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Article: Association analysis of monoamine genes with measures of depression and anxiety in a selected community sample of siblings

TitleAssociation analysis of monoamine genes with measures of depression and anxiety in a selected community sample of siblings
Authors
Issue Date2005
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 2005, v. 135 B n. 1, p. 33-37 How to Cite?
AbstractEvidence indicates the genetic susceptibility to depression and anxiety is both overlapping and dimensional. In the current study, a quantitative phenotype had been created from several depression and anxiety-related measures in order to index this common genetic susceptibility (G). This has been studied in 119 sibships comprising 312 individuals, selected for extreme scores on G, from a community-based sample of 34,371 individuals. In a pathway based candidate gene study, we examined five microsatellite markers located within or nearby to five serotonin system genes (5HT2C, 5HT1D, SHT1B, TPH1, and MAOB). Statistical analysis, carried out using QTDT, gave a significant association with a microsatellite downstream of TPH1. Further analysis included a life-events composite as a co-variable, this lead to a stronger association of TPH1. To our knowledge, this is the first study to report an association of the 3′ end of TPH1 with continuous measures of depression and anxiety. © 2005 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/175920
ISSN
2015 Impact Factor: 3.391
2015 SCImago Journal Rankings: 1.771
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNash, MWen_US
dc.contributor.authorSugden, Ken_US
dc.contributor.authorHuezoDiaz, Pen_US
dc.contributor.authorWilliamson, Ren_US
dc.contributor.authorSterne, Aen_US
dc.contributor.authorPurcell, Sen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorCraig, IWen_US
dc.date.accessioned2012-11-26T09:02:29Z-
dc.date.available2012-11-26T09:02:29Z-
dc.date.issued2005en_US
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 2005, v. 135 B n. 1, p. 33-37en_US
dc.identifier.issn1552-4841en_US
dc.identifier.urihttp://hdl.handle.net/10722/175920-
dc.description.abstractEvidence indicates the genetic susceptibility to depression and anxiety is both overlapping and dimensional. In the current study, a quantitative phenotype had been created from several depression and anxiety-related measures in order to index this common genetic susceptibility (G). This has been studied in 119 sibships comprising 312 individuals, selected for extreme scores on G, from a community-based sample of 34,371 individuals. In a pathway based candidate gene study, we examined five microsatellite markers located within or nearby to five serotonin system genes (5HT2C, 5HT1D, SHT1B, TPH1, and MAOB). Statistical analysis, carried out using QTDT, gave a significant association with a microsatellite downstream of TPH1. Further analysis included a life-events composite as a co-variable, this lead to a stronger association of TPH1. To our knowledge, this is the first study to report an association of the 3′ end of TPH1 with continuous measures of depression and anxiety. © 2005 Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/en_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_US
dc.subject.meshAllelesen_US
dc.subject.meshAnxiety Disorders - Geneticsen_US
dc.subject.meshDepressive Disorder - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenetic Predisposition To Disease - Geneticsen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrosatellite Repeats - Geneticsen_US
dc.subject.meshMonoamine Oxidase - Geneticsen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshQuestionnairesen_US
dc.subject.meshReceptor, Serotonin, 5-Ht1b - Geneticsen_US
dc.subject.meshReceptor, Serotonin, 5-Ht1d - Geneticsen_US
dc.subject.meshReceptor, Serotonin, 5-Ht2c - Geneticsen_US
dc.subject.meshSiblingsen_US
dc.subject.meshTryptophan Hydroxylase - Geneticsen_US
dc.titleAssociation analysis of monoamine genes with measures of depression and anxiety in a selected community sample of siblingsen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ajmg.b.30063en_US
dc.identifier.pmid15729745-
dc.identifier.scopuseid_2-s2.0-17744375972en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-17744375972&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume135 Ben_US
dc.identifier.issue1en_US
dc.identifier.spage33en_US
dc.identifier.epage37en_US
dc.identifier.isiWOS:000228759500007-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridNash, MW=8771626900en_US
dc.identifier.scopusauthoridSugden, K=36765392300en_US
dc.identifier.scopusauthoridHuezoDiaz, P=6506170044en_US
dc.identifier.scopusauthoridWilliamson, R=7401944359en_US
dc.identifier.scopusauthoridSterne, A=6603417496en_US
dc.identifier.scopusauthoridPurcell, S=7005489464en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridCraig, IW=7102548208en_US

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