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Article: The serotonin transporter is a potential susceptibility factor for bipolar affective disorder

TitleThe serotonin transporter is a potential susceptibility factor for bipolar affective disorder
Authors
Issue Date1996
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.com
Citation
Neuroreport, 1996, v. 7 n. 10, p. 1675-1679 How to Cite?
AbstractThe serotonin transporter is a strong candidate for aetiological involvement in affective disorders and psychosis. We analysed a VNTR in intron 2 of the human serotonin transporter gene (hSERT) for allelic association with bipolar affective disorder, unipolar depression and schizophrenia. An increased frequency of allele 12 of the VNTR was observed in subjects with bipolar affective disorder (n = 191; χ 2 p = 0.00048 by allele) but not unipolar depression (n = 86; χ 2 p = 0.18, ns) or schizophrenia (n = 129; χ 2 P = 0.08, ns), although a trend towards an excess of allele 12 was observed for the latter. There was also a significant difference in the frequency of allele 12 between bipolar affective disorder and unipolar depression (p = 0.0087). The relative risk for bipolar affective disorder with respect to allele 12 was 1.84 (95% CI 0.97-3.56) for heterozygotes, and 3.10 (95% CI 1.60-6.07) for homozygotes, with evidence for a gene-dosage effect. Because allele 12 is common in the population, the attributable risk is 50.8% (95% CI 14.5%-73.3%). We hypothesize that either the VNTR affects regulation of expression of hSERT at the transcriptional level or it is in linkage disequilibrium with another functional polymorphism in the gene, and this results in an increased risk for the development of bipolar affective disorder.
Persistent Identifierhttp://hdl.handle.net/10722/175916
ISSN
2015 Impact Factor: 1.343
2015 SCImago Journal Rankings: 0.783
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCollier, DAen_US
dc.contributor.authorArranz, MJen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorBattersby, Sen_US
dc.contributor.authorVallada, Hen_US
dc.contributor.authorGill, Pen_US
dc.contributor.authorAitchison, KJen_US
dc.contributor.authorSodhi, Men_US
dc.contributor.authorLi, Ten_US
dc.contributor.authorRoberts, GWen_US
dc.contributor.authorSmith, Ben_US
dc.contributor.authorMorton, Jen_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorSmith, Den_US
dc.contributor.authorKirov, Gen_US
dc.date.accessioned2012-11-26T09:02:27Z-
dc.date.available2012-11-26T09:02:27Z-
dc.date.issued1996en_US
dc.identifier.citationNeuroreport, 1996, v. 7 n. 10, p. 1675-1679en_US
dc.identifier.issn0959-4965en_US
dc.identifier.urihttp://hdl.handle.net/10722/175916-
dc.description.abstractThe serotonin transporter is a strong candidate for aetiological involvement in affective disorders and psychosis. We analysed a VNTR in intron 2 of the human serotonin transporter gene (hSERT) for allelic association with bipolar affective disorder, unipolar depression and schizophrenia. An increased frequency of allele 12 of the VNTR was observed in subjects with bipolar affective disorder (n = 191; χ 2 p = 0.00048 by allele) but not unipolar depression (n = 86; χ 2 p = 0.18, ns) or schizophrenia (n = 129; χ 2 P = 0.08, ns), although a trend towards an excess of allele 12 was observed for the latter. There was also a significant difference in the frequency of allele 12 between bipolar affective disorder and unipolar depression (p = 0.0087). The relative risk for bipolar affective disorder with respect to allele 12 was 1.84 (95% CI 0.97-3.56) for heterozygotes, and 3.10 (95% CI 1.60-6.07) for homozygotes, with evidence for a gene-dosage effect. Because allele 12 is common in the population, the attributable risk is 50.8% (95% CI 14.5%-73.3%). We hypothesize that either the VNTR affects regulation of expression of hSERT at the transcriptional level or it is in linkage disequilibrium with another functional polymorphism in the gene, and this results in an increased risk for the development of bipolar affective disorder.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.comen_US
dc.relation.ispartofNeuroReporten_US
dc.subject.meshAllelesen_US
dc.subject.meshBipolar Disorder - Geneticsen_US
dc.subject.meshCarrier Proteins - Geneticsen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshMembrane Glycoproteins - Geneticsen_US
dc.subject.meshMembrane Transport Proteinsen_US
dc.subject.meshMinisatellite Repeatsen_US
dc.subject.meshNerve Tissue Proteinsen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSchizophrenia - Geneticsen_US
dc.subject.meshSerotonin Plasma Membrane Transport Proteinsen_US
dc.titleThe serotonin transporter is a potential susceptibility factor for bipolar affective disorderen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00001756-199607080-00030-
dc.identifier.pmid8904780-
dc.identifier.scopuseid_2-s2.0-1642469628en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1642469628&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume7en_US
dc.identifier.issue10en_US
dc.identifier.spage1675en_US
dc.identifier.epage1679en_US
dc.identifier.isiWOS:A1996VM53100030-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCollier, DA=26642980600en_US
dc.identifier.scopusauthoridArranz, MJ=7006010757en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridBattersby, S=7006017639en_US
dc.identifier.scopusauthoridVallada, H=7003742958en_US
dc.identifier.scopusauthoridGill, P=7202766697en_US
dc.identifier.scopusauthoridAitchison, KJ=7003415672en_US
dc.identifier.scopusauthoridSodhi, M=7004463507en_US
dc.identifier.scopusauthoridLi, T=36072008200en_US
dc.identifier.scopusauthoridRoberts, GW=7403400681en_US
dc.identifier.scopusauthoridSmith, B=35413321700en_US
dc.identifier.scopusauthoridMorton, J=8410455200en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridSmith, D=7410356881en_US
dc.identifier.scopusauthoridKirov, G=26643478800en_US

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