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Article: Twin study of symptom dimensions in psychoses

TitleTwin study of symptom dimensions in psychoses
Authors
Issue Date2001
PublisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/
Citation
British Journal Of Psychiatry, 2001, v. 178 JULY, p. 39-45 How to Cite?
AbstractBackground: Symptomatology in psychoses can be summarised as quantitative symptom dimensions, but their genetic basis is unknown. Aims: To investigate whether genes make an important contribution to symptom dimensions. Method; A total of 224 probandwise twin pairs (106 monozygotic, 118 same-gender dizygotic) where probands had psychosis were ascertained from the Maudsley Twin Register in London. Factor analysis was performed on lifetime symptoms rated on the Operational Checklist for Psychotic Disorders (OPCRIT). Correlations of dimension scores within monozygotic and dizygotic pairs concordant for Research Diagnostic Criteria psychoses were performed. Relationships between dimension scores and genetic loading for psychoses were assessed using logistic regression. Results: Patterns of familial aggregation consistent with a genetic effect were found for the disorganised dimension and for some measures of the negative, manic and general psychotic dimensions. Disorganised dimension scores were related significantly to genetic loading for psychoses. Conclusions: The disorganised dimension, and possibly other symptom dimensions, may be useful phenotypes for molecular genetic studies of psychoses.
Persistent Identifierhttp://hdl.handle.net/10722/175836
ISSN
2015 Impact Factor: 7.06
2015 SCImago Journal Rankings: 2.674
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCardno, AGen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorMcguffin, Pen_US
dc.date.accessioned2012-11-26T09:01:41Z-
dc.date.available2012-11-26T09:01:41Z-
dc.date.issued2001en_US
dc.identifier.citationBritish Journal Of Psychiatry, 2001, v. 178 JULY, p. 39-45en_US
dc.identifier.issn0007-1250en_US
dc.identifier.urihttp://hdl.handle.net/10722/175836-
dc.description.abstractBackground: Symptomatology in psychoses can be summarised as quantitative symptom dimensions, but their genetic basis is unknown. Aims: To investigate whether genes make an important contribution to symptom dimensions. Method; A total of 224 probandwise twin pairs (106 monozygotic, 118 same-gender dizygotic) where probands had psychosis were ascertained from the Maudsley Twin Register in London. Factor analysis was performed on lifetime symptoms rated on the Operational Checklist for Psychotic Disorders (OPCRIT). Correlations of dimension scores within monozygotic and dizygotic pairs concordant for Research Diagnostic Criteria psychoses were performed. Relationships between dimension scores and genetic loading for psychoses were assessed using logistic regression. Results: Patterns of familial aggregation consistent with a genetic effect were found for the disorganised dimension and for some measures of the negative, manic and general psychotic dimensions. Disorganised dimension scores were related significantly to genetic loading for psychoses. Conclusions: The disorganised dimension, and possibly other symptom dimensions, may be useful phenotypes for molecular genetic studies of psychoses.en_US
dc.languageengen_US
dc.publisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/en_US
dc.relation.ispartofBritish Journal of Psychiatryen_US
dc.subject.meshDiseases In Twins - Geneticsen_US
dc.subject.meshFactor Analysis, Statisticalen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLogistic Modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPedigreeen_US
dc.subject.meshPsychiatric Status Rating Scales - Statistics & Numerical Dataen_US
dc.subject.meshPsychotic Disorders - Geneticsen_US
dc.subject.meshSchizophrenia - Diagnosis - Geneticsen_US
dc.subject.meshTwins, Dizygoticen_US
dc.subject.meshTwins, Monozygoticen_US
dc.titleTwin study of symptom dimensions in psychosesen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1192/bjp.179.1.39-
dc.identifier.pmid11435267-
dc.identifier.scopuseid_2-s2.0-0034930902en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034930902&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume178en_US
dc.identifier.issueJULYen_US
dc.identifier.spage39en_US
dc.identifier.epage45en_US
dc.identifier.isiWOS:000169835800009-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridCardno, AG=7004499892en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridMcGuffin, P=22954119700en_US

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