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Article: Concordance rates and biometrical model fitting for operational diagnoses in the maudsley twin psychosis series

TitleConcordance rates and biometrical model fitting for operational diagnoses in the maudsley twin psychosis series
Authors
Issue Date1998
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 1998, v. 81 n. 6, p. 456-457 How to Cite?
AbstractBackground: Twin studies have supported a genetic contribution to the major categories of psychotic illness, but few of these have employed operational diagnostic criteria, and no study using such criteria has been based on a sample that includes the full range of functional psychotic illnesses. Objectives: To investigate concordance rates and perform biometrical model fitting for operationallydefined psychotic diagnoses in a sample of twins with any functional psychosis. Methods: 224 twin probands (106 MZ, 118 DZ) with a same-sex co-twin and a lifetime history of psychotic symptomatology were ascertained from the service-based Maudsley Twin Register, in London. RDC psychotic diagnoses were made on a lifetime-ever basis. Main-lifetime diagnoses of DSMIIIR and ICD10 schizophrenia were also made. Probandwise concordance rates and correlations in liability were calculated, and biometrical model fitting applied. Results: A genetic contribution to variance in liability was confirmed for the major diagnostic categories except RDC depressive psychosis and unspecified functional psychosis, where familial transmission was confirmed, but the relative contribution of genetic and common environmental factors was unclear. Heritability estimates were: 82% for RDC schizophrenia; 85% for RDC schizoaffective disorders; 83% for all RDC affective psychoses; 84% for RDC mania; 89% for all RDC psychotic diagnoses; 84% for DSMIIIR schizophrenia; and 83% for ICD10 schizophrenia. Conclusions: Heritability estimates for schizophrenia, schizoaffective disorders, mania, and all psychoses combined were substantial and similar. Population morbid risk estimates were inferred rather than directly measured, but the results were very similar to those from studies where morbid risks were directly estimated.
Persistent Identifierhttp://hdl.handle.net/10722/175958
ISSN
2015 Impact Factor: 3.391
2015 SCImago Journal Rankings: 1.771

 

DC FieldValueLanguage
dc.contributor.authorCardno, AGen_US
dc.contributor.authorMarshall, EJen_US
dc.contributor.authorMacdonald, AMen_US
dc.contributor.authorCoid, Ben_US
dc.contributor.authorRibchester, TRen_US
dc.contributor.authorDavies, NJen_US
dc.contributor.authorVenturi, Pen_US
dc.contributor.authorJones, LAen_US
dc.contributor.authorLewis, SWen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorGottesman, IIen_US
dc.contributor.authorFarmer, AEen_US
dc.contributor.authorMcguffin, Pen_US
dc.contributor.authorReveley, AMen_US
dc.contributor.authorMurray, RMen_US
dc.date.accessioned2012-11-26T09:02:54Z-
dc.date.available2012-11-26T09:02:54Z-
dc.date.issued1998en_US
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 1998, v. 81 n. 6, p. 456-457en_US
dc.identifier.issn1552-4841en_US
dc.identifier.urihttp://hdl.handle.net/10722/175958-
dc.description.abstractBackground: Twin studies have supported a genetic contribution to the major categories of psychotic illness, but few of these have employed operational diagnostic criteria, and no study using such criteria has been based on a sample that includes the full range of functional psychotic illnesses. Objectives: To investigate concordance rates and perform biometrical model fitting for operationallydefined psychotic diagnoses in a sample of twins with any functional psychosis. Methods: 224 twin probands (106 MZ, 118 DZ) with a same-sex co-twin and a lifetime history of psychotic symptomatology were ascertained from the service-based Maudsley Twin Register, in London. RDC psychotic diagnoses were made on a lifetime-ever basis. Main-lifetime diagnoses of DSMIIIR and ICD10 schizophrenia were also made. Probandwise concordance rates and correlations in liability were calculated, and biometrical model fitting applied. Results: A genetic contribution to variance in liability was confirmed for the major diagnostic categories except RDC depressive psychosis and unspecified functional psychosis, where familial transmission was confirmed, but the relative contribution of genetic and common environmental factors was unclear. Heritability estimates were: 82% for RDC schizophrenia; 85% for RDC schizoaffective disorders; 83% for all RDC affective psychoses; 84% for RDC mania; 89% for all RDC psychotic diagnoses; 84% for DSMIIIR schizophrenia; and 83% for ICD10 schizophrenia. Conclusions: Heritability estimates for schizophrenia, schizoaffective disorders, mania, and all psychoses combined were substantial and similar. Population morbid risk estimates were inferred rather than directly measured, but the results were very similar to those from studies where morbid risks were directly estimated.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/en_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_US
dc.titleConcordance rates and biometrical model fitting for operational diagnoses in the maudsley twin psychosis seriesen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-33749102033en_US
dc.identifier.volume81en_US
dc.identifier.issue6en_US
dc.identifier.spage456en_US
dc.identifier.epage457en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCardno, AG=7004499892en_US
dc.identifier.scopusauthoridMarshall, EJ=10339840400en_US
dc.identifier.scopusauthoridMacdonald, AM=35557766100en_US
dc.identifier.scopusauthoridCoid, B=6507977783en_US
dc.identifier.scopusauthoridRibchester, TR=6506172219en_US
dc.identifier.scopusauthoridDavies, NJ=7202610654en_US
dc.identifier.scopusauthoridVenturi, P=6603816251en_US
dc.identifier.scopusauthoridJones, LA=34769954100en_US
dc.identifier.scopusauthoridLewis, SW=7404041267en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridGottesman, II=7005588519en_US
dc.identifier.scopusauthoridFarmer, AE=7102158824en_US
dc.identifier.scopusauthoridMcGuffin, P=22954119700en_US
dc.identifier.scopusauthoridReveley, AM=6701641246en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US

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