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Article: Genesis: Creating a composite index of the vulnerability to anxiety and depression in a community-based sample of siblings

TitleGenesis: Creating a composite index of the vulnerability to anxiety and depression in a community-based sample of siblings
Authors
Issue Date2000
Citation
Twin Research, 2000, v. 3 n. 4, p. 316-322 How to Cite?
AbstractThere is considerable evidence for a unitary and dimensional view of the genetic vulnerability to symptoms of anxiety and depression. The GENESiS (Genetic Environmental-Nature of Emotional States in Siblings) Study aims to use a multivariate approach to detect genetic loci that contribute to individual differences in this vulnerability dimension. The study used the UK General Practice Research Framework to generate a community-based sample of siblings. Questionnaire measures of anxiety/depression included the short form of the neuroticism scale from the revised Eysenck Personality Questionnaire (EPQ-N), the General Health Questionnaire (GHQ-12), and the anxious arousal and high positive affect subscales from the Mood and Anxiety Symptoms Questionnaire (MASQ-AA and MASQ-HPA). Genetic model-fitting of 2658 unselected sibships provided evidence for a single common genetic (familial) factor that accounted for a substantial proportion of the genetic variances and covariances of these four measures. Using the parameter estimates of this model, we constructed a composite index of this common genetic factor. This index, which has a sib correlation of 0.22, will be used as a quantitative phenotype in the molecular genetic phase of GENESiS.
Persistent Identifierhttp://hdl.handle.net/10722/175921
ISSN
2006 Impact Factor: 1.757
References

 

DC FieldValueLanguage
dc.contributor.authorSham, PCen_US
dc.contributor.authorSterne, Aen_US
dc.contributor.authorPurcell, Sen_US
dc.contributor.authorCherny, Sen_US
dc.contributor.authorWebters, Men_US
dc.contributor.authorRijsdijk, Fen_US
dc.contributor.authorAsherson, Pen_US
dc.contributor.authorBall, Den_US
dc.contributor.authorCraig, Ien_US
dc.contributor.authorEley, Ten_US
dc.contributor.authorGoldberg, Den_US
dc.contributor.authorGray, Jen_US
dc.contributor.authorMann, Aen_US
dc.contributor.authorOwen, Men_US
dc.contributor.authorPlomin, Ren_US
dc.date.accessioned2012-11-26T09:02:30Z-
dc.date.available2012-11-26T09:02:30Z-
dc.date.issued2000en_US
dc.identifier.citationTwin Research, 2000, v. 3 n. 4, p. 316-322en_US
dc.identifier.issn1369-0523en_US
dc.identifier.urihttp://hdl.handle.net/10722/175921-
dc.description.abstractThere is considerable evidence for a unitary and dimensional view of the genetic vulnerability to symptoms of anxiety and depression. The GENESiS (Genetic Environmental-Nature of Emotional States in Siblings) Study aims to use a multivariate approach to detect genetic loci that contribute to individual differences in this vulnerability dimension. The study used the UK General Practice Research Framework to generate a community-based sample of siblings. Questionnaire measures of anxiety/depression included the short form of the neuroticism scale from the revised Eysenck Personality Questionnaire (EPQ-N), the General Health Questionnaire (GHQ-12), and the anxious arousal and high positive affect subscales from the Mood and Anxiety Symptoms Questionnaire (MASQ-AA and MASQ-HPA). Genetic model-fitting of 2658 unselected sibships provided evidence for a single common genetic (familial) factor that accounted for a substantial proportion of the genetic variances and covariances of these four measures. Using the parameter estimates of this model, we constructed a composite index of this common genetic factor. This index, which has a sib correlation of 0.22, will be used as a quantitative phenotype in the molecular genetic phase of GENESiS.en_US
dc.languageengen_US
dc.relation.ispartofTwin Researchen_US
dc.subject.meshAdulten_US
dc.subject.meshAnxiety - Diagnosis - Epidemiology - Genetics - Psychologyen_US
dc.subject.meshDatabases, Factualen_US
dc.subject.meshDepression - Diagnosis - Epidemiology - Genetics - Psychologyen_US
dc.subject.meshEnvironmenten_US
dc.subject.meshFactor Analysis, Statisticalen_US
dc.subject.meshFamilyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshGreat Britain - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshModels, Geneticen_US
dc.subject.meshMultivariate Analysisen_US
dc.subject.meshPersonality - Geneticsen_US
dc.subject.meshPersonality Inventoryen_US
dc.subject.meshPopulation Surveillanceen_US
dc.subject.meshPsychiatric Status Rating Scalesen_US
dc.subject.meshQuantitative Trait, Heritableen_US
dc.subject.meshQuestionnairesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSampling Studiesen_US
dc.subject.meshSeverity Of Illness Indexen_US
dc.subject.meshSocioeconomic Factorsen_US
dc.titleGenesis: Creating a composite index of the vulnerability to anxiety and depression in a community-based sample of siblingsen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.emailCherny, S: cherny@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.identifier.authorityCherny, S=rp00232en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1375/136905200320565292en_US
dc.identifier.pmid11463153-
dc.identifier.scopuseid_2-s2.0-17744380419en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-17744380419&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume3en_US
dc.identifier.issue4en_US
dc.identifier.spage316en_US
dc.identifier.epage322en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridSterne, A=6603417496en_US
dc.identifier.scopusauthoridPurcell, S=7005489464en_US
dc.identifier.scopusauthoridCherny, S=7004670001en_US
dc.identifier.scopusauthoridWebters, M=6505653448en_US
dc.identifier.scopusauthoridRijsdijk, F=6701830835en_US
dc.identifier.scopusauthoridAsherson, P=35402700900en_US
dc.identifier.scopusauthoridBall, D=7202703810en_US
dc.identifier.scopusauthoridCraig, I=7102548208en_US
dc.identifier.scopusauthoridEley, T=7003787769en_US
dc.identifier.scopusauthoridGoldberg, D=7401442597en_US
dc.identifier.scopusauthoridGray, J=18436666600en_US
dc.identifier.scopusauthoridMann, A=7201627833en_US
dc.identifier.scopusauthoridOwen, M=36044041500en_US
dc.identifier.scopusauthoridPlomin, R=36050187200en_US

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