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Article: Allelic association analysis of the dopamine D2, D3, 5-HT2A, and GABAAγ2 receptors and serotonin transporter genes with heroin abuse in Chinese subjects

TitleAllelic association analysis of the dopamine D2, D3, 5-HT2A, and GABAAγ2 receptors and serotonin transporter genes with heroin abuse in Chinese subjects
Authors
Issue Date2002
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 2002, v. 114 n. 3, p. 329-335 How to Cite?
AbstractFive candidate genes, the receptors DRD2, DRD3, HTR2A and GABAAγ/2, and the serotonin transporter (5-HTT) were analyzed for association with heroin abuse. We examined three polymorphisms (promoter - 141ΔC, Ser311Cys, and TaqI) in the DRD2 gene, one polymorphism (Ser9Gly) in the DRD3 gene, two polymorphisms (promoter - 1438G/A and T102C) in the HTR2A gene, two polymorphisms (VNTR and Del/Ins) in 5-HTT gene, and one polymorphism (G3145A) in GABAAγ2 gene in 121 Chinese heroin addicts and 194 controls. None of the polymorphisms differed significantly for allele, genotype, or haplotype frequencies, except for the DRD2 promoter polymorphism - 141ΔC (genotype-wise and allele-wise, P = 0.05, uncorrected). An additional 344 subjects with heroin abuse and 104 controls were investigated for the - 141ΔC polymorphism. In the second sample, there were no significant difference of genotype or allele frequencies between subjects with heroin abuse and normal controls. When we divided the sample by route of administration into nasal inhalers and IM or IV injectors, however, it produced a significant difference between inhalers of heroin and controls (genotype-wise, P = 0.006, allele-wise, P = 0.016) but not for injectors of heroin (genotype-wise, P = 0.81, allele-wise, P = 0.69). We also found that LD between all polymorphisms we examined in the gene was weak, possibly explaining why we see association of this polymorphism with heroin abuse but not with other markers in the gene. Overall our results indicates that the HTR2A, 5-HTT, DRD3 and GABAAγ2 genes are not likely to be a major genetic risk factor for heroin abuse in this population, with the exception of possible association between nasal inhalation and DRD2 promoter - 141ΔC polymorphism. © 2002 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/175875
ISSN
2003 Impact Factor: -999.999
2009 SCImago Journal Rankings: 1.100
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Ten_US
dc.contributor.authorLiu, Xen_US
dc.contributor.authorZhao, Jen_US
dc.contributor.authorHu, Xen_US
dc.contributor.authorBall, DMen_US
dc.contributor.authorLoh, EWen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorCollier, DAen_US
dc.date.accessioned2012-11-26T09:01:58Z-
dc.date.available2012-11-26T09:01:58Z-
dc.date.issued2002en_US
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 2002, v. 114 n. 3, p. 329-335en_US
dc.identifier.issn0148-7299en_US
dc.identifier.urihttp://hdl.handle.net/10722/175875-
dc.description.abstractFive candidate genes, the receptors DRD2, DRD3, HTR2A and GABAAγ/2, and the serotonin transporter (5-HTT) were analyzed for association with heroin abuse. We examined three polymorphisms (promoter - 141ΔC, Ser311Cys, and TaqI) in the DRD2 gene, one polymorphism (Ser9Gly) in the DRD3 gene, two polymorphisms (promoter - 1438G/A and T102C) in the HTR2A gene, two polymorphisms (VNTR and Del/Ins) in 5-HTT gene, and one polymorphism (G3145A) in GABAAγ2 gene in 121 Chinese heroin addicts and 194 controls. None of the polymorphisms differed significantly for allele, genotype, or haplotype frequencies, except for the DRD2 promoter polymorphism - 141ΔC (genotype-wise and allele-wise, P = 0.05, uncorrected). An additional 344 subjects with heroin abuse and 104 controls were investigated for the - 141ΔC polymorphism. In the second sample, there were no significant difference of genotype or allele frequencies between subjects with heroin abuse and normal controls. When we divided the sample by route of administration into nasal inhalers and IM or IV injectors, however, it produced a significant difference between inhalers of heroin and controls (genotype-wise, P = 0.006, allele-wise, P = 0.016) but not for injectors of heroin (genotype-wise, P = 0.81, allele-wise, P = 0.69). We also found that LD between all polymorphisms we examined in the gene was weak, possibly explaining why we see association of this polymorphism with heroin abuse but not with other markers in the gene. Overall our results indicates that the HTR2A, 5-HTT, DRD3 and GABAAγ2 genes are not likely to be a major genetic risk factor for heroin abuse in this population, with the exception of possible association between nasal inhalation and DRD2 promoter - 141ΔC polymorphism. © 2002 Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAllelesen_US
dc.subject.meshCarrier Proteins - Geneticsen_US
dc.subject.meshChinaen_US
dc.subject.meshDna - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHeroin Dependence - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMembrane Glycoproteins - Geneticsen_US
dc.subject.meshMembrane Transport Proteinsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMinisatellite Repeats - Geneticsen_US
dc.subject.meshNerve Tissue Proteinsen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshPromoter Regions, Genetic - Geneticsen_US
dc.subject.meshReceptor, Serotonin, 5-Ht2aen_US
dc.subject.meshReceptors, Cell Surface - Geneticsen_US
dc.subject.meshReceptors, Dopamine D2 - Geneticsen_US
dc.subject.meshReceptors, Dopamine D3en_US
dc.subject.meshReceptors, Gaba-A - Geneticsen_US
dc.subject.meshReceptors, Serotonin - Geneticsen_US
dc.subject.meshSerotonin Plasma Membrane Transport Proteinsen_US
dc.titleAllelic association analysis of the dopamine D2, D3, 5-HT2A, and GABAAγ2 receptors and serotonin transporter genes with heroin abuse in Chinese subjectsen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ajmg.10200en_US
dc.identifier.pmid11920858-
dc.identifier.scopuseid_2-s2.0-0037041339en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037041339&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume114en_US
dc.identifier.issue3en_US
dc.identifier.spage329en_US
dc.identifier.epage335en_US
dc.identifier.isiWOS:000174596600014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLi, T=36072008200en_US
dc.identifier.scopusauthoridLiu, X=7409286408en_US
dc.identifier.scopusauthoridZhao, J=7410311266en_US
dc.identifier.scopusauthoridHu, X=7404709241en_US
dc.identifier.scopusauthoridBall, DM=7202703810en_US
dc.identifier.scopusauthoridLoh, EW=7102994165en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridCollier, DA=26642980600en_US

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