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  Patent History
  • Application
    PC T/CN2009001422 2009-12-11
  • Publication
    WO 2010066112 2010-06-17
Supplementary

published patent: siRNA COMPOSITIONS AND METHODS FOR POTENTLY INHIBITING VIRAL INFECTION

TitlesiRNA COMPOSITIONS AND METHODS FOR POTENTLY INHIBITING VIRAL INFECTION
Priority Date2008-12-11 US 12/121614P
Inventors
Issue Date2010
Citation
WO Published patent application WO 2010066112. World Intellectual Property Organization (WIPO), PatentScope, 2010 How to Cite?
AbstractNo antiviral regimen has been consistently successful in treating H5N1 virus infection. We demonstrate that a group of highly effective siRNAs targeting different H5N1 viral genes shares a unique motif, GGAGU/ ACUCC. We further demonstrate that the effectiveness of siRNAs containing this motif is not sequence specific. The results suggested that the structure of the unique motif is critical in determining the potency of siRNA-mediated protective effects against viral infection and this potent in vivo protection is associated with early productions of ss-defensin and IL-6 induced by the motif. Provided are methods and prophylactic and therapeutic agents useful against other viral infections in addition to the H5N1 influenza virus.
Persistent Identifierhttp://hdl.handle.net/10722/177144

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:39:13Z-
dc.date.available2012-11-30T08:39:13Z-
dc.date.issued2010-
dc.identifier.citationWO Published patent application WO 2010066112. World Intellectual Property Organization (WIPO), PatentScope, 2010en_HK
dc.identifier.urihttp://hdl.handle.net/10722/177144-
dc.description.abstractNo antiviral regimen has been consistently successful in treating H5N1 virus infection. We demonstrate that a group of highly effective siRNAs targeting different H5N1 viral genes shares a unique motif, GGAGU/ ACUCC. We further demonstrate that the effectiveness of siRNAs containing this motif is not sequence specific. The results suggested that the structure of the unique motif is critical in determining the potency of siRNA-mediated protective effects against viral infection and this potent in vivo protection is associated with early productions of ss-defensin and IL-6 induced by the motif. Provided are methods and prophylactic and therapeutic agents useful against other viral infections in addition to the H5N1 influenza virus.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titlesiRNA COMPOSITIONS AND METHODS FOR POTENTLY INHIBITING VIRAL INFECTIONen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorZheng, Ben_HK
dc.contributor.inventorSui, Hongyanen_HK
dc.contributor.inventorLin, Yongpingen_HK
patents.identifier.applicationPC T/CN2009001422en_HK
patents.description.assigneeUNIV HONG KONG [CN]; ZHENG BOJIAN [CN]; SUI HONGYAN [US]; LIN YONGPING [CN]en_HK
patents.description.countryWorld Intellectual Property Organization (WIPO)en_HK
patents.date.publication2010-06-17en_HK
patents.date.application2009-12-11en_HK
patents.date.priority2008-12-11 US 12/121614Pen_HK
patents.description.ccWOen_HK
patents.identifier.publicationWO 2010066112en_HK
patents.relation.familyCN 102203254 (A) 2011-09-28en_HK
patents.relation.familyEP 2356236 (A1) 2011-08-17en_HK
patents.relation.familyUS 2010166661 (A1) 2010-07-01en_HK
patents.relation.familyWO 2010066112 (A1) 2010-06-17en_HK
patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

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