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Article: Clinical and prognostic significance of human papillomavirus in a Chinese population of cervical cancers

TitleClinical and prognostic significance of human papillomavirus in a Chinese population of cervical cancers
Authors
Issue Date2001
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/GOI
Citation
Gynecologic And Obstetric Investigation, 2001, v. 51 n. 3, p. 202-207 How to Cite?
AbstractObjective: To investigate the clinical and prognostic significance of human papillomavirus (HPV) in a Chinese population of cervical cancers. Methods: We studied 121 cervical cancer tissue samples from patients treated at our hospital. Identification and typing of HPV were done by polymerase chain reaction (PCR) using consensus primers MY11 and MY09 followed by direct DNA sequencing. The results were correlated with various clinical and prognostic parameters. Results: We found HPV DNA in 95 (78.5%) cases, including HPV-16 in 59 (48.8%) and HPV-18 in 14 (11.6%) cases. χ 2 analysis revealed no significant correlation between the presence of HPV DNA and age at diagnosis, clinical stage, histologic type, tumor grading, 2-year and 5-year survival rate. Of the factors evaluated, age at diagnosis and histologic type were found to have a statistically significant relationship with HPV type. The mean age of the HPV-18 group was 48.6 years compared to 57.1 years for the HPV-16 group (p = 0.045) and 58.2 years for the HPV-negative group (p = 0.04). HPV-18 was detected more often in adenocarcinomas (AC) than in squamous cell carcinomas (SCC). Conversely HPV-16 was detected significantly more often in SCC (p < 0.0001). The HPV-negative group also had a higher incidence of SCC (p = 0.007). HPV-18-positive patients seemed to have more nodal involvement than both HPV-16-positive patients (45.5 vs. 20.8%) and HPV-negative patients (45.5 vs. 18.2%); however, it did not reach statistical significance. Conclusions: These observations suggest that the presence of HPV DNA does not bear any clinical or prognostic significance in a Chinese population of cervical cancers. HPV-18 is found more often in younger patients and is associated with AC. Copyright © 2001 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/175842
ISSN
2015 Impact Factor: 1.672
2015 SCImago Journal Rankings: 0.752
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLo, KWKen_US
dc.contributor.authorCheung, THen_US
dc.contributor.authorChung, TKHen_US
dc.contributor.authorWang, VWen_US
dc.contributor.authorPoon, JSen_US
dc.contributor.authorLi, JCBen_US
dc.contributor.authorLam, Pen_US
dc.contributor.authorWong, YFen_US
dc.date.accessioned2012-11-26T09:01:44Z-
dc.date.available2012-11-26T09:01:44Z-
dc.date.issued2001en_US
dc.identifier.citationGynecologic And Obstetric Investigation, 2001, v. 51 n. 3, p. 202-207en_US
dc.identifier.issn0378-7346en_US
dc.identifier.urihttp://hdl.handle.net/10722/175842-
dc.description.abstractObjective: To investigate the clinical and prognostic significance of human papillomavirus (HPV) in a Chinese population of cervical cancers. Methods: We studied 121 cervical cancer tissue samples from patients treated at our hospital. Identification and typing of HPV were done by polymerase chain reaction (PCR) using consensus primers MY11 and MY09 followed by direct DNA sequencing. The results were correlated with various clinical and prognostic parameters. Results: We found HPV DNA in 95 (78.5%) cases, including HPV-16 in 59 (48.8%) and HPV-18 in 14 (11.6%) cases. χ 2 analysis revealed no significant correlation between the presence of HPV DNA and age at diagnosis, clinical stage, histologic type, tumor grading, 2-year and 5-year survival rate. Of the factors evaluated, age at diagnosis and histologic type were found to have a statistically significant relationship with HPV type. The mean age of the HPV-18 group was 48.6 years compared to 57.1 years for the HPV-16 group (p = 0.045) and 58.2 years for the HPV-negative group (p = 0.04). HPV-18 was detected more often in adenocarcinomas (AC) than in squamous cell carcinomas (SCC). Conversely HPV-16 was detected significantly more often in SCC (p < 0.0001). The HPV-negative group also had a higher incidence of SCC (p = 0.007). HPV-18-positive patients seemed to have more nodal involvement than both HPV-16-positive patients (45.5 vs. 20.8%) and HPV-negative patients (45.5 vs. 18.2%); however, it did not reach statistical significance. Conclusions: These observations suggest that the presence of HPV DNA does not bear any clinical or prognostic significance in a Chinese population of cervical cancers. HPV-18 is found more often in younger patients and is associated with AC. Copyright © 2001 S. Karger AG, Basel.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/GOIen_US
dc.relation.ispartofGynecologic and Obstetric Investigationen_US
dc.subject.meshAdenocarcinoma - Pathology - Virologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshCarcinoma, Squamous Cell - Pathology - Virologyen_US
dc.subject.meshDna, Viral - Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLymphatic Metastasisen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshPapillomaviridae - Classification - Genetics - Isolation & Purificationen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPrognosisen_US
dc.subject.meshUterine Cervical Neoplasms - Pathology - Virologyen_US
dc.titleClinical and prognostic significance of human papillomavirus in a Chinese population of cervical cancersen_US
dc.typeArticleen_US
dc.identifier.emailLi, JCB: jamesli@hku.hken_US
dc.identifier.authorityLi, JCB=rp00496en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000052925en_US
dc.identifier.pmid11306910-
dc.identifier.scopuseid_2-s2.0-0035045648en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035045648&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume51en_US
dc.identifier.issue3en_US
dc.identifier.spage202en_US
dc.identifier.epage207en_US
dc.identifier.isiWOS:000168252800013-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridLo, KWK=24302880900en_US
dc.identifier.scopusauthoridCheung, TH=7103334169en_US
dc.identifier.scopusauthoridChung, TKH=8866217800en_US
dc.identifier.scopusauthoridWang, VW=7007164250en_US
dc.identifier.scopusauthoridPoon, JS=7005903729en_US
dc.identifier.scopusauthoridLi, JCB=23103447500en_US
dc.identifier.scopusauthoridLam, P=55137392000en_US
dc.identifier.scopusauthoridWong, YF=7403041448en_US

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