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Conference Paper: Gene-environment interaction analysis of serotonin system markers with adolescent depression

TitleGene-environment interaction analysis of serotonin system markers with adolescent depression
Authors
Issue Date2004
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/mp
Citation
Molecular Psychiatry, 2004, v. 9 n. 10, p. 908-915 How to Cite?
AbstractWe report analyses from a study of gene-environment interaction in adolescent depression. The sample was selected from 1990 adolescents aged 10-20 years: those with depression symptoms in the top or bottom 15% were identified and divided into high or low environmental risk groups. DNA was obtained from 377 adolescents, representing the four quadrants of high or low depression and high or low environmental risk. Markers within, or close to, each of the serotonergic genes 5HTT, HTR2A, HTR2C, MAOA (monoamine oxidase type A) and tryptophan hydroxylase (TPH) were genotyped. Environmental risk group was a nonsignificant predictor and sex was a significant predictor of the depression group. HTR2A and TPH significantly predicted the depression group, independent of the effects of sex, environmental risk group and their interaction. In addition, there was a trend for an effect of 5HTTLPR, which was significant in female subjects. Furthermore, there was a significant genotype-environmental risk interaction for 5HTTLPR in female subjects only, with the effect being in the same direction as another recent study, reaffirming that an important source of genetic heterogeneity is exposure to environmental risk.
Persistent Identifierhttp://hdl.handle.net/10722/176092
ISSN
2015 Impact Factor: 13.314
2015 SCImago Journal Rankings: 6.790
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorEley, TCen_US
dc.contributor.authorSugden, Ken_US
dc.contributor.authorCorsico, Aen_US
dc.contributor.authorGregory, AMen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorMcguffin, Pen_US
dc.contributor.authorPlomin, Ren_US
dc.contributor.authorCraig, IWen_US
dc.date.accessioned2012-11-26T09:05:34Z-
dc.date.available2012-11-26T09:05:34Z-
dc.date.issued2004en_US
dc.identifier.citationMolecular Psychiatry, 2004, v. 9 n. 10, p. 908-915en_US
dc.identifier.issn1359-4184en_US
dc.identifier.urihttp://hdl.handle.net/10722/176092-
dc.description.abstractWe report analyses from a study of gene-environment interaction in adolescent depression. The sample was selected from 1990 adolescents aged 10-20 years: those with depression symptoms in the top or bottom 15% were identified and divided into high or low environmental risk groups. DNA was obtained from 377 adolescents, representing the four quadrants of high or low depression and high or low environmental risk. Markers within, or close to, each of the serotonergic genes 5HTT, HTR2A, HTR2C, MAOA (monoamine oxidase type A) and tryptophan hydroxylase (TPH) were genotyped. Environmental risk group was a nonsignificant predictor and sex was a significant predictor of the depression group. HTR2A and TPH significantly predicted the depression group, independent of the effects of sex, environmental risk group and their interaction. In addition, there was a trend for an effect of 5HTTLPR, which was significant in female subjects. Furthermore, there was a significant genotype-environmental risk interaction for 5HTTLPR in female subjects only, with the effect being in the same direction as another recent study, reaffirming that an important source of genetic heterogeneity is exposure to environmental risk.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/mpen_US
dc.relation.ispartofMolecular Psychiatryen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdolescent Psychologyen_US
dc.subject.meshAdulten_US
dc.subject.meshBiological Markersen_US
dc.subject.meshChilden_US
dc.subject.meshDepression - Etiology - Geneticsen_US
dc.subject.meshEnvironmenten_US
dc.subject.meshFamily Healthen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Heterogeneityen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshLife Change Eventsen_US
dc.subject.meshMaleen_US
dc.subject.meshMembrane Glycoproteins - Geneticsen_US
dc.subject.meshMembrane Transport Proteins - Geneticsen_US
dc.subject.meshMonoamine Oxidase - Geneticsen_US
dc.subject.meshNerve Tissue Proteins - Geneticsen_US
dc.subject.meshPromoter Regions, Genetic - Geneticsen_US
dc.subject.meshQuestionnairesen_US
dc.subject.meshReceptor, Serotonin, 5-Ht2a - Geneticsen_US
dc.subject.meshReceptor, Serotonin, 5-Ht2c - Geneticsen_US
dc.subject.meshRisken_US
dc.subject.meshSerotonin - Metabolismen_US
dc.subject.meshSerotonin Plasma Membrane Transport Proteinsen_US
dc.subject.meshSex Factorsen_US
dc.subject.meshTryptophan Hydroxylase - Geneticsen_US
dc.titleGene-environment interaction analysis of serotonin system markers with adolescent depressionen_US
dc.typeConference_Paperen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/sj.mp.4001546en_US
dc.identifier.pmid15241435-
dc.identifier.scopuseid_2-s2.0-6044228097en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-6044228097&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume9en_US
dc.identifier.issue10en_US
dc.identifier.spage908en_US
dc.identifier.epage915en_US
dc.identifier.isiWOS:000224092100005-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridEley, TC=7003787769en_US
dc.identifier.scopusauthoridSugden, K=36765392300en_US
dc.identifier.scopusauthoridCorsico, A=7003664783en_US
dc.identifier.scopusauthoridGregory, AM=7103300229en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridMcGuffin, P=22954119700en_US
dc.identifier.scopusauthoridPlomin, R=36050187200en_US
dc.identifier.scopusauthoridCraig, IW=7102548208en_US
dc.identifier.citeulike5423025-

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