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Article: The serotonin transporter gene as a QTL for ADHB

TitleThe serotonin transporter gene as a QTL for ADHB
Authors
Issue Date2005
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 2005, v. 134 B n. 1, p. 42-47 How to Cite?
AbstractMolecular studies of attention deficit hyperactivity disorder (ADHDD) have identified susceptibility genes for the categorically diagnosed disorder using operational diagnostic criteria. Here, we take a QTL approach to mapping genes for ADHD using a composite continuous index of ADHD behavior in a large epidemiological sample. Previous studies of clinical ADHD suggest that two functional polymorphisms in the serotonin transporter gene (SLC6A4), one in the 5′-regulatory region of the gene (5-HTTLPR) and the other a VNTR (5-HTTVNTR) in the second intron, as well as a single nucleotide polymorphism in the 3′-untranslated region (3′-UTR SNP), may be associated with the disorder. Here, we investigate these polymorphisms as well as an additional ten SNPs spread across the gene. We found significant association with the long (L) allele of the 5-HTTLPR; P = 0.019, but neither the 5-HTTVNTR nor the 3′-UTR SNP were significantly associated. Significant associations (P < 0.05) were found for a further 5 the 10 other markers tested. We found evidence for two haplotype blocks spanning the region. We found strong evidence for association with the first haplotype block (comprised of four markers), with the significance of a combined primary and secondary test of association reaching an empirical P value = 0.0054 for the global test and an empirical P value = 0.00081 for the largest local test. Thus, we show here that SLC6A4, which has a major influence on brain serotonin availability, may be a QTL for ADHD. © 2005 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/175913
ISSN
2015 Impact Factor: 3.391
2015 SCImago Journal Rankings: 1.771
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCurran, Sen_US
dc.contributor.authorPurcell, Sen_US
dc.contributor.authorCraig, Ien_US
dc.contributor.authorAsherson, Pen_US
dc.contributor.authorSham, Pen_US
dc.date.accessioned2012-11-26T09:02:25Z-
dc.date.available2012-11-26T09:02:25Z-
dc.date.issued2005en_US
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 2005, v. 134 B n. 1, p. 42-47en_US
dc.identifier.issn1552-4841en_US
dc.identifier.urihttp://hdl.handle.net/10722/175913-
dc.description.abstractMolecular studies of attention deficit hyperactivity disorder (ADHDD) have identified susceptibility genes for the categorically diagnosed disorder using operational diagnostic criteria. Here, we take a QTL approach to mapping genes for ADHD using a composite continuous index of ADHD behavior in a large epidemiological sample. Previous studies of clinical ADHD suggest that two functional polymorphisms in the serotonin transporter gene (SLC6A4), one in the 5′-regulatory region of the gene (5-HTTLPR) and the other a VNTR (5-HTTVNTR) in the second intron, as well as a single nucleotide polymorphism in the 3′-untranslated region (3′-UTR SNP), may be associated with the disorder. Here, we investigate these polymorphisms as well as an additional ten SNPs spread across the gene. We found significant association with the long (L) allele of the 5-HTTLPR; P = 0.019, but neither the 5-HTTVNTR nor the 3′-UTR SNP were significantly associated. Significant associations (P < 0.05) were found for a further 5 the 10 other markers tested. We found evidence for two haplotype blocks spanning the region. We found strong evidence for association with the first haplotype block (comprised of four markers), with the significance of a combined primary and secondary test of association reaching an empirical P value = 0.0054 for the global test and an empirical P value = 0.00081 for the largest local test. Thus, we show here that SLC6A4, which has a major influence on brain serotonin availability, may be a QTL for ADHD. © 2005 Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/en_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAllelesen_US
dc.subject.meshAttention Deficit Disorder With Hyperactivity - Geneticsen_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHaplotypesen_US
dc.subject.meshHumansen_US
dc.subject.meshIntrons - Geneticsen_US
dc.subject.meshLinkage Disequilibriumen_US
dc.subject.meshMembrane Glycoproteins - Geneticsen_US
dc.subject.meshMembrane Transport Proteins - Geneticsen_US
dc.subject.meshMinisatellite Repeats - Geneticsen_US
dc.subject.meshNerve Tissue Proteins - Geneticsen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.subject.meshPromoter Regions, Genetic - Geneticsen_US
dc.subject.meshQuantitative Trait Loci - Geneticsen_US
dc.subject.meshSequence Deletionen_US
dc.subject.meshSerotonin Plasma Membrane Transport Proteinsen_US
dc.titleThe serotonin transporter gene as a QTL for ADHBen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ajmg.b.30118en_US
dc.identifier.pmid15719397-
dc.identifier.scopuseid_2-s2.0-15744399333en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-15744399333&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume134 Ben_US
dc.identifier.issue1en_US
dc.identifier.spage42en_US
dc.identifier.epage47en_US
dc.identifier.isiWOS:000227927100010-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCurran, S=7103220956en_US
dc.identifier.scopusauthoridPurcell, S=7005489464en_US
dc.identifier.scopusauthoridCraig, I=7102548208en_US
dc.identifier.scopusauthoridAsherson, P=35402700900en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.citeulike4868357-

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