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Article: Cost-effectiveness analysis at the development phase of a potential health technology: examples based on tissue engineering of bladder and urethra

TitleCost-effectiveness analysis at the development phase of a potential health technology: examples based on tissue engineering of bladder and urethra
Authors
Issue Date2007
PublisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www.wiley.com/WileyCDA/WileyTitle/productCd-TERM.html
Citation
Journal of Tissue Engineering and Regenerative Medicine, 2007, v. 1 n. 5, p. 343-349 How to Cite?
AbstractOBJECTIVES: We demonstrate the use of health economics to guide investment decisions in regenerative medicine. Our examples are based on proposed tissue engineering applications in the urinary tract. We show that health economics have a role in strengthening the supply side, not just the demand side of the health economy. METHODS: We reviewed the epidemiology and treatment of the clinical conditions where TE of urothelium may be considered using literature identified from a range of sources including electronic databases, article bibliographies and references, online articles and expert opinion in the field. RESULTS: Careful analysis of current best treatment suggested that urethral defects and bladder resection for cancer offered the most propitious applications of TE. The headroom for engineered urethral tissue was estimated at pound sterling186. This is unlikely to be large enough to support the launch of a TE product populated with viable cells. The headroom for TE bladder, on the other hand, was estimated at around pound sterling16 268. However, the market size is limited reducing potential profitability. CONCLUSIONS: The Headroom Method can help inform instrumental decisions concerning new treatments without having to build a complex model with very wide parameter uncertainty.
Persistent Identifierhttp://hdl.handle.net/10722/176513
ISSN
2015 Impact Factor: 4.71
2015 SCImago Journal Rankings: 0.920
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMcAteer, H-
dc.contributor.authorCosh, E-
dc.contributor.authorFreeman, G-
dc.contributor.authorPandit, A-
dc.contributor.authorWood, P-
dc.contributor.authorLilford, R-
dc.date.accessioned2012-11-30T07:00:01Z-
dc.date.available2012-11-30T07:00:01Z-
dc.date.issued2007-
dc.identifier.citationJournal of Tissue Engineering and Regenerative Medicine, 2007, v. 1 n. 5, p. 343-349-
dc.identifier.issn1932-6254-
dc.identifier.urihttp://hdl.handle.net/10722/176513-
dc.description.abstractOBJECTIVES: We demonstrate the use of health economics to guide investment decisions in regenerative medicine. Our examples are based on proposed tissue engineering applications in the urinary tract. We show that health economics have a role in strengthening the supply side, not just the demand side of the health economy. METHODS: We reviewed the epidemiology and treatment of the clinical conditions where TE of urothelium may be considered using literature identified from a range of sources including electronic databases, article bibliographies and references, online articles and expert opinion in the field. RESULTS: Careful analysis of current best treatment suggested that urethral defects and bladder resection for cancer offered the most propitious applications of TE. The headroom for engineered urethral tissue was estimated at pound sterling186. This is unlikely to be large enough to support the launch of a TE product populated with viable cells. The headroom for TE bladder, on the other hand, was estimated at around pound sterling16 268. However, the market size is limited reducing potential profitability. CONCLUSIONS: The Headroom Method can help inform instrumental decisions concerning new treatments without having to build a complex model with very wide parameter uncertainty.-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www.wiley.com/WileyCDA/WileyTitle/productCd-TERM.html-
dc.relation.ispartofJournal of Tissue Engineering and Regenerative Medicine-
dc.rightsJournal of Tissue Engineering and Regenerative Medicine. Copyright © John Wiley & Sons, Inc..-
dc.rightsSpecial Statement for Preprint only Before publication: 'This is a preprint of an article accepted for publication in [The Journal of Pathology] Copyright © ([year]) ([Pathological Society of Great Britain and Ireland])'. After publication: the preprint notice should be amended to follows: 'This is a preprint of an article published in [include the complete citation information for the final version of the Contribution as published in the print edition of the Journal]' For Cochrane Library/ Cochrane Database of Systematic Reviews, add statement & acknowledgement : ‘This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 20XX, Issue X. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.’ Please include reference to the Review and hyperlink to the original version using the following format e.g. Authors. Title of Review. Cochrane Database of Systematic Reviews 20XX, Issue #. Art. No.: CD00XXXX. DOI: 10.1002/14651858.CD00XXXX (insert persistent link to the article by using the URL: http://dx.doi.org/10.1002/14651858.CD00XXXX) (This statement should refer to the most recent issue of the Cochrane Database of Systematic Reviews in which the Review published.)-
dc.subject.meshBiomedical Technology - economics - statistics and numerical data - trends-
dc.subject.meshTissue Engineering - methods-
dc.subject.meshUrethra - abnormalities - cytology - surgery-
dc.subject.meshUrinary Bladder - cytology - surgery-
dc.subject.meshUrinary Bladder Neoplasms - therapy-
dc.titleCost-effectiveness analysis at the development phase of a potential health technology: examples based on tissue engineering of bladder and urethraen_US
dc.typeArticleen_US
dc.identifier.emailFreeman, G: gfreeman@hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/term.36-
dc.identifier.pmid18038428-
dc.identifier.scopuseid_2-s2.0-34848860560-
dc.identifier.volume1-
dc.identifier.issue5-
dc.identifier.spage343-
dc.identifier.epage349-
dc.identifier.isiWOS:000256520100002-
dc.publisher.placeUnited States-

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