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Article: Association analysis of dopamine D2-like receptor genes and methamphetamine abuse

TitleAssociation analysis of dopamine D2-like receptor genes and methamphetamine abuse
Authors
Issue Date2004
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.psychgenetics.com
Citation
Psychiatric Genetics, 2004, v. 14 n. 4, p. 223-226 How to Cite?
AbstractObjectives: Substance use disorders are familial, and genetic factors explain a substantial degree of their familial aggregation. This study employs an association approach to examine the genetic underpinning of methamphetamine (MAMP) use and MAMP-induced psychosis. Methods: A total of 416 MAMP abusers from a hospital and a detention center in Taipei were interviewed with the Diagnostic Interview for Genetic Study and the Family Interview for Genetic Study. Genetic polymorphisms of D2-like dopamine receptor genes, DRD2 Taql A, DRD3 Ser-9-Gly, and DRD4 exon III variable number of tandem repeats, were compared between: (a) MAMP users as a whole and 435 normal controls, and (b) those 154 individuals with MAMP-induced psychosis and the 252 MAMP users with no psychosis. Results: None of the three markers we studied were associated with predisposition to psychosis among the MAMP abusers. The MAMP abusers had a higher (P = 0.011) prevalence of the seven-repeat allele of DRD4 than normal controls. Conclusions: Chance fluctuations in the frequency of rare alleles and ascertainment differences in the case and control samples cannot be ruled out. Therefore, further studies of the seven-repeat allele in MAMP abusers and controls should be performed before an association can be established. © 2004 Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/175950
ISSN
2015 Impact Factor: 1.736
2015 SCImago Journal Rankings: 0.968
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, CKen_US
dc.contributor.authorHu, Xen_US
dc.contributor.authorLin, SKen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorLoh, EWen_US
dc.contributor.authorLi, Ten_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorBall, DMen_US
dc.date.accessioned2012-11-26T09:02:50Z-
dc.date.available2012-11-26T09:02:50Z-
dc.date.issued2004en_US
dc.identifier.citationPsychiatric Genetics, 2004, v. 14 n. 4, p. 223-226en_US
dc.identifier.issn0955-8829en_US
dc.identifier.urihttp://hdl.handle.net/10722/175950-
dc.description.abstractObjectives: Substance use disorders are familial, and genetic factors explain a substantial degree of their familial aggregation. This study employs an association approach to examine the genetic underpinning of methamphetamine (MAMP) use and MAMP-induced psychosis. Methods: A total of 416 MAMP abusers from a hospital and a detention center in Taipei were interviewed with the Diagnostic Interview for Genetic Study and the Family Interview for Genetic Study. Genetic polymorphisms of D2-like dopamine receptor genes, DRD2 Taql A, DRD3 Ser-9-Gly, and DRD4 exon III variable number of tandem repeats, were compared between: (a) MAMP users as a whole and 435 normal controls, and (b) those 154 individuals with MAMP-induced psychosis and the 252 MAMP users with no psychosis. Results: None of the three markers we studied were associated with predisposition to psychosis among the MAMP abusers. The MAMP abusers had a higher (P = 0.011) prevalence of the seven-repeat allele of DRD4 than normal controls. Conclusions: Chance fluctuations in the frequency of rare alleles and ascertainment differences in the case and control samples cannot be ruled out. Therefore, further studies of the seven-repeat allele in MAMP abusers and controls should be performed before an association can be established. © 2004 Lippincott Williams & Wilkins.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.psychgenetics.comen_US
dc.relation.ispartofPsychiatric Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMethamphetamineen_US
dc.subject.meshPsychotic Disorders - Etiology - Geneticsen_US
dc.subject.meshReceptors, Dopamine D2 - Geneticsen_US
dc.subject.meshSubstance-Related Disorders - Geneticsen_US
dc.titleAssociation analysis of dopamine D2-like receptor genes and methamphetamine abuseen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00041444-200412000-00011en_US
dc.identifier.pmid15564898-
dc.identifier.scopuseid_2-s2.0-3343027017en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3343027017&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume14en_US
dc.identifier.issue4en_US
dc.identifier.spage223en_US
dc.identifier.epage226en_US
dc.identifier.isiWOS:000226066500010-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChen, CK=7501961684en_US
dc.identifier.scopusauthoridHu, X=7404709241en_US
dc.identifier.scopusauthoridLin, SK=7407607751en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridLoh, EW=7102994165en_US
dc.identifier.scopusauthoridLi, T=36072008200en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridBall, DM=7202703810en_US

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