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Article: Childhood schizotypy and positive symptoms in schizophrenic patients predict schizotypy in relatives

TitleChildhood schizotypy and positive symptoms in schizophrenic patients predict schizotypy in relatives
Authors
Issue Date2000
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2000, v. 44 n. 2, p. 129-136 How to Cite?
AbstractBackground: Schizotypy is one phenotypic expression of the familial-genetic liability to schizophrenia, but its precise relationship to frank psychotic symptoms remains unclear. We, therefore, set out to examine the relationships between (a) premorbid personality in schizophrenic patients, (b) the psychopathology they showed, and (c) schizotypal traits in their relatives. Method: Ninety consecutively admitted schizophrenic patients were interviewed with the Present State Examination (PSE). Their mothers were interviewed concerning their childhood personality and social adjustment, and 121 of their well relatives were evaluated with three different schizotypal scales. Factor analyses were carried out on (a) the nine main psychotic symptoms from the patients PSE interview, and on (b) the schizotypal features derived from the scales completed by the first-degree relatives. Correlation coefficients were calculated between premorbid personality traits, and factor scores in probands and in relatives. Results: No relationship was found between childhood schizoid-schizotypal personality traits and any particular dimension of psychopathology in patients. The positive syndrome in patients was correlated with higher scores for relatives on the three schizotypy scales, but did not predict any specific pattern of schizotypy in the relatives. Premorbid schizoid-schizotypal traits were also correlated with schizotypy in the relatives. Conclusions: Schizotypy in relatives has a familial relationship with schizoid-schizotypal traits in the childhood, and with positive symptoms during the illness, of schizophrenic patients. 2000 Elsevier Science B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/175827
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMata, Ien_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorGilvarry, CMen_US
dc.contributor.authorJones, PBen_US
dc.contributor.authorLewis, SWen_US
dc.contributor.authorMurray, RMen_US
dc.date.accessioned2012-11-26T09:01:37Z-
dc.date.available2012-11-26T09:01:37Z-
dc.date.issued2000en_US
dc.identifier.citationSchizophrenia Research, 2000, v. 44 n. 2, p. 129-136en_US
dc.identifier.issn0920-9964en_US
dc.identifier.urihttp://hdl.handle.net/10722/175827-
dc.description.abstractBackground: Schizotypy is one phenotypic expression of the familial-genetic liability to schizophrenia, but its precise relationship to frank psychotic symptoms remains unclear. We, therefore, set out to examine the relationships between (a) premorbid personality in schizophrenic patients, (b) the psychopathology they showed, and (c) schizotypal traits in their relatives. Method: Ninety consecutively admitted schizophrenic patients were interviewed with the Present State Examination (PSE). Their mothers were interviewed concerning their childhood personality and social adjustment, and 121 of their well relatives were evaluated with three different schizotypal scales. Factor analyses were carried out on (a) the nine main psychotic symptoms from the patients PSE interview, and on (b) the schizotypal features derived from the scales completed by the first-degree relatives. Correlation coefficients were calculated between premorbid personality traits, and factor scores in probands and in relatives. Results: No relationship was found between childhood schizoid-schizotypal personality traits and any particular dimension of psychopathology in patients. The positive syndrome in patients was correlated with higher scores for relatives on the three schizotypy scales, but did not predict any specific pattern of schizotypy in the relatives. Premorbid schizoid-schizotypal traits were also correlated with schizotypy in the relatives. Conclusions: Schizotypy in relatives has a familial relationship with schizoid-schizotypal traits in the childhood, and with positive symptoms during the illness, of schizophrenic patients. 2000 Elsevier Science B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_US
dc.relation.ispartofSchizophrenia Researchen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshQuestionnairesen_US
dc.subject.meshSchizophrenia - Diagnosis - Geneticsen_US
dc.subject.meshSchizotypal Personality Disorder - Diagnosis - Geneticsen_US
dc.subject.meshSeverity Of Illness Indexen_US
dc.subject.meshSex Factorsen_US
dc.subject.meshSocial Adjustmenten_US
dc.titleChildhood schizotypy and positive symptoms in schizophrenic patients predict schizotypy in relativesen_US
dc.typeArticleen_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0920-9964(99)00222-4en_US
dc.identifier.pmid10913744-
dc.identifier.scopuseid_2-s2.0-0034601621en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034601621&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume44en_US
dc.identifier.issue2en_US
dc.identifier.spage129en_US
dc.identifier.epage136en_US
dc.identifier.isiWOS:000088248300005-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridMata, I=9638989000en_US
dc.identifier.scopusauthoridSham, PC=34573429300en_US
dc.identifier.scopusauthoridGilvarry, CM=6701857173en_US
dc.identifier.scopusauthoridJones, PB=36078972900en_US
dc.identifier.scopusauthoridLewis, SW=7404041267en_US
dc.identifier.scopusauthoridMurray, RM=35406239400en_US

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