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Article: A behavioural genomic analysis of DNA markers associated with general cognitive ability in 7-year-olds

TitleA behavioural genomic analysis of DNA markers associated with general cognitive ability in 7-year-olds
Authors
Issue Date2005
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JCPP
Citation
Journal Of Child Psychology And Psychiatry And Allied Disciplines, 2005, v. 46 n. 10, p. 1097-1107 How to Cite?
AbstractBackground: Five DNA markers (single-nucleotide polymorphisms, SNPs) have recently been found to be associated with general cognitive ability ('g') in a sample of 7414 7-year-old twins. These children have also been studied at 2, 3, 4, and 7 years of age on measures of cognitive and language development and behaviour problems; family environment was also assessed. Methods: We used these data to conduct a behavioural genomic analysis of the five SNPs and a composite of them ('SNP set') that explored developmental, multivariate, and genotype-environment (GE) issues. Results: The 'g' SNP set identified at 7 years yielded significant associations with 'g' as early as 2 years. In multivariate analyses at 7 years, the 'g' SNP set was more strongly associated with verbal than nonverbal ability and with reading more than mathematics performance. GE correlations were found between the SNP set for 'g' at 7 years and preschool proximal measures of the family environment (chaos and discipline) rather than distal measures (maternal education and father's occupational class), suggesting evocative rather than passive GE correlation. Significant GE interactions were found for discipline, education and occupation in which the association between the SNP set and 'g' at 7 years is stronger in low-risk environments. Conclusions: Al though the effect sizes of the five SNP associations are very small, behavioural genomic analyses using a 'g' SNP set illustrate how developmental, multivariate and GE questions can be addressed as more DNA associations are identified for complex traits such as 'g'. © 2005 Association for Child Psychology and Psychiatry.
Persistent Identifierhttp://hdl.handle.net/10722/175951
ISSN
2015 Impact Factor: 6.615
2015 SCImago Journal Rankings: 3.046
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHarlaar, Nen_US
dc.contributor.authorButcher, LMen_US
dc.contributor.authorMeaburn, Een_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorCraig, IWen_US
dc.contributor.authorPlomin, Ren_US
dc.date.accessioned2012-11-26T09:02:50Z-
dc.date.available2012-11-26T09:02:50Z-
dc.date.issued2005en_US
dc.identifier.citationJournal Of Child Psychology And Psychiatry And Allied Disciplines, 2005, v. 46 n. 10, p. 1097-1107en_US
dc.identifier.issn0021-9630en_US
dc.identifier.urihttp://hdl.handle.net/10722/175951-
dc.description.abstractBackground: Five DNA markers (single-nucleotide polymorphisms, SNPs) have recently been found to be associated with general cognitive ability ('g') in a sample of 7414 7-year-old twins. These children have also been studied at 2, 3, 4, and 7 years of age on measures of cognitive and language development and behaviour problems; family environment was also assessed. Methods: We used these data to conduct a behavioural genomic analysis of the five SNPs and a composite of them ('SNP set') that explored developmental, multivariate, and genotype-environment (GE) issues. Results: The 'g' SNP set identified at 7 years yielded significant associations with 'g' as early as 2 years. In multivariate analyses at 7 years, the 'g' SNP set was more strongly associated with verbal than nonverbal ability and with reading more than mathematics performance. GE correlations were found between the SNP set for 'g' at 7 years and preschool proximal measures of the family environment (chaos and discipline) rather than distal measures (maternal education and father's occupational class), suggesting evocative rather than passive GE correlation. Significant GE interactions were found for discipline, education and occupation in which the association between the SNP set and 'g' at 7 years is stronger in low-risk environments. Conclusions: Al though the effect sizes of the five SNP associations are very small, behavioural genomic analyses using a 'g' SNP set illustrate how developmental, multivariate and GE questions can be addressed as more DNA associations are identified for complex traits such as 'g'. © 2005 Association for Child Psychology and Psychiatry.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JCPPen_US
dc.relation.ispartofJournal of Child Psychology and Psychiatry and Allied Disciplinesen_US
dc.subject.meshChilden_US
dc.subject.meshChild Developmenten_US
dc.subject.meshCognitionen_US
dc.subject.meshEnvironmenten_US
dc.subject.meshEuropean Continental Ancestry Group - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetics, Behavioral - Methodsen_US
dc.subject.meshGreat Britainen_US
dc.subject.meshHumansen_US
dc.subject.meshIntelligence - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshMathematicsen_US
dc.subject.meshMultivariate Analysisen_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.subject.meshQuantitative Trait Locien_US
dc.subject.meshReadingen_US
dc.subject.meshRegression Analysisen_US
dc.titleA behavioural genomic analysis of DNA markers associated with general cognitive ability in 7-year-oldsen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1469-7610.2005.01515.xen_US
dc.identifier.pmid16178934-
dc.identifier.scopuseid_2-s2.0-33644670379en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33644670379&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume46en_US
dc.identifier.issue10en_US
dc.identifier.spage1097en_US
dc.identifier.epage1107en_US
dc.identifier.isiWOS:000232005900011-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridHarlaar, N=8964614900en_US
dc.identifier.scopusauthoridButcher, LM=8901700200en_US
dc.identifier.scopusauthoridMeaburn, E=7801402004en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridCraig, IW=7102548208en_US
dc.identifier.scopusauthoridPlomin, R=36050187200en_US
dc.identifier.citeulike329385-

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