File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Mismatch negativity in schizophrenia: A family study

TitleMismatch negativity in schizophrenia: A family study
Authors
Issue Date2004
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2004, v. 67 n. 1, p. 1-10 How to Cite?
AbstractBackground: Mismatch negativity (MMN) is a measure of cortical activity that occurs in response to a change in auditory stimuli. We investigated whether MMN is a potential marker of genetic vulnerability to schizophrenia by comparing MMN in a group of patients with schizophrenia, their unaffected relatives, and controls. Method: There are 25 schizophrenic patients, 37 of their unaffected first-degree relatives, and 20 unrelated controls that performed the MMN task. Linear regression with robust standard errors, and accounting for correlations within families, was employed to test for differences in MMN amplitude between the groups. Results: Patients had significantly smaller MMN amplitudes compared to both their unaffected relatives and controls at FZ (P<0.01) and at F3 (P=0.01), whereas relatives and controls did not differ at FZ or at F3. No differences were found between any of the groups at F4. Furthermore, we found no strong evidence that the MMN amplitude is a familial trait. Conclusions: Our results confirm that the MMN amplitude is reduced in schizophrenia. However, the MMN does not show a significant familial influence and is normal among the unaffected relatives. We conclude that while the MMN is abnormal in patients with schizophrenia, it is a weak or unreliable marker of vulnerability when applied to subclinical populations, and therefore is unlikely to be an endophenotype for the disorder. © 2003 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/175917
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBramon, Een_US
dc.contributor.authorCroft, RJen_US
dc.contributor.authorMcdonald, Cen_US
dc.contributor.authorVirdi, GKen_US
dc.contributor.authorGruzelier, JGen_US
dc.contributor.authorBaldeweg, Ten_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorFrangou, Sen_US
dc.contributor.authorMurray, RMen_US
dc.date.accessioned2012-11-26T09:02:28Z-
dc.date.available2012-11-26T09:02:28Z-
dc.date.issued2004en_US
dc.identifier.citationSchizophrenia Research, 2004, v. 67 n. 1, p. 1-10en_US
dc.identifier.issn0920-9964en_US
dc.identifier.urihttp://hdl.handle.net/10722/175917-
dc.description.abstractBackground: Mismatch negativity (MMN) is a measure of cortical activity that occurs in response to a change in auditory stimuli. We investigated whether MMN is a potential marker of genetic vulnerability to schizophrenia by comparing MMN in a group of patients with schizophrenia, their unaffected relatives, and controls. Method: There are 25 schizophrenic patients, 37 of their unaffected first-degree relatives, and 20 unrelated controls that performed the MMN task. Linear regression with robust standard errors, and accounting for correlations within families, was employed to test for differences in MMN amplitude between the groups. Results: Patients had significantly smaller MMN amplitudes compared to both their unaffected relatives and controls at FZ (P<0.01) and at F3 (P=0.01), whereas relatives and controls did not differ at FZ or at F3. No differences were found between any of the groups at F4. Furthermore, we found no strong evidence that the MMN amplitude is a familial trait. Conclusions: Our results confirm that the MMN amplitude is reduced in schizophrenia. However, the MMN does not show a significant familial influence and is normal among the unaffected relatives. We conclude that while the MMN is abnormal in patients with schizophrenia, it is a weak or unreliable marker of vulnerability when applied to subclinical populations, and therefore is unlikely to be an endophenotype for the disorder. © 2003 Elsevier B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_US
dc.relation.ispartofSchizophrenia Researchen_US
dc.subject.meshAcoustic Stimulationen_US
dc.subject.meshAdulten_US
dc.subject.meshArousal - Physiologyen_US
dc.subject.meshBrain - Physiopathologyen_US
dc.subject.meshDiagnostic And Statistical Manual Of Mental Disordersen_US
dc.subject.meshElectroencephalographyen_US
dc.subject.meshElectrooculographyen_US
dc.subject.meshEye Movements - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFrontal Lobe - Physiopathologyen_US
dc.subject.meshFunctional Laterality - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLinear Modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshSchizophrenia - Diagnosis - Genetics - Physiopathologyen_US
dc.subject.meshSchizophrenic Psychologyen_US
dc.titleMismatch negativity in schizophrenia: A family studyen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0920-9964(03)00132-4en_US
dc.identifier.pmid14741319-
dc.identifier.scopuseid_2-s2.0-1642564726en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1642564726&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume67en_US
dc.identifier.issue1en_US
dc.identifier.spage1en_US
dc.identifier.epage10en_US
dc.identifier.isiWOS:000188738800001-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridBramon, E=8089378900en_US
dc.identifier.scopusauthoridCroft, RJ=7004945198en_US
dc.identifier.scopusauthoridMcDonald, C=8749594800en_US
dc.identifier.scopusauthoridVirdi, GK=6603717279en_US
dc.identifier.scopusauthoridGruzelier, JG=35612961800en_US
dc.identifier.scopusauthoridBaldeweg, T=7003274699en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridFrangou, S=7004549374en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats