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Article: Susceptibility genes for a trait measure of attention deficit hyperactivity disorder: A pilot study in a non-clinical sample of twins

TitleSusceptibility genes for a trait measure of attention deficit hyperactivity disorder: A pilot study in a non-clinical sample of twins
Authors
Issue Date2001
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychres
Citation
Psychiatry Research, 2001, v. 105 n. 3, p. 273-278 How to Cite?
AbstractAttention deficit hyperactivity disorder (ADHD) is a highly heritable disorder, and molecular genetic studies are underway, with most researchers focusing on identifying susceptibility genes in clinical samples with ADHD. An alternative approach is to search for quantitative trait loci underlying the trait measure of ADHD in non-clinical samples. Positive findings of association of the dopamine transporter DAT1 480 bp allele (allele 10) and the DRD4 7 repeat allele with clinical ADHD have been previously reported. In this pilot study, we examined these polymorphisms in a selected population-based sample of twins (50 high scoring pairs, 42 low scoring pairs). There was a trend for an increase in the frequency of the dopamine receptor DRD4 7 repeat allele in the high-scoring concordant monozygotic twins (odds ratio = 1.4). Although this result was not statistically significant, the frequency of the 7 repeat allele was similar to that reported for our clinic sample of ADHD patients drawn from the same geographical area. There was a non-significant trend for an increased frequency of the DAT1 allele 10 (odds ratio = 1.3). These results suggest that a molecular genetic study based on a questionnaire-derived measure of ADHD in a non-clinical sample is feasible and the results appear to be comparable with those from studies of clinical cases. However, sample size and power are key issues to consider when using this approach. © 2001 Elsevier Science Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/175853
ISSN
2015 Impact Factor: 2.466
2015 SCImago Journal Rankings: 1.235
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPayton, Aen_US
dc.contributor.authorHolmes, Jen_US
dc.contributor.authorBarrett, JHen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorHarrington, Ren_US
dc.contributor.authorMcguffin, Pen_US
dc.contributor.authorOwen, Men_US
dc.contributor.authorOllier, Wen_US
dc.contributor.authorWorthington, Jen_US
dc.contributor.authorThapar, Aen_US
dc.date.accessioned2012-11-26T09:01:49Z-
dc.date.available2012-11-26T09:01:49Z-
dc.date.issued2001en_US
dc.identifier.citationPsychiatry Research, 2001, v. 105 n. 3, p. 273-278en_US
dc.identifier.issn0165-1781en_US
dc.identifier.urihttp://hdl.handle.net/10722/175853-
dc.description.abstractAttention deficit hyperactivity disorder (ADHD) is a highly heritable disorder, and molecular genetic studies are underway, with most researchers focusing on identifying susceptibility genes in clinical samples with ADHD. An alternative approach is to search for quantitative trait loci underlying the trait measure of ADHD in non-clinical samples. Positive findings of association of the dopamine transporter DAT1 480 bp allele (allele 10) and the DRD4 7 repeat allele with clinical ADHD have been previously reported. In this pilot study, we examined these polymorphisms in a selected population-based sample of twins (50 high scoring pairs, 42 low scoring pairs). There was a trend for an increase in the frequency of the dopamine receptor DRD4 7 repeat allele in the high-scoring concordant monozygotic twins (odds ratio = 1.4). Although this result was not statistically significant, the frequency of the 7 repeat allele was similar to that reported for our clinic sample of ADHD patients drawn from the same geographical area. There was a non-significant trend for an increased frequency of the DAT1 allele 10 (odds ratio = 1.3). These results suggest that a molecular genetic study based on a questionnaire-derived measure of ADHD in a non-clinical sample is feasible and the results appear to be comparable with those from studies of clinical cases. However, sample size and power are key issues to consider when using this approach. © 2001 Elsevier Science Ireland Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychresen_US
dc.relation.ispartofPsychiatry Researchen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAttention Deficit Disorder With Hyperactivity - Epidemiology - Genetics - Psychologyen_US
dc.subject.meshCarrier Proteins - Geneticsen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDna-Binding Proteins - Geneticsen_US
dc.subject.meshDopamine Plasma Membrane Transport Proteinsen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshHumansen_US
dc.subject.meshMembrane Glycoproteinsen_US
dc.subject.meshMembrane Transport Proteinsen_US
dc.subject.meshNerve Tissue Proteinsen_US
dc.subject.meshPilot Projectsen_US
dc.subject.meshQuestionnairesen_US
dc.subject.meshReceptors, Dopamine D2 - Geneticsen_US
dc.subject.meshReceptors, Dopamine D4en_US
dc.subject.meshSaccharomyces Cerevisiae Proteinsen_US
dc.subject.meshTwins, Monozygotic - Genetics - Psychologyen_US
dc.titleSusceptibility genes for a trait measure of attention deficit hyperactivity disorder: A pilot study in a non-clinical sample of twinsen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-1781(01)00342-0en_US
dc.identifier.pmid11814546-
dc.identifier.scopuseid_2-s2.0-0035981174en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035981174&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume105en_US
dc.identifier.issue3en_US
dc.identifier.spage273en_US
dc.identifier.epage278en_US
dc.identifier.isiWOS:000173825700012-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridPayton, A=6701719161en_US
dc.identifier.scopusauthoridHolmes, J=7403240141en_US
dc.identifier.scopusauthoridBarrett, JH=7403498817en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridHarrington, R=7201653417en_US
dc.identifier.scopusauthoridMcGuffin, P=22954119700en_US
dc.identifier.scopusauthoridOwen, M=36044041500en_US
dc.identifier.scopusauthoridOllier, W=7103047807en_US
dc.identifier.scopusauthoridWorthington, J=26322894900en_US
dc.identifier.scopusauthoridThapar, A=34572905300en_US

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