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Article: Number of older siblings of individuals diagnosed with schizophrenia

TitleNumber of older siblings of individuals diagnosed with schizophrenia
Authors
Issue Date2001
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2001, v. 47 n. 2-3, p. 275-280 How to Cite?
AbstractOne of the most consistent epidemiological findings in schizophrenia research is the small excess of late winter/early spring births. There is also evidence that schizophrenia is associated with urban birth and with later birth order. One interpretation of these three findings is that respiratory viral infections brought into the household by children in crowded areas could disrupt foetal brain development and predispose to schizophrenia in later life. To further explore this hypothesis, case register data were used to assess if schizophrenics with a greater number of older siblings are more likely to be born in urban areas and during late winter/early spring months. Data from the Dublin and Three County Case Register were compiled relating to 2969 patients with schizophrenia and 5904 patients with neurosis. We used logistic regression analysis to determine if the number of older siblings differentiated schizophrenia from neurosis after controlling for the effects of gender, urban/rural birth, season of birth and sibship size, and to examine whether any interactions existed. The number of older siblings did not predict a diagnosis of schizophrenia over neurosis. There was no interaction between number of older siblings and urban birth, between number of older siblings and spring birth, or between number of older siblings, season of birth and urban birth. These data do not support the hypothesis that schizophrenia, by comparison with neurosis, is associated with an increased number of older siblings or that there is an interaction between number of older siblings, urban birth or season of birth. © 2001 Elsevier Science B.V.
Persistent Identifierhttp://hdl.handle.net/10722/175847
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMcdonald, Cen_US
dc.contributor.authorO'callaghan, Een_US
dc.contributor.authorKeogh, Fen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorKinsella, Aen_US
dc.contributor.authorMorris, Men_US
dc.contributor.authorWalsh, Den_US
dc.date.accessioned2012-11-26T09:01:46Z-
dc.date.available2012-11-26T09:01:46Z-
dc.date.issued2001en_US
dc.identifier.citationSchizophrenia Research, 2001, v. 47 n. 2-3, p. 275-280en_US
dc.identifier.issn0920-9964en_US
dc.identifier.urihttp://hdl.handle.net/10722/175847-
dc.description.abstractOne of the most consistent epidemiological findings in schizophrenia research is the small excess of late winter/early spring births. There is also evidence that schizophrenia is associated with urban birth and with later birth order. One interpretation of these three findings is that respiratory viral infections brought into the household by children in crowded areas could disrupt foetal brain development and predispose to schizophrenia in later life. To further explore this hypothesis, case register data were used to assess if schizophrenics with a greater number of older siblings are more likely to be born in urban areas and during late winter/early spring months. Data from the Dublin and Three County Case Register were compiled relating to 2969 patients with schizophrenia and 5904 patients with neurosis. We used logistic regression analysis to determine if the number of older siblings differentiated schizophrenia from neurosis after controlling for the effects of gender, urban/rural birth, season of birth and sibship size, and to examine whether any interactions existed. The number of older siblings did not predict a diagnosis of schizophrenia over neurosis. There was no interaction between number of older siblings and urban birth, between number of older siblings and spring birth, or between number of older siblings, season of birth and urban birth. These data do not support the hypothesis that schizophrenia, by comparison with neurosis, is associated with an increased number of older siblings or that there is an interaction between number of older siblings, urban birth or season of birth. © 2001 Elsevier Science B.V.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_US
dc.relation.ispartofSchizophrenia Researchen_US
dc.subject.meshBirth Orderen_US
dc.subject.meshCatchment Area (Health)en_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshIreland - Epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNeurotic Disorders - Diagnosis - Epidemiologyen_US
dc.subject.meshRegistriesen_US
dc.subject.meshSchizophrenia - Diagnosis - Epidemiologyen_US
dc.subject.meshSeasonsen_US
dc.titleNumber of older siblings of individuals diagnosed with schizophreniaen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0920-9964(00)00134-1en_US
dc.identifier.pmid11278145-
dc.identifier.scopuseid_2-s2.0-0035281247en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035281247&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume47en_US
dc.identifier.issue2-3en_US
dc.identifier.spage275en_US
dc.identifier.epage280en_US
dc.identifier.isiWOS:000167537400019-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridMcDonald, C=8749594800en_US
dc.identifier.scopusauthoridO'Callaghan, E=7005694363en_US
dc.identifier.scopusauthoridKeogh, F=6603255180en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridKinsella, A=7005415614en_US
dc.identifier.scopusauthoridMorris, M=24344799600en_US
dc.identifier.scopusauthoridWalsh, D=7402053258en_US

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