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Article: Pharmacogenetic prediction of clozapine response

TitlePharmacogenetic prediction of clozapine response
Authors
Arranz, MJMunro, JBirkett, JBolonna, AMancama, DSodhi, MLesch, KPMeyer, JFWSham, PCollier, DAMurray, RMKerwin, RW
Issue Date2000
PublisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet
Citation
Lancet, 2000, v. 355 n. 9215, p. 1615-1616 How to Cite?
DOI: http://dx.doi.org/10.1016/S0140-6736(00)02221-2
AbstractWe did association studies in multiple candidate genes to find the combination of polymorphisms that give the best predictive value of response to clozapine in schizophrenic patients. A combination of six polymorphisms in neurotransmitter-receptor-related genes resulted in 76.7% success in the prediction of clozapine response (p = 0.0001) and a sensitivity of 95% (± 0.04) for satisfactory response. These results will form the basis for a simple test to enhance the usefulness of clozapine in psychiatric treatment.
Persistent Identifierhttp://hdl.handle.net/10722/175828
ISSN
0140-6736
2021 Impact Factor: 202.731
2020 SCImago Journal Rankings: 13.103
ISI Accession Number ID
WOS:000086981200016
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorArranz, MJen_US
dc.contributor.authorMunro, Jen_US
dc.contributor.authorBirkett, Jen_US
dc.contributor.authorBolonna, Aen_US
dc.contributor.authorMancama, Den_US
dc.contributor.authorSodhi, Men_US
dc.contributor.authorLesch, KPen_US
dc.contributor.authorMeyer, JFWen_US
dc.contributor.authorSham, Pen_US
dc.contributor.authorCollier, DAen_US
dc.contributor.authorMurray, RMen_US
dc.contributor.authorKerwin, RWen_US
dc.date.accessioned2012-11-26T09:01:38Z-
dc.date.available2012-11-26T09:01:38Z-
dc.date.issued2000en_US
dc.identifier.citationLancet, 2000, v. 355 n. 9215, p. 1615-1616en_US
dc.identifier.issn0140-6736en_US
dc.identifier.urihttp://hdl.handle.net/10722/175828-
dc.description.abstractWe did association studies in multiple candidate genes to find the combination of polymorphisms that give the best predictive value of response to clozapine in schizophrenic patients. A combination of six polymorphisms in neurotransmitter-receptor-related genes resulted in 76.7% success in the prediction of clozapine response (p = 0.0001) and a sensitivity of 95% (± 0.04) for satisfactory response. These results will form the basis for a simple test to enhance the usefulness of clozapine in psychiatric treatment.en_US
dc.languageengen_US
dc.publisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lanceten_US
dc.relation.ispartofLanceten_US
dc.subject.meshAllelesen_US
dc.subject.meshAntipsychotic Agents - Therapeutic Useen_US
dc.subject.meshClozapine - Therapeutic Useen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshPharmacogeneticsen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshReceptors, Serotonin - Geneticsen_US
dc.subject.meshSensitivity And Specificityen_US
dc.titlePharmacogenetic prediction of clozapine responseen_US
dc.typeArticleen_US
dc.identifier.emailSham, P: pcsham@hku.hken_US
dc.identifier.authoritySham, P=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0140-6736(00)02221-2-
dc.identifier.pmid10821369-
dc.identifier.scopuseid_2-s2.0-0034612110en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034612110&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume355en_US
dc.identifier.issue9215en_US
dc.identifier.spage1615en_US
dc.identifier.epage1616en_US
dc.identifier.isiWOS:000086981200016-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridArranz, MJ=7006010757en_US
dc.identifier.scopusauthoridMunro, J=7102726057en_US
dc.identifier.scopusauthoridBirkett, J=7004014779en_US
dc.identifier.scopusauthoridBolonna, A=8131196200en_US
dc.identifier.scopusauthoridMancama, D=6603648170en_US
dc.identifier.scopusauthoridSodhi, M=7004463507en_US
dc.identifier.scopusauthoridLesch, KP=19735689200en_US
dc.identifier.scopusauthoridMeyer, JFW=7406100185en_US
dc.identifier.scopusauthoridSham, P=34573429300en_US
dc.identifier.scopusauthoridCollier, DA=26642980600en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US
dc.identifier.scopusauthoridKerwin, RW=7102904567en_US
dc.identifier.issnl0140-6736-

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