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Article: Correlation and familial aggregation of dimensions of psychosis in affected sibling pairs

TitleCorrelation and familial aggregation of dimensions of psychosis in affected sibling pairs
Authors
Issue Date2001
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 2001, v. 105 n. 7, p. 596 How to Cite?
AbstractWe measured the familial aggregation of clinical and demographic features and symptom dimensions of schizophrenia in 136 families with two or more affected members. Each affected member was assessed for lifetime worst positive and negative symptoms, general psychopathology, aggression, premorbid schizotypy and schizoid traits, type of onset, global functioning and developmental and demographic variables. We used two analytical methods: calculation of an intraclass correlation coefficient and evaluation of components of variance using the QTDT program. With either method, we found that global functioning, positive symptoms and global psychopathology, premorbid schizotypal and schizoid traits and premorbid social adjustment all showed significant evidence of familial aggregation. We found close correlation between clinical measures: 1) Worse pre-morbid social adjustment and pre-morbid schizoid and schizotypal traits were correlated with more severe symptoms, worse general psychopathology, poorer global functioning, more severe negative symptoms, and delayed early motor development; 2) Less severe pre-morbid schizoid and schizotypal trait scores were associated with more positive symptoms and 3) Chronic onset of illness was associated with more negative symptoms.
Persistent Identifierhttp://hdl.handle.net/10722/175957
ISSN
2015 Impact Factor: 3.391
2015 SCImago Journal Rankings: 1.771

 

DC FieldValueLanguage
dc.contributor.authorLi, Ten_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorCai, Gen_US
dc.contributor.authorLiu, Xen_US
dc.contributor.authorWickham, Hen_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorCollier, DAen_US
dc.date.accessioned2012-11-26T09:02:53Z-
dc.date.available2012-11-26T09:02:53Z-
dc.date.issued2001en_US
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 2001, v. 105 n. 7, p. 596en_US
dc.identifier.issn1552-4841en_US
dc.identifier.urihttp://hdl.handle.net/10722/175957-
dc.description.abstractWe measured the familial aggregation of clinical and demographic features and symptom dimensions of schizophrenia in 136 families with two or more affected members. Each affected member was assessed for lifetime worst positive and negative symptoms, general psychopathology, aggression, premorbid schizotypy and schizoid traits, type of onset, global functioning and developmental and demographic variables. We used two analytical methods: calculation of an intraclass correlation coefficient and evaluation of components of variance using the QTDT program. With either method, we found that global functioning, positive symptoms and global psychopathology, premorbid schizotypal and schizoid traits and premorbid social adjustment all showed significant evidence of familial aggregation. We found close correlation between clinical measures: 1) Worse pre-morbid social adjustment and pre-morbid schizoid and schizotypal traits were correlated with more severe symptoms, worse general psychopathology, poorer global functioning, more severe negative symptoms, and delayed early motor development; 2) Less severe pre-morbid schizoid and schizotypal trait scores were associated with more positive symptoms and 3) Chronic onset of illness was associated with more negative symptoms.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/en_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_US
dc.titleCorrelation and familial aggregation of dimensions of psychosis in affected sibling pairsen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-33749092768en_US
dc.identifier.volume105en_US
dc.identifier.issue7en_US
dc.identifier.spage596en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLi, T=36072008200en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridCai, G=15134875600en_US
dc.identifier.scopusauthoridLiu, X=7409286408en_US
dc.identifier.scopusauthoridWickham, H=6701762103en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridCollier, DA=26642980600en_US

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