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Article: Chorioretinal topography and histopathology in laser-induced choroidal neovascularization

TitleChorioretinal topography and histopathology in laser-induced choroidal neovascularization
Authors
Issue Date2003
Citation
Ophthalmic Surgery And Lasers, 2003, v. 34 n. 1, p. 38-43 How to Cite?
AbstractOBJECTIVE: To investigate the correspondence between topographic mapping of the vitreoretinal and chorioretinal surfaces in vivo and histopathology findings. MATERIALS AND METHODS: Choroidal neovascularization was induced in the retina of a primate by an argon laser. Serial optical section images of the retina were obtained using an optical imaging system based on the Retinal Thickness Analyzer. Topography of the vitreoretinal and chorioretinal surfaces was mapped. The animal was killed and the eyes enucleated for histopathologic examination. RESULTS: In the normal retina, the topography of the vitreoretinal surface showed a depression at the center of the fovea while the chorioretinal surface was relatively flat, corresponding to normal anatomy. In the retina with choroidal neovascularization, the topography of the vitreoretinal surface indicated a smooth elevation while there were irregular elevations in the topography of the chorioretinal surface. Histological sections displayed focal serous retinal detachment, metaplasia of retinal pigment epithelium, and choroidal neovascularization. CONCLUSION: Topographic mapping of the vitreoretinal and chorioretinal surfaces in vivo corresponds with histological findings and shows promise for quantitative evaluation of pathologic alterations caused by chorioretinal diseases.
Persistent Identifierhttp://hdl.handle.net/10722/176397
ISSN
2005 Impact Factor: 0.249
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLai, WWen_US
dc.contributor.authorShahidi, Men_US
dc.contributor.authorMori, Men_US
dc.contributor.authorPulido, JSen_US
dc.date.accessioned2012-11-26T09:11:00Z-
dc.date.available2012-11-26T09:11:00Z-
dc.date.issued2003en_US
dc.identifier.citationOphthalmic Surgery And Lasers, 2003, v. 34 n. 1, p. 38-43en_US
dc.identifier.issn1082-3069en_US
dc.identifier.urihttp://hdl.handle.net/10722/176397-
dc.description.abstractOBJECTIVE: To investigate the correspondence between topographic mapping of the vitreoretinal and chorioretinal surfaces in vivo and histopathology findings. MATERIALS AND METHODS: Choroidal neovascularization was induced in the retina of a primate by an argon laser. Serial optical section images of the retina were obtained using an optical imaging system based on the Retinal Thickness Analyzer. Topography of the vitreoretinal and chorioretinal surfaces was mapped. The animal was killed and the eyes enucleated for histopathologic examination. RESULTS: In the normal retina, the topography of the vitreoretinal surface showed a depression at the center of the fovea while the chorioretinal surface was relatively flat, corresponding to normal anatomy. In the retina with choroidal neovascularization, the topography of the vitreoretinal surface indicated a smooth elevation while there were irregular elevations in the topography of the chorioretinal surface. Histological sections displayed focal serous retinal detachment, metaplasia of retinal pigment epithelium, and choroidal neovascularization. CONCLUSION: Topographic mapping of the vitreoretinal and chorioretinal surfaces in vivo corresponds with histological findings and shows promise for quantitative evaluation of pathologic alterations caused by chorioretinal diseases.en_US
dc.languageengen_US
dc.relation.ispartofOphthalmic Surgery and Lasersen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChoroid - Pathologyen_US
dc.subject.meshChoroidal Neovascularization - Etiology - Pathologyen_US
dc.subject.meshDiagnostic Techniques, Ophthalmologicalen_US
dc.subject.meshFluorescein Angiographyen_US
dc.subject.meshFundus Oculien_US
dc.subject.meshLasers - Adverse Effectsen_US
dc.subject.meshModels, Animalen_US
dc.subject.meshPapioen_US
dc.subject.meshRetina - Pathologyen_US
dc.titleChorioretinal topography and histopathology in laser-induced choroidal neovascularizationen_US
dc.typeArticleen_US
dc.identifier.emailLai, WW: wicolai@hku.hken_US
dc.identifier.authorityLai, WW=rp00531en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid12570003-
dc.identifier.scopuseid_2-s2.0-0037252861en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037252861&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume34en_US
dc.identifier.issue1en_US
dc.identifier.spage38en_US
dc.identifier.epage43en_US
dc.identifier.isiWOS:000184623800006-
dc.identifier.scopusauthoridLai, WW=7402231098en_US
dc.identifier.scopusauthoridShahidi, M=7003985405en_US
dc.identifier.scopusauthoridMori, M=7404717856en_US
dc.identifier.scopusauthoridPulido, JS=20135697200en_US

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