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Article: Heritability of Schneider's first-rank symptoms

TitleHeritability of Schneider's first-rank symptoms
Authors
Issue Date2002
PublisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/
Citation
British Journal Of Psychiatry, 2002, v. 180 JAN., p. 35-38 How to Cite?
AbstractBackground: Schneider's first-rank symptoms are given particular weight when making a diagnosis of schizophrenia, but the nuclear syndrome, characterised by one or more first-rank symptoms, has been found previously to have no heritability. Aims: To estimate the heritability of the nuclear syndrome. Method: A total of 224 twin pairs (106 monozygotic, 118 same-gender dizygotic) were ascertained from the Maudsley Twin Register in London via probands with any psychosis. Lifetime-ever first-rank symptoms were rated using the OPCRIT checklist. Probandwise concordance rates were calculated for the nuclear syndrome and a heritability estimate was derived from biometric model fitting. Results: Probandwise concordance rates were 13/49 (26.5%) for monozygotic and 0/45 to 2/46 (0.0-4.3%) for dizygotic pairs. The heritability estimate for the best-fitting model was 71% (95% Cl 57-82). Conclusions: These results indicate that the nuclear syndrome shows substantial heritability, although this is slightly lower than that for schizophrenia as defined by the DSM and ICD systems.
Persistent Identifierhttp://hdl.handle.net/10722/175858
ISSN
2015 Impact Factor: 7.06
2015 SCImago Journal Rankings: 2.674
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCardno, AGen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorFarmer, AEen_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorMcguffin, Pen_US
dc.date.accessioned2012-11-26T09:01:51Z-
dc.date.available2012-11-26T09:01:51Z-
dc.date.issued2002en_US
dc.identifier.citationBritish Journal Of Psychiatry, 2002, v. 180 JAN., p. 35-38en_US
dc.identifier.issn0007-1250en_US
dc.identifier.urihttp://hdl.handle.net/10722/175858-
dc.description.abstractBackground: Schneider's first-rank symptoms are given particular weight when making a diagnosis of schizophrenia, but the nuclear syndrome, characterised by one or more first-rank symptoms, has been found previously to have no heritability. Aims: To estimate the heritability of the nuclear syndrome. Method: A total of 224 twin pairs (106 monozygotic, 118 same-gender dizygotic) were ascertained from the Maudsley Twin Register in London via probands with any psychosis. Lifetime-ever first-rank symptoms were rated using the OPCRIT checklist. Probandwise concordance rates were calculated for the nuclear syndrome and a heritability estimate was derived from biometric model fitting. Results: Probandwise concordance rates were 13/49 (26.5%) for monozygotic and 0/45 to 2/46 (0.0-4.3%) for dizygotic pairs. The heritability estimate for the best-fitting model was 71% (95% Cl 57-82). Conclusions: These results indicate that the nuclear syndrome shows substantial heritability, although this is slightly lower than that for schizophrenia as defined by the DSM and ICD systems.en_US
dc.languageengen_US
dc.publisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/en_US
dc.relation.ispartofBritish Journal of Psychiatryen_US
dc.subject.meshAdulten_US
dc.subject.meshBiometryen_US
dc.subject.meshDiseases In Twins - Diagnosis - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshModels, Statisticalen_US
dc.subject.meshPsychiatric Status Rating Scalesen_US
dc.subject.meshSchizophrenia - Diagnosis - Geneticsen_US
dc.subject.meshSyndromeen_US
dc.subject.meshTwins, Dizygoticen_US
dc.subject.meshTwins, Monozygoticen_US
dc.titleHeritability of Schneider's first-rank symptomsen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1192/bjp.180.1.35en_US
dc.identifier.pmid11772849-
dc.identifier.scopuseid_2-s2.0-0036155478en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036155478&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume180en_US
dc.identifier.issueJAN.en_US
dc.identifier.spage35en_US
dc.identifier.epage38en_US
dc.identifier.isiWOS:000173538500009-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridCardno, AG=7004499892en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridFarmer, AE=7102158824en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridMcGuffin, P=22954119700en_US

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