published patent: Cell-matrix microspheres, methods for preparation and applications

TitleCell-matrix microspheres, methods for preparation and applications
Priority Date2006-05-19 US 11/801975P
Inventors
Issue Date2009
Citation
China Published Patent Application CN 101448527. Beijing, PRC: State Intellectual Property Office (SIPO) of the P.R.C., 2009 How to Cite?
AbstractA method has been developed to produce stable cell-matrix microspheres with up to 100% encapsulation efficiency and high cell viability, using matrix or biomaterial systems with poor shape and mechanical stability for applications including cell therapeutics via microinjection or surgical implantation, 3D culture for in vitro expansion without repeated cell splitting using enzymatic digestion or mechanical dissociation and for enhanced production of therapeutic biomolecules, and in vitro modelling for morphogenesis studies. The modified droplet generation method is simple and scalable and enables the production of cell-matrix microspheres when the matrix or biomaterial system used has low concentration, with slow phase transition, with poor shape and mechanical stability.
Persistent Identifierhttp://hdl.handle.net/10722/176620

 

DC FieldValueLanguage
dc.date.accessioned2012-11-30T08:38:15Z-
dc.date.available2012-11-30T08:38:15Z-
dc.date.issued2009-
dc.identifier.citationChina Published Patent Application CN 101448527. Beijing, PRC: State Intellectual Property Office (SIPO) of the P.R.C., 2009en_HK
dc.identifier.urihttp://hdl.handle.net/10722/176620-
dc.description.abstractA method has been developed to produce stable cell-matrix microspheres with up to 100% encapsulation efficiency and high cell viability, using matrix or biomaterial systems with poor shape and mechanical stability for applications including cell therapeutics via microinjection or surgical implantation, 3D culture for in vitro expansion without repeated cell splitting using enzymatic digestion or mechanical dissociation and for enhanced production of therapeutic biomolecules, and in vitro modelling for morphogenesis studies. The modified droplet generation method is simple and scalable and enables the production of cell-matrix microspheres when the matrix or biomaterial system used has low concentration, with slow phase transition, with poor shape and mechanical stability.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documentsen_US
dc.titleCell-matrix microspheres, methods for preparation and applicationsen_HK
dc.typePatenten_US
dc.description.naturepublished_or_final_versionen_US
dc.contributor.inventorChan, BPen_HK
dc.contributor.inventorWong Hoi Lingen_HK
dc.contributor.inventorCheung, PTen_HK
dc.contributor.inventorChan, Den_HK
patents.identifier.applicationCN 20078018296en_HK
patents.identifier.applicationZL200780018296.8-
patents.description.assigneeUNIV HONG KONG [HK]en_HK
patents.description.countryChina, PRCen_HK
patents.date.publication2009-06-03en_HK
patents.identifier.hkutechidME-2006-00213-2-
patents.date.application2007-05-18en_HK
patents.date.priority2006-05-19 US 11/801975Pen_HK
patents.description.ccCNen_HK
patents.identifier.publicationCN 101448527en_HK
patents.relation.familyCN 101448527 (A) 2009-06-03en_HK
patents.relation.familyEP 2021035 (A2) 2009-02-11en_HK
patents.relation.familyUS 2008031858 (A1) 2008-02-07en_HK
patents.relation.familyUS 2012148537 (A1) 2012-06-14en_HK
patents.relation.familyWO 2008075206 (A2) 2008-06-26en_HK
patents.description.kindAen_HK
patents.typePatent_publisheden_HK

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