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Article: Are auditory P300 and duration MMN heritable and putative endophenotypes of psychotic bipolar disorder? A Maudsley Bipolar Twin and Family Study

TitleAre auditory P300 and duration MMN heritable and putative endophenotypes of psychotic bipolar disorder? A Maudsley Bipolar Twin and Family Study
Authors
Issue Date2009
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
Citation
Psychological Medicine, 2009, v. 39 n. 8, p. 1277-1287 How to Cite?
AbstractBackground. Impaired P300 auditory response has been reported in patients with psychotic bipolar disorder (BPD) and unaffected relatives of psychotic bipolar patients. Deficits in mismatch negativity (MMN), however, have not been observed in bipolar patients. To our knowledge, no family study of MMN in BPD has been reported. The current study combined the Maudsley twin and bipolar family samples using genetic model fitting analyses to: (1) assess the relationship between BPD and MMN, (2) substantiate the association between psychotic BPD and P300 variables, (3) verify the genetic overlap of BPD with P300 amplitude previously reported in the twin sample, and (4) examine the shared genetic influences between BPD and bilateral temporal scalp locations of P300 components. Method. A total of 301 subjects were included in this study, including 94 twin pairs, 31 bipolar families, and 39 unrelated healthy controls. Statistical analyses were based on structural equation modelling. Results. Both P300 and MMN are heritable, with heritability estimates of 0.58 for MMN, 0.68-0.80 for P300 amplitude, and 0.21-0.56 for P300 latency. The bipolar patients and their relatives showed normal MMN. No significant association, either genetic or environmental, was found with BPD. BPD was significantly associated with reduced P300 amplitude and prolonged latency on midline and bilateral temporal-posterior scalp areas. Shared genetic factors were the main source of these associations. Conclusions. The results confirm that MMN is not an endophenotype for psychotic BPD whereas P300 amplitude and latency components are valid endophenotypes for psychotic BPD. © 2009 Cambridge University Press.
Persistent Identifierhttp://hdl.handle.net/10722/175979
ISSN
2015 Impact Factor: 5.491
2015 SCImago Journal Rankings: 2.843
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHall, MHen_US
dc.contributor.authorSchulze, Ken_US
dc.contributor.authorRijsdijk, Fen_US
dc.contributor.authorKalidindi, Sen_US
dc.contributor.authorMcdonald, Cen_US
dc.contributor.authorBramon, Een_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorSham, Pen_US
dc.date.accessioned2012-11-26T09:03:11Z-
dc.date.available2012-11-26T09:03:11Z-
dc.date.issued2009en_US
dc.identifier.citationPsychological Medicine, 2009, v. 39 n. 8, p. 1277-1287en_US
dc.identifier.issn0033-2917en_US
dc.identifier.urihttp://hdl.handle.net/10722/175979-
dc.description.abstractBackground. Impaired P300 auditory response has been reported in patients with psychotic bipolar disorder (BPD) and unaffected relatives of psychotic bipolar patients. Deficits in mismatch negativity (MMN), however, have not been observed in bipolar patients. To our knowledge, no family study of MMN in BPD has been reported. The current study combined the Maudsley twin and bipolar family samples using genetic model fitting analyses to: (1) assess the relationship between BPD and MMN, (2) substantiate the association between psychotic BPD and P300 variables, (3) verify the genetic overlap of BPD with P300 amplitude previously reported in the twin sample, and (4) examine the shared genetic influences between BPD and bilateral temporal scalp locations of P300 components. Method. A total of 301 subjects were included in this study, including 94 twin pairs, 31 bipolar families, and 39 unrelated healthy controls. Statistical analyses were based on structural equation modelling. Results. Both P300 and MMN are heritable, with heritability estimates of 0.58 for MMN, 0.68-0.80 for P300 amplitude, and 0.21-0.56 for P300 latency. The bipolar patients and their relatives showed normal MMN. No significant association, either genetic or environmental, was found with BPD. BPD was significantly associated with reduced P300 amplitude and prolonged latency on midline and bilateral temporal-posterior scalp areas. Shared genetic factors were the main source of these associations. Conclusions. The results confirm that MMN is not an endophenotype for psychotic BPD whereas P300 amplitude and latency components are valid endophenotypes for psychotic BPD. © 2009 Cambridge University Press.en_US
dc.languageengen_US
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSMen_US
dc.relation.ispartofPsychological Medicineen_US
dc.subject.meshAcoustic Stimulationen_US
dc.subject.meshAdulten_US
dc.subject.meshBipolar Disorder - Diagnosis - Genetics - Physiopathology - Psychologyen_US
dc.subject.meshCerebral Cortex - Physiopathologyen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshContingent Negative Variation - Geneticsen_US
dc.subject.meshDiseases In Twins - Diagnosis - Genetics - Physiopathology - Psychologyen_US
dc.subject.meshDominance, Cerebral - Genetics - Physiologyen_US
dc.subject.meshElectrocardiographyen_US
dc.subject.meshEnglanden_US
dc.subject.meshEvent-Related Potentials, P300 - Genetics - Physiologyen_US
dc.subject.meshEvoked Potentials, Auditory - Genetics - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshModels, Geneticen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshPsychiatric Status Rating Scalesen_US
dc.subject.meshReaction Time - Genetics - Physiologyen_US
dc.subject.meshSignal Processing, Computer-Assisteden_US
dc.subject.meshSocial Environmenten_US
dc.subject.meshStatistics As Topicen_US
dc.subject.meshTwins, Dizygotic - Genetics - Psychologyen_US
dc.subject.meshTwins, Monozygotic - Genetics - Psychologyen_US
dc.titleAre auditory P300 and duration MMN heritable and putative endophenotypes of psychotic bipolar disorder? A Maudsley Bipolar Twin and Family Studyen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1017/S0033291709005261en_US
dc.identifier.pmid19250581-
dc.identifier.scopuseid_2-s2.0-69549102877en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-69549102877&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume39en_US
dc.identifier.issue8en_US
dc.identifier.spage1277en_US
dc.identifier.epage1287en_US
dc.identifier.isiWOS:000268165300006-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.f10001164987-
dc.identifier.scopusauthoridHall, MH=14013171900en_US
dc.identifier.scopusauthoridSchulze, K=7103137549en_US
dc.identifier.scopusauthoridRijsdijk, F=6701830835en_US
dc.identifier.scopusauthoridKalidindi, S=24366595400en_US
dc.identifier.scopusauthoridMcDonald, C=8749594800en_US
dc.identifier.scopusauthoridBramon, E=8089378900en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US

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