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Article: Is the P300 wave an endophenotype for schizophrenia? A meta-analysis and a family study

TitleIs the P300 wave an endophenotype for schizophrenia? A meta-analysis and a family study
Authors
Issue Date2005
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
Citation
Neuroimage, 2005, v. 27 n. 4, p. 960-968 How to Cite?
AbstractWe assessed the usefulness of the P300 wave as endophenotype for schizophrenia by means of a meta-analysis of the literature as well as our own family study. Method: Meta-analysis: We conducted a systematic search for articles published between 1983 and 2003 that reported P300 measures in non-psychotic relatives of schizophrenic patients and in healthy controls. Meta-regression analyses were performed using a random effects procedure. The pooled standardized effect size (PSES) was calculated as the difference between the means of the two groups divided by the common standard deviation. Local study: We examined the P300 wave with a standard two-tone oddball paradigm in 30 patients with schizophrenia, 40 non-psychotic relatives, and 40 controls using linear mixed models. Results: Meta-analysis: We pooled 472 relatives and 513 controls. The P300 amplitude was significantly reduced in relatives (PSES = 0.61; 95% CI: 0.30 to 0.91; P < 0.001). The P300 latency was significantly delayed in relatives (PSES of -0.50; 95% CI: -0.88 to -0.13; P = 0.009]. Local study: The patients showed a trend for amplitude reductions (P = 0.06) and significant latency delays (P < 0.01). The relatives displayed normal amplitude but had significant latency delays (P = 0.01). The P300 amplitude and especially the P300 latency are promising alternative phenotypes for genetic research into schizophrenia. © 2005 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/175940
ISSN
2015 Impact Factor: 5.463
2015 SCImago Journal Rankings: 4.464
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBramon, Een_US
dc.contributor.authorMcdonald, Cen_US
dc.contributor.authorCroft, RJen_US
dc.contributor.authorLandau, Sen_US
dc.contributor.authorFilbey, Fen_US
dc.contributor.authorGruzelier, JHen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorFrangou, Sen_US
dc.contributor.authorMurray, RMen_US
dc.date.accessioned2012-11-26T09:02:41Z-
dc.date.available2012-11-26T09:02:41Z-
dc.date.issued2005en_US
dc.identifier.citationNeuroimage, 2005, v. 27 n. 4, p. 960-968en_US
dc.identifier.issn1053-8119en_US
dc.identifier.urihttp://hdl.handle.net/10722/175940-
dc.description.abstractWe assessed the usefulness of the P300 wave as endophenotype for schizophrenia by means of a meta-analysis of the literature as well as our own family study. Method: Meta-analysis: We conducted a systematic search for articles published between 1983 and 2003 that reported P300 measures in non-psychotic relatives of schizophrenic patients and in healthy controls. Meta-regression analyses were performed using a random effects procedure. The pooled standardized effect size (PSES) was calculated as the difference between the means of the two groups divided by the common standard deviation. Local study: We examined the P300 wave with a standard two-tone oddball paradigm in 30 patients with schizophrenia, 40 non-psychotic relatives, and 40 controls using linear mixed models. Results: Meta-analysis: We pooled 472 relatives and 513 controls. The P300 amplitude was significantly reduced in relatives (PSES = 0.61; 95% CI: 0.30 to 0.91; P < 0.001). The P300 latency was significantly delayed in relatives (PSES of -0.50; 95% CI: -0.88 to -0.13; P = 0.009]. Local study: The patients showed a trend for amplitude reductions (P = 0.06) and significant latency delays (P < 0.01). The relatives displayed normal amplitude but had significant latency delays (P = 0.01). The P300 amplitude and especially the P300 latency are promising alternative phenotypes for genetic research into schizophrenia. © 2005 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimgen_US
dc.relation.ispartofNeuroImageen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshEvent-Related Potentials, P300 - Physiologyen_US
dc.subject.meshFamilyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLinear Modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPsychiatric Status Rating Scalesen_US
dc.subject.meshSchizophrenia - Genetics - Physiopathologyen_US
dc.titleIs the P300 wave an endophenotype for schizophrenia? A meta-analysis and a family studyen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.neuroimage.2005.05.022en_US
dc.identifier.pmid16009570-
dc.identifier.scopuseid_2-s2.0-24944542218en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-24944542218&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume27en_US
dc.identifier.issue4en_US
dc.identifier.spage960en_US
dc.identifier.epage968en_US
dc.identifier.isiWOS:000232141200024-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridBramon, E=8089378900en_US
dc.identifier.scopusauthoridMcDonald, C=8749594800en_US
dc.identifier.scopusauthoridCroft, RJ=7004945198en_US
dc.identifier.scopusauthoridLandau, S=7101776972en_US
dc.identifier.scopusauthoridFilbey, F=13606061900en_US
dc.identifier.scopusauthoridGruzelier, JH=7004536505en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridFrangou, S=7004549374en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.citeulike2302104-

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