147230 in IL-6 gene, and the association appears stronger in women. The effect of the polymorphism on inflammation and cardiovascular disease remains to be determined.-
dc.languageengen_US
dc.publisherHong Kong College of Cardiology. The Journal's web site is located at http://www.hkcchk.com/journals.php#3-
dc.relation.ispartofJournal of the Hong Kong College of Cardiologyen_US
dc.subjectCardiovascular disease-
dc.titleA single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levelsen_US
dc.typeConference_Paperen_US
dc.identifier.emailWong, HK: u3001343@hku.hken_US
dc.identifier.emailOng, KL: okl2000@hku.hken_US
dc.identifier.emailLeung, RYH: yhleung@hkucc.hku.hken_US
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hken_US
dc.identifier.emailThomas, GN: neilt@hkucc.hku.hk-
dc.identifier.emailLam, KSL: ksllam@hku.hk-
dc.identifier.emailCheung, BMY: mycheung@hku.hk-
dc.identifier.authorityLam, TH=rp00326en_US
dc.identifier.authorityLam, KSL=rp00343en_US
dc.identifier.authorityCheung, BMY=rp01321en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros212524en_US
dc.identifier.volume20en_US
dc.identifier.issue2en_US
dc.identifier.spage56en_US
dc.identifier.epage56en_US
dc.publisher.placeHong Kong-
dc.description.otherThe 16th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM), Hong Kong, 17 November 2012. In Journal of the Hong Kong College of Cardiology, 2012, v. 20 n. 2, p. 56, abstract no. P02-

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