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  Patent History
  • Application
    CN 20088021520 2008-06-23
  • Publication
    CN 101715350 2010-05-26
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published patent: Strontium fortified calcium nano- and microparticle compositions and methods of making and using thereof

TitleStrontium fortified calcium nano- and microparticle compositions and methods of making and using thereof
Priority Date2008-06-23 PCT/CN2008001211
2007-06-22 US 11/945680P
Inventors
Issue Date2010
Citation
China Published Patent Application CN 101715350. Beijing, PRC: State Intellectual Property Office (SIPO) of the P.R.C., 2010 How to Cite?
AbstractCompositions containing strontium fortified calcium nanoparticles and/or microparticles, and methods of making and using thereof are described herein. The strontium fortified calcium compounds contain calcium ions, calcium atoms, strontium ions, strontium atoms, and combinations thereof and one or more anions. Exemplary anions include, but are not limited to, citrate, phosphate, carbonate, and combinations thereof. The particles can be formulated for enteral or parenteral administration by incorporating the particles into a pharmaceutically carrier. The compositions can further contain one or more active agents useful for bone diseases or disorders, such as vitamin D, growth factors, and combinations thereof. The compositions can be used to treat or prevent one or more bone diseases or disorders of the bone, such as osteoporosis. Alternatively, the particles can be coated onto a substrate, such as the surface of an implant. The coatings can be used to improved biocompatibility of the implant, prevent loosening of the implant, reducing leaching of metal ions from metallic implants, and reduce corrosion. The coatings can be applied to the substrate using a variety of techniques well known in the art. In one embodiment, the coating is applied using electrophoretic deposition. The use of nano- and/or microparticles that provide high surface area helps to improve interfacial strength between the coating and the implant, which allows for the use of lower sintering temperatures. Lowering sintering temperatures minimizes or prevents thermal decomposition of the coating material and/or degradation of the implant material.
Persistent Identifierhttp://hdl.handle.net/10722/176629

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:16Z-
dc.date.available2012-11-30T08:38:16Z-
dc.date.issued2010-
dc.identifier.citationChina Published Patent Application CN 101715350. Beijing, PRC: State Intellectual Property Office (SIPO) of the P.R.C., 2010en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176629-
dc.description.abstractCompositions containing strontium fortified calcium nanoparticles and/or microparticles, and methods of making and using thereof are described herein. The strontium fortified calcium compounds contain calcium ions, calcium atoms, strontium ions, strontium atoms, and combinations thereof and one or more anions. Exemplary anions include, but are not limited to, citrate, phosphate, carbonate, and combinations thereof. The particles can be formulated for enteral or parenteral administration by incorporating the particles into a pharmaceutically carrier. The compositions can further contain one or more active agents useful for bone diseases or disorders, such as vitamin D, growth factors, and combinations thereof. The compositions can be used to treat or prevent one or more bone diseases or disorders of the bone, such as osteoporosis. Alternatively, the particles can be coated onto a substrate, such as the surface of an implant. The coatings can be used to improved biocompatibility of the implant, prevent loosening of the implant, reducing leaching of metal ions from metallic implants, and reduce corrosion. The coatings can be applied to the substrate using a variety of techniques well known in the art. In one embodiment, the coating is applied using electrophoretic deposition. The use of nano- and/or microparticles that provide high surface area helps to improve interfacial strength between the coating and the implant, which allows for the use of lower sintering temperatures. Lowering sintering temperatures minimizes or prevents thermal decomposition of the coating material and/or degradation of the implant material.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleStrontium fortified calcium nano- and microparticle compositions and methods of making and using thereofen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorLu, WWen_HK
dc.contributor.inventorLi Zhaoyangen_HK
dc.contributor.inventorLam Wingmoon Raymonden_HK
dc.contributor.inventorLuk Dipkei Keithen_HK
patents.identifier.applicationCN 20088021520en_HK
patents.description.assigneeUNIV HONG KONGen_HK
patents.description.countryChina, PRCen_HK
patents.date.publication2010-05-26en_HK
patents.date.application2008-06-23en_HK
patents.date.priority2008-06-23 PCT/CN2008001211en_HK
patents.date.priority2007-06-22 US 11/945680Pen_HK
patents.description.ccCNen_HK
patents.identifier.publicationCN 101715350en_HK
patents.relation.familyCN 101715350 (A) 2010-05-26en_HK
patents.relation.familyEP 2164533 (A1) 2010-03-24en_HK
patents.relation.familyUS 2008317807 (A1) 2008-12-25en_HK
patents.relation.familyWO 2009000158 (A1) 2008-12-31en_HK
patents.description.kindAen_HK
patents.typePatent_publisheden_HK

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