granted patent: METHODS FOR DETECTING DNA ORIGINATING FROM DIFFERENT INDIVIDUALS

TitleMETHODS FOR DETECTING DNA ORIGINATING FROM DIFFERENT INDIVIDUALS
Granted PatentUS 8168382
Granted Date2012-05-01
Priority Date2008-10-13 US 12/250480
2005-03-07 US 11/075092
2001-08-31 US 09/944951
Inventors
Issue Date30-Nov-2012
Citation
US Patent US 8168382. Washington, DC: US Patent and Trademark Office (USPTO), 2012 How to Cite?
AbstractIn a first aspect, the present invention features methods for differentiating DNA species originating from different individuals in a biological sample. These methods may be used to differentiate or detect fetal DNA in a maternal sample or to differentiate DNA of an organ donor from DNA of an organ recipient. In preferred embodiments, the DNA species are differentiated by observing epigenetic differences in the DNA species such as differences in DNA methylation. In a second aspect, the present invention features methods of detecting genetic abnormalities in a fetus by detecting fetal DNA in a biological sample obtained from a mother. In a third aspect, the present invention features methods for differentiating DNA species originating from an organ donor from those of an organ recipient.; In a fourth aspect, the present invention features kits for differentiating DNA species originating from different individuals in a biological sample.
Persistent Identifierhttp://hdl.handle.net/10722/177047
References

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:39:00Z-
dc.date.available2012-11-30T08:39:00Z-
dc.date.issued2012-11-30-
dc.identifier.citationUS Patent US 8168382. Washington, DC: US Patent and Trademark Office (USPTO), 2012en_HK
dc.identifier.urihttp://hdl.handle.net/10722/177047-
dc.description.abstractIn a first aspect, the present invention features methods for differentiating DNA species originating from different individuals in a biological sample. These methods may be used to differentiate or detect fetal DNA in a maternal sample or to differentiate DNA of an organ donor from DNA of an organ recipient. In preferred embodiments, the DNA species are differentiated by observing epigenetic differences in the DNA species such as differences in DNA methylation. In a second aspect, the present invention features methods of detecting genetic abnormalities in a fetus by detecting fetal DNA in a biological sample obtained from a mother. In a third aspect, the present invention features methods for differentiating DNA species originating from an organ donor from those of an organ recipient.; In a fourth aspect, the present invention features kits for differentiating DNA species originating from different individuals in a biological sample.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleMETHODS FOR DETECTING DNA ORIGINATING FROM DIFFERENT INDIVIDUALSen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorLo Yuk Ming Dennisen_HK
dc.contributor.inventorPoon, LLMen_HK
patents.identifier.applicationUS 12/250480en_HK
patents.identifier.grantedUS 8168382en_HK
patents.description.assigneeUNIV HONG KONG CHINESE [HK] en_HK
patents.description.countryUnited States of America en_HK
patents.date.granted2012-05-01en_HK
dc.relation.referencesUS 6017704 (A) 2000-01-25en_HK
dc.relation.referencesUS 6258540 (B1) 2001-07-10en_HK
dc.relation.referencesUS 6251594 (B1) 2001-06-26en_HK
dc.relation.referencesUS 6927028 (B2) 2005-08-09en_HK
dc.relation.referencesUS 2003044388 (A1) 2003-03-06 en_HK
dc.relation.referencesWO 9839474 (A1) 1998-09-11en_HK
patents.date.application2008-10-13en_HK
patents.date.priority2008-10-13 US 12/250480en_HK
patents.date.priority2005-03-07 US 11/075092en_HK
patents.date.priority2001-08-31 US 09/944951en_HK
patents.description.ccUSen_HK
patents.relation.familyAT 353977 (T) 2007-03-15en_HK
patents.relation.familyAU 2002324135 (A1) 2003-03-18en_HK
patents.relation.familyCA 2456140 (A1) 2003-03-13en_HK
patents.relation.familyCN 1665936 (A) 2005-09-07 en_HK
patents.relation.familyCN 100352939 (C) 2007-12-05en_HK
patents.relation.familyDE 60218182 (T2) 2008-02-07en_HK
patents.relation.familyDK 1421211 (T3) 2007-05-29en_HK
patents.relation.familyEP 1421211 (A2) 2004-05-26 en_HK
patents.relation.familyES 2280562 (T3) 2007-09-16en_HK
patents.relation.familyHK 1076840 (A1) 2008-05-23en_HK
patents.relation.familyJP 2005501566 (A) 2005-01-20en_HK
patents.relation.familyPT 1421211 (E) 2007-03-30en_HK
patents.relation.familyUS 2003044388 (A1) 2003-03-06 en_HK
patents.relation.familyUS 6927028 (B2) 2005-08-09en_HK
patents.relation.familyUS 2009170102 (A1) 2009-07-02 en_HK
patents.relation.familyUS 8168382 (B2) 2012-05-01en_HK
patents.relation.familyUS 2005282185 (A1) 2005-12-22en_HK
patents.relation.familyUS 2012190029 (A1) 2012-07-26en_HK
patents.relation.familyWO 03020974 (A2) 2003-03-13 en_HK
patents.description.kindB2en_HK
patents.typePatent_granteden_HK

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