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Article: Scanning laser polarimetry in pulmonary tuberculosis patients on chemotherapy

TitleScanning laser polarimetry in pulmonary tuberculosis patients on chemotherapy
Authors
Issue Date2006
PublisherAcademy of Medicine Singapore. The Journal's web site is located at http://www.annals.edu.sg
Citation
Annals Of The Academy Of Medicine Singapore, 2006, v. 35 n. 6, p. 395-399 How to Cite?
AbstractIntroduction: The aim of this study was to analyse the thickness of the retinal nerve fibre layer (RNFL) of pulmonary tuberculosis patients on ethambutol and isoniazid. Materials and Methods: This was a prospective cohort study where patients with newly diagnosed pulmonary tuberculosis requiring chemotherapy, including ethambutol and isoniazid, were imaged using scanning laser polarimetry. Their mean baseline RNFL thickness and various scanning laser polarimetry parameters of both eyes were measured 2 weeks after the commencement of chemotherapy. The measurements were repeated at 3 months and 6 months after treatment. The various parameters of the baseline and the follow-up measurements were compared using paired sample t-test with Bonferroni correction. Results: Twenty-four patients (16 males and 8 females; mean age, 51.0 ± 17.6 years) were recruited. There was no statistically significant difference between the baseline and the follow-up measurements in RNFL thickness and all other scanning laser polarimetry parameters. Conclusion: In this cohort of subjects, there was no subclinical change in RNFL thickness detected by scanning laser polarimetry in pulmonary tuberculosis patients on chemotherapy, including ethambutol and isoniazid, after 6 months of treatment.
Persistent Identifierhttp://hdl.handle.net/10722/176453
ISSN
2015 Impact Factor: 1.041
2015 SCImago Journal Rankings: 0.425
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, WWTen_US
dc.contributor.authorLai, JSMen_US
dc.contributor.authorTham, CCYen_US
dc.contributor.authorChan, KKen_US
dc.contributor.authorChan, KSen_US
dc.date.accessioned2012-11-26T09:11:22Z-
dc.date.available2012-11-26T09:11:22Z-
dc.date.issued2006en_US
dc.identifier.citationAnnals Of The Academy Of Medicine Singapore, 2006, v. 35 n. 6, p. 395-399en_US
dc.identifier.issn0304-4602en_US
dc.identifier.urihttp://hdl.handle.net/10722/176453-
dc.description.abstractIntroduction: The aim of this study was to analyse the thickness of the retinal nerve fibre layer (RNFL) of pulmonary tuberculosis patients on ethambutol and isoniazid. Materials and Methods: This was a prospective cohort study where patients with newly diagnosed pulmonary tuberculosis requiring chemotherapy, including ethambutol and isoniazid, were imaged using scanning laser polarimetry. Their mean baseline RNFL thickness and various scanning laser polarimetry parameters of both eyes were measured 2 weeks after the commencement of chemotherapy. The measurements were repeated at 3 months and 6 months after treatment. The various parameters of the baseline and the follow-up measurements were compared using paired sample t-test with Bonferroni correction. Results: Twenty-four patients (16 males and 8 females; mean age, 51.0 ± 17.6 years) were recruited. There was no statistically significant difference between the baseline and the follow-up measurements in RNFL thickness and all other scanning laser polarimetry parameters. Conclusion: In this cohort of subjects, there was no subclinical change in RNFL thickness detected by scanning laser polarimetry in pulmonary tuberculosis patients on chemotherapy, including ethambutol and isoniazid, after 6 months of treatment.en_US
dc.languageengen_US
dc.publisherAcademy of Medicine Singapore. The Journal's web site is located at http://www.annals.edu.sgen_US
dc.relation.ispartofAnnals of the Academy of Medicine Singaporeen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAntitubercular Agents - Adverse Effects - Therapeutic Useen_US
dc.subject.meshDiagnostic Techniques, Ophthalmologicalen_US
dc.subject.meshEthambutol - Adverse Effects - Therapeutic Useen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIsoniazid - Adverse Effects - Therapeutic Useen_US
dc.subject.meshLasers - Diagnostic Useen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRetinal Diseases - Chemically Induced - Diagnosisen_US
dc.subject.meshTuberculosis, Pulmonary - Drug Therapyen_US
dc.titleScanning laser polarimetry in pulmonary tuberculosis patients on chemotherapyen_US
dc.typeArticleen_US
dc.identifier.emailLai, JSM: laism@hku.hken_US
dc.identifier.authorityLai, JSM=rp00295en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.pmid16865189-
dc.identifier.scopuseid_2-s2.0-33748593386en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33748593386&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume35en_US
dc.identifier.issue6en_US
dc.identifier.spage395en_US
dc.identifier.epage399en_US
dc.identifier.isiWOS:000239814200004-
dc.publisher.placeSingaporeen_US
dc.identifier.scopusauthoridTang, WWT=7403431228en_US
dc.identifier.scopusauthoridLai, JSM=7401939748en_US
dc.identifier.scopusauthoridTham, CCY=7006081241en_US
dc.identifier.scopusauthoridChan, KK=35073540100en_US
dc.identifier.scopusauthoridChan, KS=7406031627en_US

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