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  Patent History
  • Application
    PC T/CN2009000791 2009-07-14
  • Publication
    WO 2010006508 2010-01-21
Supplementary

published patent: INTEGRIN PEPTIDE, ANTI-CD 18 ssA ANTIBODY FOR TREATMENT OF ENDOTOXIN-MEDIATED PRO-INFLAMMATORY RESPONSES AND THE USE

TitleINTEGRIN PEPTIDE, ANTI-CD 18 ssA ANTIBODY FOR TREATMENT OF ENDOTOXIN-MEDIATED PRO-INFLAMMATORY RESPONSES AND THE USE
Priority Date2008-07-14 US 12/080558P
Inventors
Issue Date2010
Citation
WO Published patent application WO 2010006508. World Intellectual Property Organization (WIPO), PatentScope, 2010 How to Cite?
AbstractBacterial lipopolysaccharide (LPS) in systemic circulation triggers deleterious super-inflammatory response, which is key pathogenesis of many disorders like gram-negative sepsis and necrotizing enterocolitis. No effective therapeutic interventions are currently available for protection of patients against mortality. Disclosed are methods and therapeutic agents that ablate the biological toxicity of LPS in circulation (Integrin Peptide), and abrogate leukocyte infiltration into lung and liver and suppress adhesion molecule expression (Integrin Peptide and Anti-CD 18 ssA scFv). These therapeutic agents can be used alone, or in combination for treatment of endotoxin-mediated pro-inflammatory responses, particularly in cases of acute sepsis and necrotizing enterocolitis.
Persistent Identifierhttp://hdl.handle.net/10722/177140
References

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:39:12Z-
dc.date.available2012-11-30T08:39:12Z-
dc.date.issued2010-
dc.identifier.citationWO Published patent application WO 2010006508. World Intellectual Property Organization (WIPO), PatentScope, 2010en_HK
dc.identifier.urihttp://hdl.handle.net/10722/177140-
dc.description.abstractBacterial lipopolysaccharide (LPS) in systemic circulation triggers deleterious super-inflammatory response, which is key pathogenesis of many disorders like gram-negative sepsis and necrotizing enterocolitis. No effective therapeutic interventions are currently available for protection of patients against mortality. Disclosed are methods and therapeutic agents that ablate the biological toxicity of LPS in circulation (Integrin Peptide), and abrogate leukocyte infiltration into lung and liver and suppress adhesion molecule expression (Integrin Peptide and Anti-CD 18 ssA scFv). These therapeutic agents can be used alone, or in combination for treatment of endotoxin-mediated pro-inflammatory responses, particularly in cases of acute sepsis and necrotizing enterocolitis.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleINTEGRIN PEPTIDE, ANTI-CD 18 ssA ANTIBODY FOR TREATMENT OF ENDOTOXIN-MEDIATED PRO-INFLAMMATORY RESPONSES AND THE USEen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorLuk, JMCen_HK
dc.contributor.inventorWong, Kwongfaien_HK
dc.contributor.inventorPoon, RTPen_HK
dc.contributor.inventorFan, STen_HK
patents.identifier.applicationPC T/CN2009000791en_HK
patents.description.assigneeUNIV HONG KONG [CN]; LUK MOONCHING JOHN [CN]; WONG KWONGFAI [CN]; POON TUNGPING RONNIE [CN]; FAN SHEUNGTAT [CN]en_HK
patents.description.countryWorld Intellectual Property Organization (WIPO)en_HK
patents.date.publication2010-01-21en_HK
dc.relation.referencesUS 2004005647 (A1) 2004-01-08en_HK
dc.relation.referencesUS 7183388 (B2) 2007-02-27en_HK
patents.date.application2009-07-14en_HK
patents.date.priority2008-07-14 US 12/080558Pen_HK
patents.description.ccWOen_HK
patents.identifier.publicationWO 2010006508en_HK
patents.relation.familyCN 102239179 (A) 2011-11-09en_HK
patents.relation.familyUS 2010008925 (A1) 2010-01-14en_HK
patents.relation.familyUS 7960338 (B2) 2011-06-14en_HK
patents.relation.familyWO 2010006508 (A1) 2010-01-21en_HK
patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

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