File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Attention deficit hyperactivity disorder (ADHD) and the dopamine D4 receptor gene: Evidence of association but no linkage in a UK sample

TitleAttention deficit hyperactivity disorder (ADHD) and the dopamine D4 receptor gene: Evidence of association but no linkage in a UK sample
Authors
Issue Date2001
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/mp
Citation
Molecular Psychiatry, 2001, v. 6 n. 4, p. 440-444 How to Cite?
AbstractRecent studies report association and linkage between attention deficit hyperactivity disorder (ADHD) and the 7-repeat allele of a 48 base-pair repeat in the dopamine D4 receptor gene (DRD4). We examined the frequency of this allele in a sample of probands with DSM-IV ADHD using a case-control design, as well as the transmission disequilibrium test (TDT) and haplotype-based haplotype relative risk (HHRR) in the subset of probands with DNA available from both parents. One hundred and thirty-two ADHD probands were compared with 189 controls (x 2=6.17, 1 df, P=0.01, OR=1.73, 95% Cl=1.11-2.71). A total of 85 complete trios were available for within-family tests of association and linkage. Fifty-two heterozygous parents carrying one copy of the 7-repeat were informative for the TDT (29 transmitted vs 23 nontransmitted, x 2=0.69). Analysis of the entire sample of 132 probands using TRANSMIT provided no additional evidence for excess transmission of the 7-repeat allele (58 transmitted vs 54 non-transmitted). HHRR gave similar results. We conclude that the case-control findings are likely to be falsely positive, resulting from genetic stratification. However we can not rule out alternative explanations of low statistical power and gene-environment correlation.
Persistent Identifierhttp://hdl.handle.net/10722/175838
ISSN
2015 Impact Factor: 13.314
2015 SCImago Journal Rankings: 6.790
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMill, Jen_US
dc.contributor.authorCurran, Sen_US
dc.contributor.authorKent, Len_US
dc.contributor.authorRichards, Sen_US
dc.contributor.authorGould, Aen_US
dc.contributor.authorVirdee, Ven_US
dc.contributor.authorHuckett, Len_US
dc.contributor.authorSharp, Jen_US
dc.contributor.authorBatten, Cen_US
dc.contributor.authorFernando, Sen_US
dc.contributor.authorSimanoff, Een_US
dc.contributor.authorThompson, Men_US
dc.contributor.authorZhao, Jen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorTaylor, Een_US
dc.contributor.authorAsherson, Pen_US
dc.date.accessioned2012-11-26T09:01:42Z-
dc.date.available2012-11-26T09:01:42Z-
dc.date.issued2001en_US
dc.identifier.citationMolecular Psychiatry, 2001, v. 6 n. 4, p. 440-444en_US
dc.identifier.issn1359-4184en_US
dc.identifier.urihttp://hdl.handle.net/10722/175838-
dc.description.abstractRecent studies report association and linkage between attention deficit hyperactivity disorder (ADHD) and the 7-repeat allele of a 48 base-pair repeat in the dopamine D4 receptor gene (DRD4). We examined the frequency of this allele in a sample of probands with DSM-IV ADHD using a case-control design, as well as the transmission disequilibrium test (TDT) and haplotype-based haplotype relative risk (HHRR) in the subset of probands with DNA available from both parents. One hundred and thirty-two ADHD probands were compared with 189 controls (x 2=6.17, 1 df, P=0.01, OR=1.73, 95% Cl=1.11-2.71). A total of 85 complete trios were available for within-family tests of association and linkage. Fifty-two heterozygous parents carrying one copy of the 7-repeat were informative for the TDT (29 transmitted vs 23 nontransmitted, x 2=0.69). Analysis of the entire sample of 132 probands using TRANSMIT provided no additional evidence for excess transmission of the 7-repeat allele (58 transmitted vs 54 non-transmitted). HHRR gave similar results. We conclude that the case-control findings are likely to be falsely positive, resulting from genetic stratification. However we can not rule out alternative explanations of low statistical power and gene-environment correlation.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/mpen_US
dc.relation.ispartofMolecular Psychiatryen_US
dc.subject.meshAllelesen_US
dc.subject.meshAttention Deficit Disorder With Hyperactivity - Genetics - Psychologyen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChilden_US
dc.subject.meshEuropean Continental Ancestry Group - Geneticsen_US
dc.subject.meshExonsen_US
dc.subject.meshFalse Positive Reactionsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenotypeen_US
dc.subject.meshGreat Britainen_US
dc.subject.meshHaplotypesen_US
dc.subject.meshHumansen_US
dc.subject.meshLinkage Disequilibriumen_US
dc.subject.meshMaleen_US
dc.subject.meshMinisatellite Repeatsen_US
dc.subject.meshParentsen_US
dc.subject.meshReceptors, Dopamine D2 - Geneticsen_US
dc.subject.meshReceptors, Dopamine D4en_US
dc.subject.meshReproducibility Of Resultsen_US
dc.subject.meshRisken_US
dc.subject.meshSoftwareen_US
dc.titleAttention deficit hyperactivity disorder (ADHD) and the dopamine D4 receptor gene: Evidence of association but no linkage in a UK sampleen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/sj.mp.4000881en_US
dc.identifier.pmid11443530-
dc.identifier.scopuseid_2-s2.0-0034979209en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034979209&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume6en_US
dc.identifier.issue4en_US
dc.identifier.spage440en_US
dc.identifier.epage444en_US
dc.identifier.isiWOS:000169104900015-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridMill, J=7006450209en_US
dc.identifier.scopusauthoridCurran, S=7103220956en_US
dc.identifier.scopusauthoridKent, L=7006258806en_US
dc.identifier.scopusauthoridRichards, S=55251257500en_US
dc.identifier.scopusauthoridGould, A=14633315100en_US
dc.identifier.scopusauthoridVirdee, V=6504315534en_US
dc.identifier.scopusauthoridHuckett, L=6507676398en_US
dc.identifier.scopusauthoridSharp, J=7401915341en_US
dc.identifier.scopusauthoridBatten, C=14632929500en_US
dc.identifier.scopusauthoridFernando, S=27267693100en_US
dc.identifier.scopusauthoridSimanoff, E=6504089730en_US
dc.identifier.scopusauthoridThompson, M=14526195300en_US
dc.identifier.scopusauthoridZhao, J=7410311266en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridTaylor, E=7403206584en_US
dc.identifier.scopusauthoridAsherson, P=35402700900en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats