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Article: Effect of intracameral acetylcholine on latanoprost in preventing ocular hypertension after phacoemulsification and intraocular lens implantation

TitleEffect of intracameral acetylcholine on latanoprost in preventing ocular hypertension after phacoemulsification and intraocular lens implantation
Authors
Issue Date2001
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jcrs
Citation
Journal Of Cataract And Refractive Surgery, 2001, v. 27 n. 5, p. 700-705 How to Cite?
AbstractPurpose: To evaluate the effect of intracameral acetylcholine on latanoprost in preventing ocular hypertension in the early period after phacoemulsification with posterior chamber intraocular lens (PC IOL) implantation. Setting: Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Shatin, Hong Kong, China. Methods: Patients with uncomplicated cataract having phacoemulsification with PC IOL implantation were included in this prospective randomized double-masked clinical trial. The eyes were randomly assigned to 1 of 4 groups based on postoperative application of latanoprost 0.005% alone (Group 1), latanoprost 0.005% with intracameral acetylcholine (Group 2), intracameral acetylcholine alone (Group 3), and no medication (controls (Group 4). Intraocular pressure (IOP) was measured 3 and 24 hours postoperatively. The anterior chamber was examined for the level of cells and flare using slitlamp biomicroscopy. Results: Three and 24 hours after surgery, the decrease in mean IOP in eyes receiving latanoprost alone was not statistically significantly different from that in control eyes (P > .05). Eyes receiving intracameral acetylcholine alone had a significant decrease in the mean IOP at 3 hours (P < .05) but not at 24 hours compared to control eyes (P > .05). There were no significant differences in the mean postoperative IOP decrease between eyes receiving latanoprost with intracameral acetylcholine and those receiving intracamerat acetylcholine alone (P > .05). Conclusions: A single application of latanoprost did not significantly lower IOP in the first 24 hours after phacoemulsification with PC IOL implantation. Eyes receiving intracameral acetylcholine alone had a significantly greater decrease in IOP than control eyes at 3 hours but not at 24 hours. The addition of intracameral acetylcholine to latanoprost did not enhance or reduce latanoprost's IOP-lowering effect.
Persistent Identifierhttp://hdl.handle.net/10722/176372
ISSN
2015 Impact Factor: 3.02
2015 SCImago Journal Rankings: 1.946
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLai, JSMen_US
dc.contributor.authorChua, JKHen_US
dc.contributor.authorLoo, Aen_US
dc.contributor.authorHo, SYen_US
dc.contributor.authorLam, DSCen_US
dc.date.accessioned2012-11-26T09:10:52Z-
dc.date.available2012-11-26T09:10:52Z-
dc.date.issued2001en_US
dc.identifier.citationJournal Of Cataract And Refractive Surgery, 2001, v. 27 n. 5, p. 700-705en_US
dc.identifier.issn0886-3350en_US
dc.identifier.urihttp://hdl.handle.net/10722/176372-
dc.description.abstractPurpose: To evaluate the effect of intracameral acetylcholine on latanoprost in preventing ocular hypertension in the early period after phacoemulsification with posterior chamber intraocular lens (PC IOL) implantation. Setting: Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Shatin, Hong Kong, China. Methods: Patients with uncomplicated cataract having phacoemulsification with PC IOL implantation were included in this prospective randomized double-masked clinical trial. The eyes were randomly assigned to 1 of 4 groups based on postoperative application of latanoprost 0.005% alone (Group 1), latanoprost 0.005% with intracameral acetylcholine (Group 2), intracameral acetylcholine alone (Group 3), and no medication (controls (Group 4). Intraocular pressure (IOP) was measured 3 and 24 hours postoperatively. The anterior chamber was examined for the level of cells and flare using slitlamp biomicroscopy. Results: Three and 24 hours after surgery, the decrease in mean IOP in eyes receiving latanoprost alone was not statistically significantly different from that in control eyes (P > .05). Eyes receiving intracameral acetylcholine alone had a significant decrease in the mean IOP at 3 hours (P < .05) but not at 24 hours compared to control eyes (P > .05). There were no significant differences in the mean postoperative IOP decrease between eyes receiving latanoprost with intracameral acetylcholine and those receiving intracamerat acetylcholine alone (P > .05). Conclusions: A single application of latanoprost did not significantly lower IOP in the first 24 hours after phacoemulsification with PC IOL implantation. Eyes receiving intracameral acetylcholine alone had a significantly greater decrease in IOP than control eyes at 3 hours but not at 24 hours. The addition of intracameral acetylcholine to latanoprost did not enhance or reduce latanoprost's IOP-lowering effect.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jcrsen_US
dc.relation.ispartofJournal of Cataract and Refractive Surgeryen_US
dc.subject.meshAcetylcholine - Administration & Dosage - Therapeutic Useen_US
dc.subject.meshAgeden_US
dc.subject.meshAntihypertensive Agents - Administration & Dosage - Therapeutic Useen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshDrug Synergismen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIntraocular Pressure - Drug Effectsen_US
dc.subject.meshLens Implantation, Intraocular - Adverse Effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshOcular Hypertension - Etiology - Prevention & Controlen_US
dc.subject.meshOphthalmic Solutionsen_US
dc.subject.meshPhacoemulsification - Adverse Effectsen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshProstaglandins F, Synthetic - Administration & Dosage - Therapeutic Useen_US
dc.titleEffect of intracameral acetylcholine on latanoprost in preventing ocular hypertension after phacoemulsification and intraocular lens implantationen_US
dc.typeArticleen_US
dc.identifier.emailLai, JSM: laism@hku.hken_US
dc.identifier.authorityLai, JSM=rp00295en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0886-3350(00)00729-Xen_US
dc.identifier.pmid11377899-
dc.identifier.scopuseid_2-s2.0-0035008461en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035008461&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume27en_US
dc.identifier.issue5en_US
dc.identifier.spage700en_US
dc.identifier.epage705en_US
dc.identifier.isiWOS:000168786600019-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLai, JSM=7401939748en_US
dc.identifier.scopusauthoridChua, JKH=7005163724en_US
dc.identifier.scopusauthoridLoo, A=7003815216en_US
dc.identifier.scopusauthoridHo, SY=36839067000en_US
dc.identifier.scopusauthoridLam, DSC=35500200200en_US

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