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Conference Paper: The mode of action of colloidal bismuth subcitrate

TitleThe mode of action of colloidal bismuth subcitrate
Authors
Issue Date1991
Citation
Scandinavian Journal Of Gastroenterology, Supplement, 1991, v. 26 n. 185, p. 1-6 How to Cite?
AbstractColloidal bismuth subcitrate (CBS) is very effective in the treatment of gastroduodenal disorders and appears to act via several mechanisms. It has little acid-neutralizing effect and does not affect acid secretion. It is uncertain whether CBS affects pepsin secretion, but it does inhibit peptic activity. It cases an increase in mucus glycoprotein secretion and may also bind to the gastric mucus layer to act as a diffusion barrier to HCl. CBS accelerates ulcer healing and causes an accumulation of epidermal growth factor around the ulcer. In addition, it has a cytoprotective effect and increases mucosal secretion of prostaglandins and bicarbonate. CBS has bactericidal effects against Helicobacter pylori (which is associated with gastritis and peptic ulcers). It also prevents adhesion of H. pylori to epithelial cells and can inhibit enzymes secreted by H. pylori, such as proteases, lipases, glycosidases, and phospholipases.
Persistent Identifierhttp://hdl.handle.net/10722/176087
ISSN
2013 SCImago Journal Rankings: 0.122

 

DC FieldValueLanguage
dc.contributor.authorLee, SPen_US
dc.date.accessioned2012-11-26T09:05:32Z-
dc.date.available2012-11-26T09:05:32Z-
dc.date.issued1991en_US
dc.identifier.citationScandinavian Journal Of Gastroenterology, Supplement, 1991, v. 26 n. 185, p. 1-6en_US
dc.identifier.issn0085-5928en_US
dc.identifier.urihttp://hdl.handle.net/10722/176087-
dc.description.abstractColloidal bismuth subcitrate (CBS) is very effective in the treatment of gastroduodenal disorders and appears to act via several mechanisms. It has little acid-neutralizing effect and does not affect acid secretion. It is uncertain whether CBS affects pepsin secretion, but it does inhibit peptic activity. It cases an increase in mucus glycoprotein secretion and may also bind to the gastric mucus layer to act as a diffusion barrier to HCl. CBS accelerates ulcer healing and causes an accumulation of epidermal growth factor around the ulcer. In addition, it has a cytoprotective effect and increases mucosal secretion of prostaglandins and bicarbonate. CBS has bactericidal effects against Helicobacter pylori (which is associated with gastritis and peptic ulcers). It also prevents adhesion of H. pylori to epithelial cells and can inhibit enzymes secreted by H. pylori, such as proteases, lipases, glycosidases, and phospholipases.en_US
dc.languageengen_US
dc.relation.ispartofScandinavian Journal of Gastroenterology, Supplementen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Ulcer Agents - Pharmacology - Therapeutic Useen_US
dc.subject.meshColloidsen_US
dc.subject.meshGastric Acid - Secretionen_US
dc.subject.meshGastric Mucosa - Drug Effectsen_US
dc.subject.meshHelicobacter Infections - Drug Therapyen_US
dc.subject.meshHelicobacter Pylori - Drug Effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshMucus - Drug Effectsen_US
dc.subject.meshOrganometallic Compounds - Pharmacology - Therapeutic Useen_US
dc.subject.meshPepsin A - Physiologyen_US
dc.subject.meshPeptic Ulcer - Drug Therapyen_US
dc.titleThe mode of action of colloidal bismuth subcitrateen_US
dc.typeConference_Paperen_US
dc.identifier.emailLee, SP: sumlee@hku.hken_US
dc.identifier.authorityLee, SP=rp01351en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1957120-
dc.identifier.scopuseid_2-s2.0-0025812311en_US
dc.identifier.volume26en_US
dc.identifier.issue185en_US
dc.identifier.spage1en_US
dc.identifier.epage6en_US
dc.publisher.placeNorwayen_US
dc.identifier.scopusauthoridLee, SP=7601417497en_US

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