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Article: Effect of bombesin on plasma insulin, pancreatic glucagon, and gut glucagon in man

TitleEffect of bombesin on plasma insulin, pancreatic glucagon, and gut glucagon in man
Authors
Issue Date1983
PublisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.org
Citation
Journal Of Clinical Endocrinology And Metabolism, 1983, v. 56 n. 4, p. 643-647 How to Cite?
AbstractThe effect of bombesin on insulin, pancreatic glucagon, and gut glucagon was investigated in eight healthy volunteers and two pancreatectomized patients. Bombesin, infused iv at the constant rate of 5 ng kg-1, produced a sharp and statistically significant rise in the plasma insulin concentration. The peak was reached at 5 min (26 ± 2.17 μU/ml; P<0.005 vs. basal values), followed by a prolonged and statistically significant (P<0.05) decrease in blood glucose. Pancreatic glucagon rapidly rose to a maximal value of 80.5 ± 7.6 pmol/liter (P<0.005 vs. basal values). In contrast with the prompt increase in insulin and glucagon plasma levels, the peak in gut glucagon concentration (55.8 ± 4.6 pmol/liter; P<0.005 vs. basal values) was reached 30 min after bombesin infusion was discontinued. In the two pancreatectomized patients, bombesin induced an increase in gut glucagon concentrations only. The results presented indicate that bombesin acts directly on the A and B cells of the pancreas, influencing glucose homeostasis; however, more complex mechanisms seem to be involved in gut glucagon secretion.
Persistent Identifierhttp://hdl.handle.net/10722/176238
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.940
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBruzzone, Ren_US
dc.contributor.authorTamburrano, Gen_US
dc.contributor.authorLala, Aen_US
dc.date.accessioned2012-11-26T09:07:29Z-
dc.date.available2012-11-26T09:07:29Z-
dc.date.issued1983en_US
dc.identifier.citationJournal Of Clinical Endocrinology And Metabolism, 1983, v. 56 n. 4, p. 643-647en_US
dc.identifier.issn0021-972Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/176238-
dc.description.abstractThe effect of bombesin on insulin, pancreatic glucagon, and gut glucagon was investigated in eight healthy volunteers and two pancreatectomized patients. Bombesin, infused iv at the constant rate of 5 ng kg-1, produced a sharp and statistically significant rise in the plasma insulin concentration. The peak was reached at 5 min (26 ± 2.17 μU/ml; P<0.005 vs. basal values), followed by a prolonged and statistically significant (P<0.05) decrease in blood glucose. Pancreatic glucagon rapidly rose to a maximal value of 80.5 ± 7.6 pmol/liter (P<0.005 vs. basal values). In contrast with the prompt increase in insulin and glucagon plasma levels, the peak in gut glucagon concentration (55.8 ± 4.6 pmol/liter; P<0.005 vs. basal values) was reached 30 min after bombesin infusion was discontinued. In the two pancreatectomized patients, bombesin induced an increase in gut glucagon concentrations only. The results presented indicate that bombesin acts directly on the A and B cells of the pancreas, influencing glucose homeostasis; however, more complex mechanisms seem to be involved in gut glucagon secretion.en_US
dc.languageengen_US
dc.publisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.orgen_US
dc.relation.ispartofJournal of Clinical Endocrinology and Metabolismen_US
dc.subject.meshAdulten_US
dc.subject.meshBlood Glucose - Metabolismen_US
dc.subject.meshBombesin - Diagnostic Use - Pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlucagon - Blood - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshInsulin - Blooden_US
dc.subject.meshIntestines - Metabolismen_US
dc.subject.meshKineticsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPancreas - Metabolismen_US
dc.subject.meshPancreatectomyen_US
dc.subject.meshPeptides - Pharmacologyen_US
dc.titleEffect of bombesin on plasma insulin, pancreatic glucagon, and gut glucagon in manen_US
dc.typeArticleen_US
dc.identifier.emailBruzzone, R: bruzzone@hkucc.hku.hken_US
dc.identifier.authorityBruzzone, R=rp01442en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid6339534-
dc.identifier.scopuseid_2-s2.0-0020695980en_US
dc.identifier.volume56en_US
dc.identifier.issue4en_US
dc.identifier.spage643en_US
dc.identifier.epage647en_US
dc.identifier.isiWOS:A1983QH26600001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridBruzzone, R=7006793327en_US
dc.identifier.scopusauthoridTamburrano, G=7004520843en_US
dc.identifier.scopusauthoridLala, A=7005955912en_US

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