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Article: Allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimer's disease

TitleAllelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimer's disease
Authors
Issue Date1997
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.com
Citation
Neuroreport, 1997, v. 8 n. 3, p. 683-686 How to Cite?
AbstractWe examined a deletion/insertion promoter polymorphism of the serotonin transporter gene, which confers an ~ 40% reduction in ssion of the protein, in 196 subjects with late onset Alzheimer's disease (AD) and 271 controls. The frequency of the 484 bp low activity allele was elevated in the subjects with AD (p = 0.004), and an excess of the low activity genotype (30%) was also found in comparison with the controls (20%) (χ2 = 7.16; p = 0.03). This association was unrelated to the age of the subjects or controls, or to ε4 alleles of the ApoE gene. The odds ratio for the effect of the homozygous low activity genotype was 1.7 (95% CI 1.08-2.67), with a population attributable risk of 33% (95% CI 5-54%). These findings indicate that the low activity allele of the serotonin transporter is a risk factor for late onset AD.
Persistent Identifierhttp://hdl.handle.net/10722/175910
ISSN
2015 Impact Factor: 1.343
2015 SCImago Journal Rankings: 0.783
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Ten_US
dc.contributor.authorHolmes, Cen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorVallada, Hen_US
dc.contributor.authorBirkett, Jen_US
dc.contributor.authorKirov, Gen_US
dc.contributor.authorLesch, KPen_US
dc.contributor.authorPowell, Jen_US
dc.contributor.authorLovestone, Sen_US
dc.contributor.authorCollier, Den_US
dc.date.accessioned2012-11-26T09:02:24Z-
dc.date.available2012-11-26T09:02:24Z-
dc.date.issued1997en_US
dc.identifier.citationNeuroreport, 1997, v. 8 n. 3, p. 683-686en_US
dc.identifier.issn0959-4965en_US
dc.identifier.urihttp://hdl.handle.net/10722/175910-
dc.description.abstractWe examined a deletion/insertion promoter polymorphism of the serotonin transporter gene, which confers an ~ 40% reduction in ssion of the protein, in 196 subjects with late onset Alzheimer's disease (AD) and 271 controls. The frequency of the 484 bp low activity allele was elevated in the subjects with AD (p = 0.004), and an excess of the low activity genotype (30%) was also found in comparison with the controls (20%) (χ2 = 7.16; p = 0.03). This association was unrelated to the age of the subjects or controls, or to ε4 alleles of the ApoE gene. The odds ratio for the effect of the homozygous low activity genotype was 1.7 (95% CI 1.08-2.67), with a population attributable risk of 33% (95% CI 5-54%). These findings indicate that the low activity allele of the serotonin transporter is a risk factor for late onset AD.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.comen_US
dc.relation.ispartofNeuroReporten_US
dc.subject.meshAge Of Onseten_US
dc.subject.meshAgeden_US
dc.subject.meshAlzheimer Disease - Epidemiology - Genetics - Physiopathologyen_US
dc.subject.meshCarrier Proteins - Biosynthesis - Geneticsen_US
dc.subject.meshDna Primersen_US
dc.subject.meshDna Transposable Elementsen_US
dc.subject.meshDisease Susceptibilityen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenetic Variationen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshLymphocytesen_US
dc.subject.meshMembrane Glycoproteins - Biosynthesis - Geneticsen_US
dc.subject.meshMembrane Transport Proteinsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNerve Tissue Proteinsen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshPromoter Regions, Geneticen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSequence Deletionen_US
dc.subject.meshSerotonin Plasma Membrane Transport Proteinsen_US
dc.titleAllelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimer's diseaseen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00001756-199702100-00021-
dc.identifier.pmid9106747-
dc.identifier.scopuseid_2-s2.0-14444278967en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-14444278967&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume8en_US
dc.identifier.issue3en_US
dc.identifier.spage683en_US
dc.identifier.epage686en_US
dc.identifier.isiWOS:A1997WQ00600023-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLi, T=36072008200en_US
dc.identifier.scopusauthoridHolmes, C=7202410686en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridVallada, H=7003742958en_US
dc.identifier.scopusauthoridBirkett, J=7004014779en_US
dc.identifier.scopusauthoridKirov, G=26643478800en_US
dc.identifier.scopusauthoridLesch, KP=19735689200en_US
dc.identifier.scopusauthoridPowell, J=7403541196en_US
dc.identifier.scopusauthoridLovestone, S=7005575001en_US
dc.identifier.scopusauthoridCollier, D=26642980600en_US

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