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Article: The heritability of bipolar affective disorder and the genetic relationship to unipolar depression

TitleThe heritability of bipolar affective disorder and the genetic relationship to unipolar depression
Authors
Issue Date2003
PublisherAmerican Medical Association. The Journal's web site is located at http://www.archgenpsychiatry.com
Citation
Archives Of General Psychiatry, 2003, v. 60 n. 5, p. 497-502 How to Cite?
AbstractBackground: Twin studies of bipolar affective disorder (BPD) have either been small or have not used explicit diagnostic criteria. There has been little use of genetic model fitting and no analyses to explore the etiological overlap with unipolar depression (UPD). Methods: Sixty-seven twin pairs, 30 monozygotic and 37 dizygotic, in which the proband had BPD were ascertained, and lifetime diagnoses were made using DSM-IV criteria. Univariate models were applied to estimate the contribution of additive genetic and environmental effects. Bipolar data were then combined with those from 68 monozygotic and 109 dizygotic pairs in which the proband had UPD. Two models were explored: a classic 2-threshold approach, in which BPD and UPD occupy the same continuum of liability but differ in severity, and a correlated liability model of mania and depression. Results: Heritability of BPD was estimated at 85% (95% confidence interval [CI], 0.73-0.93) using narrow concordance and 89% (95% CI, 0.61-1.0) using broad concordance, with no shared environmental effects detected. A 2-threshold model was an unsatisfactory fit. Fitting a correlated liability model revealed a genetic correlation of 0.65 (95% CI, 0.58-0.75) between mania and depression and a correlation of 0.59 (95% CI, 0.150.84) for nonfamilial environment. Approximately 71% of the genetic variance for mania was not shared with depression. Conclusions: As defined by the DSM-IV, BPD is highly heritable. There are substantial genetic and nonshared environmental correlations between mania and depression, but most of the genetic variance in liability to mania is specific to the manic syndrome.
Persistent Identifierhttp://hdl.handle.net/10722/175886
ISSN
2014 Impact Factor: 14.48
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMcguffin, Pen_US
dc.contributor.authorRijsdijk, Fen_US
dc.contributor.authorAndrew, Men_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorKatz, Ren_US
dc.contributor.authorCardno, Aen_US
dc.date.accessioned2012-11-26T09:02:10Z-
dc.date.available2012-11-26T09:02:10Z-
dc.date.issued2003en_US
dc.identifier.citationArchives Of General Psychiatry, 2003, v. 60 n. 5, p. 497-502en_US
dc.identifier.issn0003-990Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/175886-
dc.description.abstractBackground: Twin studies of bipolar affective disorder (BPD) have either been small or have not used explicit diagnostic criteria. There has been little use of genetic model fitting and no analyses to explore the etiological overlap with unipolar depression (UPD). Methods: Sixty-seven twin pairs, 30 monozygotic and 37 dizygotic, in which the proband had BPD were ascertained, and lifetime diagnoses were made using DSM-IV criteria. Univariate models were applied to estimate the contribution of additive genetic and environmental effects. Bipolar data were then combined with those from 68 monozygotic and 109 dizygotic pairs in which the proband had UPD. Two models were explored: a classic 2-threshold approach, in which BPD and UPD occupy the same continuum of liability but differ in severity, and a correlated liability model of mania and depression. Results: Heritability of BPD was estimated at 85% (95% confidence interval [CI], 0.73-0.93) using narrow concordance and 89% (95% CI, 0.61-1.0) using broad concordance, with no shared environmental effects detected. A 2-threshold model was an unsatisfactory fit. Fitting a correlated liability model revealed a genetic correlation of 0.65 (95% CI, 0.58-0.75) between mania and depression and a correlation of 0.59 (95% CI, 0.150.84) for nonfamilial environment. Approximately 71% of the genetic variance for mania was not shared with depression. Conclusions: As defined by the DSM-IV, BPD is highly heritable. There are substantial genetic and nonshared environmental correlations between mania and depression, but most of the genetic variance in liability to mania is specific to the manic syndrome.en_US
dc.languageengen_US
dc.publisherAmerican Medical Association. The Journal's web site is located at http://www.archgenpsychiatry.comen_US
dc.relation.ispartofArchives of General Psychiatryen_US
dc.subject.meshBipolar Disorder - Diagnosis - Geneticsen_US
dc.subject.meshConfidence Intervalsen_US
dc.subject.meshDepressive Disorder - Diagnosis - Geneticsen_US
dc.subject.meshDiseases In Twins - Geneticsen_US
dc.subject.meshFamilyen_US
dc.subject.meshGenetic Predisposition To Disease - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshLondonen_US
dc.subject.meshModels, Geneticen_US
dc.subject.meshRegistriesen_US
dc.subject.meshSeverity Of Illness Indexen_US
dc.subject.meshSocial Environmenten_US
dc.subject.meshTwins, Dizygotic - Geneticsen_US
dc.subject.meshTwins, Monozygotic - Geneticsen_US
dc.titleThe heritability of bipolar affective disorder and the genetic relationship to unipolar depressionen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1001/archpsyc.60.5.497en_US
dc.identifier.pmid12742871-
dc.identifier.scopuseid_2-s2.0-0037629099en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037629099&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume60en_US
dc.identifier.issue5en_US
dc.identifier.spage497en_US
dc.identifier.epage502en_US
dc.identifier.isiWOS:000182735000008-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMcGuffin, P=22954119700en_US
dc.identifier.scopusauthoridRijsdijk, F=6701830835en_US
dc.identifier.scopusauthoridAndrew, M=7102467006en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridKatz, R=7401788493en_US
dc.identifier.scopusauthoridCardno, A=7004499892en_US
dc.identifier.citeulike3805561-

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