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Article: Association analysis of the RGS4 gene in Han Chinese and Scottish populations with schizophrenia

TitleAssociation analysis of the RGS4 gene in Han Chinese and Scottish populations with schizophrenia
Authors
Issue Date2005
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/G2B
Citation
Genes, Brain And Behavior, 2005, v. 4 n. 7, p. 444-448 How to Cite?
AbstractWe investigated the RGS4 as a susceptibility gene for schizophrenia in Chinese Han (184 trios and 138 sibling pairs, a total of 322 families) and Scottish (580 cases and 620 controls) populations using both a family trio and case-control design. Both the samples had statistical power greater than 70% to detect a heterozygote genotype relative risk of >1.2 for frequent RGS4-risk alleles. We genotyped four single nucleotide polymorphisms (SNPs) which have previously been associated with schizophrenia as either individually or part of haplotypes. Allele frequencies and linkage disequilibrium between the SNPs was similar in the two populations. In the Chinese sample, no individual SNPs or any of their haplotypes were associated with schizophrenia. In the Scottish population, one SNP (SNP7) was significantly over-represented in the cases compared with the controls (0.44 vs. 0.38; A allele; χ 2 7.08, P = 0.011 after correction for correlation between markers by permutation testing). One two-marker haplotype, composed of alleles T and A of SNP4 and SNP7, respectively, showed individual significance after correction by permutation testing (χ 2 6.8; P = 0.04). None of the full four-marker haplotypes showed association, including the G-G-G-G haplotype previously associated with schizophrenia in more than one sample and the A-T-A-A haplotype. Thus, our data do not directly replicate previous associations of RGS4, but association with SNP 7 in the Scottish population provides some support for a role in schizophrenia susceptibility. We cannot conclusively exclude RGS4, as associated haplotypes are likely to be surrogates for unknown causative alleles, whose relationship with overlying haplotypes may differ between the population groups. Differences in the association seen across the two populations could result from methodological factors such as diagnostic differences but most likely result from ethnic differences in haplotype structures within RGS4. Copyright © Blackwell Munksgaard 2005.
Persistent Identifierhttp://hdl.handle.net/10722/175941
ISSN
2015 Impact Factor: 3.275
2015 SCImago Journal Rankings: 1.947
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Fen_US
dc.contributor.authorSt Clair, Den_US
dc.contributor.authorLiu, Xen_US
dc.contributor.authorSun, Xen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorCrombie, Cen_US
dc.contributor.authorMa, Xen_US
dc.contributor.authorWang, Qen_US
dc.contributor.authorMeng, Hen_US
dc.contributor.authorDeng, Wen_US
dc.contributor.authorYates, Pen_US
dc.contributor.authorHu, Xen_US
dc.contributor.authorWalker, Nen_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorCollier, DAen_US
dc.contributor.authorLi, Ten_US
dc.date.accessioned2012-11-26T09:02:42Z-
dc.date.available2012-11-26T09:02:42Z-
dc.date.issued2005en_US
dc.identifier.citationGenes, Brain And Behavior, 2005, v. 4 n. 7, p. 444-448en_US
dc.identifier.issn1601-1848en_US
dc.identifier.urihttp://hdl.handle.net/10722/175941-
dc.description.abstractWe investigated the RGS4 as a susceptibility gene for schizophrenia in Chinese Han (184 trios and 138 sibling pairs, a total of 322 families) and Scottish (580 cases and 620 controls) populations using both a family trio and case-control design. Both the samples had statistical power greater than 70% to detect a heterozygote genotype relative risk of >1.2 for frequent RGS4-risk alleles. We genotyped four single nucleotide polymorphisms (SNPs) which have previously been associated with schizophrenia as either individually or part of haplotypes. Allele frequencies and linkage disequilibrium between the SNPs was similar in the two populations. In the Chinese sample, no individual SNPs or any of their haplotypes were associated with schizophrenia. In the Scottish population, one SNP (SNP7) was significantly over-represented in the cases compared with the controls (0.44 vs. 0.38; A allele; χ 2 7.08, P = 0.011 after correction for correlation between markers by permutation testing). One two-marker haplotype, composed of alleles T and A of SNP4 and SNP7, respectively, showed individual significance after correction by permutation testing (χ 2 6.8; P = 0.04). None of the full four-marker haplotypes showed association, including the G-G-G-G haplotype previously associated with schizophrenia in more than one sample and the A-T-A-A haplotype. Thus, our data do not directly replicate previous associations of RGS4, but association with SNP 7 in the Scottish population provides some support for a role in schizophrenia susceptibility. We cannot conclusively exclude RGS4, as associated haplotypes are likely to be surrogates for unknown causative alleles, whose relationship with overlying haplotypes may differ between the population groups. Differences in the association seen across the two populations could result from methodological factors such as diagnostic differences but most likely result from ethnic differences in haplotype structures within RGS4. Copyright © Blackwell Munksgaard 2005.en_US
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/G2Ben_US
dc.relation.ispartofGenes, Brain and Behavioren_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChina - Epidemiologyen_US
dc.subject.meshGenetic Predisposition To Disease - Geneticsen_US
dc.subject.meshHaplotypes - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshLinkage Disequilibriumen_US
dc.subject.meshPedigreeen_US
dc.subject.meshPolymorphism, Single Nucleotide - Geneticsen_US
dc.subject.meshRgs Proteins - Geneticsen_US
dc.subject.meshSchizophrenia - Ethnology - Geneticsen_US
dc.subject.meshScotland - Epidemiologyen_US
dc.titleAssociation analysis of the RGS4 gene in Han Chinese and Scottish populations with schizophreniaen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1601-183X.2005.00167.xen_US
dc.identifier.pmid16176390-
dc.identifier.scopuseid_2-s2.0-26444531847en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-26444531847&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume4en_US
dc.identifier.issue7en_US
dc.identifier.spage444en_US
dc.identifier.epage448en_US
dc.identifier.isiWOS:000232586300005-
dc.publisher.placeDenmarken_US
dc.identifier.scopusauthoridZhang, F=24465951900en_US
dc.identifier.scopusauthoridSt Clair, D=35354078200en_US
dc.identifier.scopusauthoridLiu, X=7409286408en_US
dc.identifier.scopusauthoridSun, X=7405624871en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridCrombie, C=12240136900en_US
dc.identifier.scopusauthoridMa, X=35354066000en_US
dc.identifier.scopusauthoridWang, Q=7406916913en_US
dc.identifier.scopusauthoridMeng, H=9133658800en_US
dc.identifier.scopusauthoridDeng, W=7202222559en_US
dc.identifier.scopusauthoridYates, P=8921964400en_US
dc.identifier.scopusauthoridHu, X=7404709241en_US
dc.identifier.scopusauthoridWalker, N=7201514664en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridCollier, DA=26642980600en_US
dc.identifier.scopusauthoridLi, T=36072008200en_US
dc.identifier.citeulike328611-

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