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Article: Pre-morbid characteristics and co-morbidity of methamphetamine users with and without psychosis

TitlePre-morbid characteristics and co-morbidity of methamphetamine users with and without psychosis
Authors
Issue Date2003
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
Citation
Psychological Medicine, 2003, v. 33 n. 8, p. 1407-1414 How to Cite?
AbstractBackground. The long-term use of methamphetamine (MAMP) can result in psychosis but it is not clear why some individuals develop psychotic symptoms, while others use MAMP regularly over long periods and remain unscathed. We set out to characterize MAMP users and to examine the relationship of pre-morbid personality, pre-morbid social function and other psychiatric disorders to MAMP psychosis. Method. Four hundred and forty-five amphetamine users were recruited from a psychiatric hospital and a detention centre in Taipei, and were assessed with the Diagnostic Interview for Genetic Studies (DIGS). Their parents were interviewed with the Premorbid Schizoid and Schizotypal Traits (PSST) and the Premorbid Social Adjustment (PSA) schedules. Pre-morbid characteristics and psychiatric co-morbidity were compared between the MAMP users with a lifetime diagnosis of MAMP psychosis and those without. Results. The MAMP users with psychosis presented a clinical picture which mimicked the positive symptoms of schizophrenia: 85% had auditory hallucinations; 71% persecutory delusions; 63% delusions of reference. Compared with their non-psychotic counterparts, these MAMP users were younger at first MAMP use, used larger amounts of MAMP, had a significantly higher mean PSST score, and higher rates of major depressive disorder, alcohol dependence and antisocial personality disorder. Conclusions. Earlier and larger use of MAMP was associated with increased risk of psychosis. Our data are also compatible with the view that pre-morbid schizoid/schizotypal personality predisposes MAMP users to develop psychosis, and that the greater the personality vulnerability, the longer the psychosis will persist.
Persistent Identifierhttp://hdl.handle.net/10722/175899
ISSN
2015 Impact Factor: 5.491
2015 SCImago Journal Rankings: 2.843
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, CKen_US
dc.contributor.authorLin, SKen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorBall, Den_US
dc.contributor.authorLoh, EWen_US
dc.contributor.authorHsiao, CCen_US
dc.contributor.authorChiang, YLen_US
dc.contributor.authorRee, SCen_US
dc.contributor.authorLee, CHen_US
dc.contributor.authorMurray, RMen_US
dc.date.accessioned2012-11-26T09:02:17Z-
dc.date.available2012-11-26T09:02:17Z-
dc.date.issued2003en_US
dc.identifier.citationPsychological Medicine, 2003, v. 33 n. 8, p. 1407-1414en_US
dc.identifier.issn0033-2917en_US
dc.identifier.urihttp://hdl.handle.net/10722/175899-
dc.description.abstractBackground. The long-term use of methamphetamine (MAMP) can result in psychosis but it is not clear why some individuals develop psychotic symptoms, while others use MAMP regularly over long periods and remain unscathed. We set out to characterize MAMP users and to examine the relationship of pre-morbid personality, pre-morbid social function and other psychiatric disorders to MAMP psychosis. Method. Four hundred and forty-five amphetamine users were recruited from a psychiatric hospital and a detention centre in Taipei, and were assessed with the Diagnostic Interview for Genetic Studies (DIGS). Their parents were interviewed with the Premorbid Schizoid and Schizotypal Traits (PSST) and the Premorbid Social Adjustment (PSA) schedules. Pre-morbid characteristics and psychiatric co-morbidity were compared between the MAMP users with a lifetime diagnosis of MAMP psychosis and those without. Results. The MAMP users with psychosis presented a clinical picture which mimicked the positive symptoms of schizophrenia: 85% had auditory hallucinations; 71% persecutory delusions; 63% delusions of reference. Compared with their non-psychotic counterparts, these MAMP users were younger at first MAMP use, used larger amounts of MAMP, had a significantly higher mean PSST score, and higher rates of major depressive disorder, alcohol dependence and antisocial personality disorder. Conclusions. Earlier and larger use of MAMP was associated with increased risk of psychosis. Our data are also compatible with the view that pre-morbid schizoid/schizotypal personality predisposes MAMP users to develop psychosis, and that the greater the personality vulnerability, the longer the psychosis will persist.en_US
dc.languageengen_US
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSMen_US
dc.relation.ispartofPsychological Medicineen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAlcoholism - Diagnosis - Epidemiology - Psychologyen_US
dc.subject.meshAmphetamine-Related Disorders - Diagnosis - Epidemiology - Psychologyen_US
dc.subject.meshAntisocial Personality Disorder - Diagnosis - Epidemiology - Psychologyen_US
dc.subject.meshCausalityen_US
dc.subject.meshCentral Nervous System Stimulants - Toxicityen_US
dc.subject.meshComorbidityen_US
dc.subject.meshDepressive Disorder, Major - Diagnosis - Epidemiology - Psychologyen_US
dc.subject.meshDisease Susceptibility - Psychologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHospitals, Psychiatricen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMethamphetamine - Toxicityen_US
dc.subject.meshPersonality Assessmenten_US
dc.subject.meshPrisonsen_US
dc.subject.meshPsychiatric Status Rating Scalesen_US
dc.subject.meshPsychoses, Substance-Induced - Diagnosis - Epidemiology - Psychologyen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSchizoid Personality Disorder - Diagnosis - Epidemiology - Psychologyen_US
dc.subject.meshSchizophrenia - Chemically Induced - Diagnosis - Epidemiologyen_US
dc.subject.meshSchizophrenic Psychologyen_US
dc.subject.meshSocial Adjustmenten_US
dc.subject.meshTaiwanen_US
dc.titlePre-morbid characteristics and co-morbidity of methamphetamine users with and without psychosisen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1017/S0033291703008353en_US
dc.identifier.pmid14672249-
dc.identifier.scopuseid_2-s2.0-10744223778en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-10744223778&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume33en_US
dc.identifier.issue8en_US
dc.identifier.spage1407en_US
dc.identifier.epage1414en_US
dc.identifier.isiWOS:000186981000008-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChen, CK=7501961684en_US
dc.identifier.scopusauthoridLin, SK=7407607751en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridBall, D=7202703810en_US
dc.identifier.scopusauthoridLoh, EW=7102994165en_US
dc.identifier.scopusauthoridHsiao, CC=14019592300en_US
dc.identifier.scopusauthoridChiang, YL=7201593437en_US
dc.identifier.scopusauthoridRee, SC=6603687834en_US
dc.identifier.scopusauthoridLee, CH=8083932800en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US

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