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  Patent History
  • Application
    US 10/848736 2004-05-19
  • Publication
    US 2004235775 2004-11-25
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published patent: Inhibition of hepatitis B virus (HBV) replication by RNA interference

TitleInhibition of hepatitis B virus (HBV) replication by RNA interference
Priority Date2004-05-19 US 10/848736
2003-05-19 US 10/471903P
Inventors
Issue Date2004
Citation
US Published patent application US 2004235775. Washington, DC: US Patent and Trademark Office (USPTO), 2004 How to Cite?
AbstractThe present invention relates to the inhibition of Hepatitis B virus (HBV) replication by RNA molecules of the present invention. Specifically, the RNA molecules of the present invention are double-stranded ribonucleic acid molecules (dsRNA). Specifically, the invention relates to small interfering RNAs (siRNA) which are double-stranded RNAs that direct the sequence-specific degradation of messenger RNA in mammalian cells. The invention relates to development of a new anti-HBV therapy by inhibition of Hepatitis B Virus (HBV) replication using stably-expressed short hairpin RNAs (shRNA), which degrade HBV pregenomic RNA and message RNAs.; Included are methods of treatment of cancer by the administration of RNA molecules of the present invention in combination with surgery, alone or in further combination with standard and experimental chemotherapies, hormonal therapies, biological therapies/immunotherapies and/or radiation therapies.
Persistent Identifierhttp://hdl.handle.net/10722/176878

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:39Z-
dc.date.available2012-11-30T08:38:39Z-
dc.date.issued2004-
dc.identifier.citationUS Published patent application US 2004235775. Washington, DC: US Patent and Trademark Office (USPTO), 2004en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176878-
dc.description.abstractThe present invention relates to the inhibition of Hepatitis B virus (HBV) replication by RNA molecules of the present invention. Specifically, the RNA molecules of the present invention are double-stranded ribonucleic acid molecules (dsRNA). Specifically, the invention relates to small interfering RNAs (siRNA) which are double-stranded RNAs that direct the sequence-specific degradation of messenger RNA in mammalian cells. The invention relates to development of a new anti-HBV therapy by inhibition of Hepatitis B Virus (HBV) replication using stably-expressed short hairpin RNAs (shRNA), which degrade HBV pregenomic RNA and message RNAs.; Included are methods of treatment of cancer by the administration of RNA molecules of the present invention in combination with surgery, alone or in further combination with standard and experimental chemotherapies, hormonal therapies, biological therapies/immunotherapies and/or radiation therapies.en_HK
dc.relation.isreferencedbyUS 2009312531 (A1) 2009-12-17en_HK
dc.relation.isreferencedbyUS 7893224 (B2) 2011-02-22en_HK
dc.relation.isreferencedbyUS 2009318676 (A1) 2009-12-24en_HK
dc.relation.isreferencedbyUS 8013136 (B2) 2011-09-06en_HK
dc.relation.isreferencedbyUS 2009281298 (A1) 2009-11-12en_HK
dc.relation.isreferencedbyUS 7772387 (B2) 2010-08-10en_HK
dc.relation.isreferencedbyUS 8058448 (B2) 2011-11-15en_HK
dc.relation.isreferencedbyUS 2009187027 (A1) 2009-07-23en_HK
dc.relation.isreferencedbyGB 2439543 (A) 2008-01-02en_HK
dc.relation.isreferencedbyWO 2006023491 (A3) 2006-07-27en_HK
dc.relation.isreferencedbyWO 2006023491 (A2) 2006-03-02en_HK
dc.relation.isreferencedbyUS 2005288244 (A1) 2005-12-29en_HK
dc.relation.isreferencedbyUS 7674778 (B2) 2010-03-09en_HK
dc.relation.isreferencedbyUS 2006008822 (A1) 2006-01-12en_HK
dc.relation.isreferencedbyUS 7626014 (B2) 2009-12-01en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleInhibition of hepatitis B virus (HBV) replication by RNA interferenceen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorKung Hsiang-Fuen_HK
dc.contributor.inventorHe Ming-Liangen_HK
patents.identifier.applicationUS 10/848736en_HK
patents.description.assigneeKUNG HSIANG-FU, ; HE MING-LIANG, ; THE UNIVERSITY OF HONG KONGen_HK
patents.description.countryUnited States of Americaen_HK
patents.date.publication2004-11-25en_HK
patents.date.application2004-05-19en_HK
patents.date.priority2004-05-19 US 10/848736en_HK
patents.date.priority2003-05-19 US 10/471903Pen_HK
patents.description.ccUSen_HK
patents.identifier.publicationUS 2004235775en_HK
patents.relation.familyUS 2004235775 (A1) 2004-11-25en_HK
patents.relation.familyUS 7067249 (B2) 2006-06-27en_HK
patents.relation.familyUS 2005261094 (A1) 2005-11-24en_HK
patents.relation.familyUS 7354363 (B2) 2008-04-08en_HK
patents.relation.familyUS 2007027099 (A1) 2007-02-01en_HK
patents.description.kindA1en_HK
patents.typePatent_publisheden_HK

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