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  Patent History
  • Application
    US 12/636234 2009-12-11
  • Publication
    US 2010166661 2010-07-01
Supplementary

published patent: siRNA COMPOSITIONS AND METHODS FOR POTENTLY INHIBITING VIRAL INFECTION

TitlesiRNA COMPOSITIONS AND METHODS FOR POTENTLY INHIBITING VIRAL INFECTION
Priority Date2009-12-11 US 12/636234
2008-12-11 US 12/121614P
Inventors
Issue Date2010
Citation
US Published patent application US 2010166661. Washington, DC: US Patent and Trademark Office (USPTO), 2010 How to Cite?
AbstractNo antiviral regimen has been consistently successful in treating H5N1 virus infection. We demonstrate that a group of highly effective siRNAs targeting different H5N1 viral genes shares a unique motif, GGAGU/ACUCC. We further demonstrate that the effectiveness of siRNAs containing this motif is not sequence specific. The results suggested that the structure of the unique motif is critical in determining the potency of siRNA-mediated protective effects against viral infection and this potent in vivo protection is associated with early productions of [beta]-defensin and IL-6 induced by the motif. Provided are methods and prophylactic and therapeutic agents useful against other viral infections in addition to the H5N1 influenza virus.
Persistent Identifierhttp://hdl.handle.net/10722/176998
References

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:55Z-
dc.date.available2012-11-30T08:38:55Z-
dc.date.issued2010-
dc.identifier.citationUS Published patent application US 2010166661. Washington, DC: US Patent and Trademark Office (USPTO), 2010en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176998-
dc.description.abstractNo antiviral regimen has been consistently successful in treating H5N1 virus infection. We demonstrate that a group of highly effective siRNAs targeting different H5N1 viral genes shares a unique motif, GGAGU/ACUCC. We further demonstrate that the effectiveness of siRNAs containing this motif is not sequence specific. The results suggested that the structure of the unique motif is critical in determining the potency of siRNA-mediated protective effects against viral infection and this potent in vivo protection is associated with early productions of [beta]-defensin and IL-6 induced by the motif. Provided are methods and prophylactic and therapeutic agents useful against other viral infections in addition to the H5N1 influenza virus.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titlesiRNA COMPOSITIONS AND METHODS FOR POTENTLY INHIBITING VIRAL INFECTIONen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorZheng, Ben_HK
dc.contributor.inventorSui Hongyanen_HK
dc.contributor.inventorLin Yongpingen_HK
patents.identifier.applicationUS 12/636234en_HK
patents.description.countryUnited States of Americaen_HK
patents.date.publication2010-07-01en_HK
dc.relation.referencesUS 2004242518 (A1) 2004-12-02-
patents.identifier.hkutechidMicro-2008-00295-1-
patents.date.application2009-12-11en_HK
patents.date.priority2009-12-11 US 12/636234en_HK
patents.date.priority2008-12-11 US 12/121614Pen_HK
patents.description.ccUSen_HK
patents.identifier.publicationUS 2010166661en_HK
patents.relation.familyCN 102203254 (A) 2011-09-28en_HK
patents.relation.familyEP 2356236 (A1) 2011-08-17en_HK
patents.relation.familyUS 2010166661 (A1) 2010-07-01en_HK
patents.relation.familyWO 2010066112 (A1) 2010-06-17en_HK
patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

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