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Article: Whole genome linkage scan of recurrent depressive disorder from the depression network study

TitleWhole genome linkage scan of recurrent depressive disorder from the depression network study
Authors
Issue Date2005
PublisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/
Citation
Human Molecular Genetics, 2005, v. 14 n. 22, p. 3337-3345 How to Cite?
AbstractGenome-wide linkage analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive disorder (MDD). There was suggestive evidence for linkage on chromosome 1p36 where the LOD score for female-female pairs exceeded 3 (but reduced to 2.73 when corrected for multiple testing). The region includes a gene, MTHFR, that in previous studies has been associated with depressive symptoms. Two other regions, on chromosomes 12q23.3-q24.11 and 13q31.1-q31.3, showed evidence for linkage with a nominal P<0.01. The 12q peak overlaps with a region previously implicated by linkage studies of unipolar and bipolar disorders and contains a gene, DAO that has been associated with both bipolar disorder and schizophrenia. The 13q peak lies within a region previously linked strongly to panic disorder. A fourth modest peak with an LOD of greater than 1 on chromosome 15q lies within a region that showed genome-wide significant evidence of a recurrent depression locus in a previous sib-pair study. Both the 12q and the 15q findings remained significant at genome-wide level when the data from the present study and the previous reports were combined. © The Author 2005. Published by Oxford University Press. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/175945
ISSN
2015 Impact Factor: 5.985
2015 SCImago Journal Rankings: 4.288
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMcguffin, Pen_US
dc.contributor.authorKnight, Jen_US
dc.contributor.authorBreen, Gen_US
dc.contributor.authorBrewster, Sen_US
dc.contributor.authorBoyd, PRen_US
dc.contributor.authorCraddock, Nen_US
dc.contributor.authorGill, Men_US
dc.contributor.authorKorszun, Aen_US
dc.contributor.authorMaier, Wen_US
dc.contributor.authorMiddleton, Len_US
dc.contributor.authorMors, Oen_US
dc.contributor.authorOwen, MJen_US
dc.contributor.authorPerry, Jen_US
dc.contributor.authorPreisig, Men_US
dc.contributor.authorReich, Ten_US
dc.contributor.authorRice, Jen_US
dc.contributor.authorRietschel, Men_US
dc.contributor.authorJones, Len_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorFarmer, AEen_US
dc.date.accessioned2012-11-26T09:02:46Z-
dc.date.available2012-11-26T09:02:46Z-
dc.date.issued2005en_US
dc.identifier.citationHuman Molecular Genetics, 2005, v. 14 n. 22, p. 3337-3345en_US
dc.identifier.issn0964-6906en_US
dc.identifier.urihttp://hdl.handle.net/10722/175945-
dc.description.abstractGenome-wide linkage analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive disorder (MDD). There was suggestive evidence for linkage on chromosome 1p36 where the LOD score for female-female pairs exceeded 3 (but reduced to 2.73 when corrected for multiple testing). The region includes a gene, MTHFR, that in previous studies has been associated with depressive symptoms. Two other regions, on chromosomes 12q23.3-q24.11 and 13q31.1-q31.3, showed evidence for linkage with a nominal P<0.01. The 12q peak overlaps with a region previously implicated by linkage studies of unipolar and bipolar disorders and contains a gene, DAO that has been associated with both bipolar disorder and schizophrenia. The 13q peak lies within a region previously linked strongly to panic disorder. A fourth modest peak with an LOD of greater than 1 on chromosome 15q lies within a region that showed genome-wide significant evidence of a recurrent depression locus in a previous sib-pair study. Both the 12q and the 15q findings remained significant at genome-wide level when the data from the present study and the previous reports were combined. © The Author 2005. Published by Oxford University Press. All rights reserved.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://hmg.oxfordjournals.org/en_US
dc.relation.ispartofHuman Molecular Geneticsen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAllelesen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshDepressive Disorder - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenetic Linkageen_US
dc.subject.meshGenome, Humanen_US
dc.subject.meshHumansen_US
dc.subject.meshLod Scoreen_US
dc.subject.meshMaleen_US
dc.subject.meshRecurrenceen_US
dc.subject.meshTwin Studies As Topicen_US
dc.titleWhole genome linkage scan of recurrent depressive disorder from the depression network studyen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/hmg/ddi363en_US
dc.identifier.pmid16203746-
dc.identifier.scopuseid_2-s2.0-27944446099en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-27944446099&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume14en_US
dc.identifier.issue22en_US
dc.identifier.spage3337en_US
dc.identifier.epage3345en_US
dc.identifier.isiWOS:000233216600002-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridMcGuffin, P=22954119700en_US
dc.identifier.scopusauthoridKnight, J=13002769800en_US
dc.identifier.scopusauthoridBreen, G=15742166000en_US
dc.identifier.scopusauthoridBrewster, S=7006514148en_US
dc.identifier.scopusauthoridBoyd, PR=7103109018en_US
dc.identifier.scopusauthoridCraddock, N=35352014300en_US
dc.identifier.scopusauthoridGill, M=35228962600en_US
dc.identifier.scopusauthoridKorszun, A=6603686024en_US
dc.identifier.scopusauthoridMaier, W=36046783700en_US
dc.identifier.scopusauthoridMiddleton, L=7005171408en_US
dc.identifier.scopusauthoridMors, O=7004006411en_US
dc.identifier.scopusauthoridOwen, MJ=36044041500en_US
dc.identifier.scopusauthoridPerry, J=16307819400en_US
dc.identifier.scopusauthoridPreisig, M=6701501063en_US
dc.identifier.scopusauthoridReich, T=7103114523en_US
dc.identifier.scopusauthoridRice, J=35355165300en_US
dc.identifier.scopusauthoridRietschel, M=7006620620en_US
dc.identifier.scopusauthoridJones, L=34769954100en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridFarmer, AE=7102158824en_US

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